Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice

Bellia, Fabio; Suarez, Andrea Beatriz; D’Addario, Claudio; Pautassi, Ricardo Marcos; Fabio, María Carolina

doi:10.1007/s00213-020-05670-1

Cited by 8 publications

(6 citation statements)

References 63 publications

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“…There is abundant evidence to implicate the serotonin in the neurobiology of drugs of abuse (review Müller and Homberg 2015 ) although its precise role is complex, particularly as pharmacological, and genetic alterations in 5-HT neurotransmission can lead to opposite effects. Bellia et al ( 2020 ) pre-treated animals with the 5-HT depleting agent p-chloro-phenylalanine (PCPA) and found that PCPA treatment significantly reduced ethanol intake. Extrapolating this, our study uses a SERT haploinsufficient model which allows for subtler variations between groups and provides a strong framework for assessing the effect of altered serotonin levels.…”

Section: Discussionmentioning

confidence: 99%

Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol

et al. 2022

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Rationale Alcohol use disorder (AUD) is shown to have an overall heritability of around 50%. One of the genes associated with AUD is SLC6A4 (solute carrier family 6 member A4) which codes for the serotonin transporter (SERT). The study looked at serotonin dysfunction on ethanol consumption in adolescents and the subsequent intergenerational effects of drinking by using a rat model: SERT+/+ (regular functioning), SERT+/− (50% transporter reduction) and SERT−/− (complete reduction). Objectives We investigated sex and genotype differences in ethanol consumption in SERT knock-out Wistar rats (F0) followed by studying behaviour in the offspring (F1) of the male drinkers to assess effects of paternal alcohol consumption. Methods An intermittent access two-bottle choice paradigm (IA2BC) was used to yield ethanol drinking behaviour in F0 adolescent Wistar rats. The highest drinking males were mated to alcohol-naive females and their offspring were compared with controls. Drinking behaviour (IA2BC) and ethanol-induced motor coordination effects (via rotarod) were measured in the F1s. Results F0 drinking saw no SERT genotype differences in males. However, females consumed higher volumes of ethanol compared to males, with SERT−/− females showing the highest intake. A clearer genotype effect was seen in the F1 animals, with reduction in SERT activity leading to enhanced ethanol intake in both sexes. Importantly, paternal exposure to ethanol significantly reduced the ethanol induced motor side effects in offspring, independent of sex and genotype. Conclusions These indicate a difference in the way genetic factors may act across sexes and suggest the involvement of epigenetic mechanisms in the intergenerational effects of alcohol.

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Section: Discussionmentioning

confidence: 99%

Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol

et al. 2022

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“…Of course, the relationship between gender, age， and the volume of alcohol abuse cannot be ignored. Relevant issues have been discussed in depth as well [11].…”

Section: Conclusion and Discussionmentioning

confidence: 99%

How Alcohol Consumption Affects Labor Supply?

Hu¹,

Sheng²,

Zhang³

et al. 2021

Proceedings of the 2021 International Conference on Financial Management and Economic Transition (FMET 2021)

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The purpose of this research is to understand the impact of drinking on the labor market. The data set comes from the National Longitudinal Survey of Youth 1989 and 1994 (NLSY89, NLSY94), which includes information about 12,686 individuals restricted to young adults with the age between 24 and 32 in 1989. The data was collected by a sample survey, and it was mainly investigated by dependent variables such as the amount of alcohol consumed. It is found through our research that moderate drinking is beneficial to labor supply by using Ordinary Least Squares, Two-Stage Least Squares, and Instrumental Variable-Probit models. However, excessive drinking still has a huge impact on labor. The main importance of this research is to explore the impact of alcohol on the labor market.

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“…The activation of 5‐HT2A receptor increases anxiety behavior in stress response to environmental changes (Ju et al., 2020). It is known from the KEGG results that the drug participates in the 5‐HT pathway, 5‐HT is considered to be an important substance that induces anxiety, and it is an important detection indicator in anxiety diseases (Bellia et al., 2020; Wang et al., 2019). According to the literature, in anxiety disorders LRRK2 is related to 5‐HT, and mutations in LRRK2 induce 5‐HT changes (Lim et al., 2018; Wile et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

Action mechanism of Roman chamomile in the treatment of anxiety disorder based on network pharmacology

et al. 2020

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Anxiety disorder is a common psychiatric disease. Roman chamomile as medicine or tea has long been used as a mild tranquilizer to reduce anxiety, but the mechanism is unclear. This research is based on network pharmacology combined with database mining to find the ingredients, action pathways and key targets of Roman chamomile for the treatment of anxiety. About 126 common targets related to chamomile and anxiety were obtained, and these targets were involved in 56 KEGG pathways. GEO screened LRRK2 as a key protein, and molecular docking showed that the protein could stably bind to drug components. Roman chamomile has the characteristics of multi-target and multi-pathway in the treatment of anxiety disorder. Its possible mechanism is to intervene anxiety disorder in the process of disease development, such as neuroactive ligand-receptor interaction, serotonin synapse, and cAMP signaling pathway. LRRK2 may be an important gene for Roman chamomile in the treatment of anxiety disorder. Practical applications Roman chamomile is well known for its use in medicine and tea making. It contains many nutrients, which can relieve people's anxiety, help sleep, antibacterial and antiinflammatory. In this article, through network pharmacology combined with Gene Expression Omnibus data mining and molecular docking, the target and mechanism of Roman chamomile in the treatment of anxiety were discussed, and its efficacy was verified by model animals, which not only clarified its mechanism at the systematic level, but also proved to be effective at the biological level. It provides a reference for the further development and utilization of Roman chamomile.

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Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice

Cited by 8 publications

References 63 publications

Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol

Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol

How Alcohol Consumption Affects Labor Supply?

Action mechanism of Roman chamomile in the treatment of anxiety disorder based on network pharmacology

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