Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment

Houwing, Danielle J.; Heijkoop, Roy; Olivier, Jocelien; Snoeren, Eelke M.S.

doi:10.1016/j.neuropharm.2019.03.037

Cited by 21 publications

(47 citation statements)

References 62 publications

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“…Recently, we found that both male and female rats that were perinatally exposed to fluoxetine more often spent passive moments in the company of a conspecific (social resting) compared with control rats [31], confirming the risk for affected social behavior resulting from perinatal SSRI exposure.…”

Section: Introductionmentioning

confidence: 61%

“…This study describes the data from subsequent analyses of video recordings from another study. This means that the rats and thus the procedures were the same as mentioned in [31], but the behavioral observations were chosen and designed specifically for the purpose of the current study. The materials and methods describe the steps that were required for the current study.…”

Section: Methodsmentioning

confidence: 99%

“…These littermates had been housed in different home cages since weaning. Details of the litter distribution in the cohorts can be found in the supplemental materials of [31].…”

Section: Design Of the Studymentioning

confidence: 99%

“…We, therefore, observed the behavior of all rats during the 15 minutes after fights and expected to find an increase in active social behavior directed at conspecifics. In a previous study, we found that phenotypes in perinatally SSRI exposed offspring can alter after experiencing a stressful event [31]. We, therefore, also investigated whether the performance of prosocial behavior is changed after an additional stressor.…”

Section: Introductionmentioning

confidence: 97%

“…In terms of social interaction at adulthood, the findings are more controversial. Some studies have indicated that developmental SSRI exposure decreases social interaction in either male offspring [25,27] or female offspring [31], while others found an increase in sniffing behavior towards conspecifics [32,33]. When looking at the motivation for social interaction in particular, the majority found that SSRI exposure negatively affects the motivation to start social contact [26,28,29,34].…”

Section: Introductionmentioning

confidence: 99%

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Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure

Heinla

Heijkoop

Houwing

et al. 2019

Preprint

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AbstractSSRIs are commonly used to treat pregnant women with depression. However, SSRIs can cross the placenta and affect the development of the fetus. The effects of perinatal SSRI exposure, and especially the effects on social behavior, are still incompletely documented. This study first aims to investigate whether rats show prosocial behavior in the form of consolation behavior. Secondly, it aims to investigate whether perinatal SSRI exposure affects this prosocial behavior. At last, we investigate whether the behavior changed after the rats had been exposed to an additional white-noise stressor.Rat dams received 10 mg/kg/d fluoxetine (FLX) or vehicle (CTR) via oral gavage from gestational day 1 until postnatal day 21. At adulthood, the rat offspring were housed in four cohorts of 4 females and 4 males in a seminatural environment. As prosocial behaviors are more prominent after stressful situations, we investigated the behavioral response of rats immediately after natural aggressive encounters (fights). Additionally, we studied whether a stressful white-noise exposure would alter this response to the aggressive encounters.Our study indicates that CTR-female rats are able to show third party prosocial behavior in response to witnessing aggressive encounters between conspecifics in a seminatural environment. In addition, we showed that perinatal FLX exposure impairs the display of prosocial behavior in female rats. Moreover, we found no signs of prosocial behavior in CTR- and FLX-males after natural aggressive encounters. After white-noise exposure the effects in third party prosocial behavior of CTR-females ceased to exist. We conclude that female rats are able to show prosocial behavior, possibly in the form of consolation behavior. In addition, the negative effects of perinatal fluoxetine exposure on prosocial behavior could provide additional evidence that SSRI treatment during pregnancy could contribute to the risk for social impairments in the offspring.

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Section: Introductionmentioning

confidence: 61%

Section: Methodsmentioning

confidence: 99%

“…These littermates had been housed in different home cages since weaning. Details of the litter distribution in the cohorts can be found in the supplemental materials of [31].…”

Section: Design Of the Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure

Heinla

Heijkoop

Houwing

et al. 2019

Preprint

Self Cite

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Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5‐HT expression in male and female adult Wistar rats

Linhares

Meurer

Aquino

et al. 2022

Intl J of Devlp Neuroscience

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Serotonin (5-HT) reuptake inhibitors, such as fluoxetine, are the most prescribed antidepressant for maternal depression. In this sense, it exposes mothers and the brains of infants to increased modulatory and trophic effects of serotonergic neurotransmission. 5-HT promotes essential brain changes throughout its development, which include neuron migration, differentiation and organisation of neural circuitries related to emotional, cognitive and circadian behavior. Early exposure to the SSRIs induces long-term effects on behavioral and neural serotonergic signalisation. We have aimed to evaluate the circadian rhythm of locomotor activity and the neurochemical content, neuropeptide Y (NPY) and 5-HT in three brain areas: intergeniculate leaflet (IGL), suprachiasmatic nuclei (SCN) and raphe nuclei (RN), at two zeitgebers (ZT6 and ZT18), in male and female rat's offspring early exposed (developmental period GD13-GD21) to fluoxetine (20 mg/kg). First, we have conducted daily records of the locomotor activity rhythm using activity sensors coupled to individual cages over 4 weeks. We have lastly evaluated the immunoreactivity of NPY in both SCN and IGL, as well the 5-HT expression in the dorsal and medial RN. In summary, our results showed that (1) prenatal fluoxetine affects phase entrainment of the rest/activity rhythm at ZT6 and ZT18, more in male than female specimens, and (2) modulates the NPY and 5-HT expression. Here, we show male rats are more susceptible to phase entrainment and the NPY and 5-HT misexpression compared to female ones. The sex differences induced by early exposure to fluoxetine in both the circadian rhythm of locomotor activity and the neurochemical expression into SCN, IGL and midbrain

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Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice

et al. 2020

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Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment

Cited by 21 publications

References 62 publications

Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure

Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure

Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5‐HT expression in male and female adult Wistar rats

Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice

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