2000
DOI: 10.1590/s0100-879x2000000700002 View full text |Buy / Rent full text
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Abstract: A growing body of evidence supports the concept of fetal programming in cardiovascular disease in man, which asserts that an insult experienced in utero exerts a long-term influence on cardiovascular function, leading to disease in adulthood. However, this hypothesis is not universally accepted, hence animal models may be of value in determining potential physiological mechanisms which could explain how fetal undernutrition results in cardiovascular disease in later life. This review describes two major animal… Show more

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“…The moderate zinc deficiency induced neither growth retardation nor changes in food intake. There are not enough reports on the cardiovascular effects of moderate zinc deficiency in growing animals, even though there is evidence, from animal studies, that postnatal environment may be of great importance in determining adult BP (31). Our experimental data demonstrated that moderate zinc deficiency during growth induces an increase in SBP from day 30 after initiation of the dietary treatment, reaching values Ͼ140 mm Hg at the end of the experimental period.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…The moderate zinc deficiency induced neither growth retardation nor changes in food intake. There are not enough reports on the cardiovascular effects of moderate zinc deficiency in growing animals, even though there is evidence, from animal studies, that postnatal environment may be of great importance in determining adult BP (31). Our experimental data demonstrated that moderate zinc deficiency during growth induces an increase in SBP from day 30 after initiation of the dietary treatment, reaching values Ͼ140 mm Hg at the end of the experimental period.…”
Section: Discussionmentioning
“…which may interfere in the development phases, such as malnutrition, may favor the onset of cardiovascular pathologies in late phases of life. The mechanisms which promote such alterations have not been totally elucidated (3) , although such vascular pathologies have already been related to alterations in the structure of vessels, notably to alterations on the arterial wall (24) . The multi-needy malnutrition used in this study during the lactation period promoted reduction in the area of the tunica media of the horizontal aorta artery of 12-month rats, demonstrating that, although malnutrition has occurred in a very early phase of the animal's life, the alterations caused by it remained, reducing hence the thickness of the arterial wall.…”
Section: Methodsmentioning
“…Disorders occurred during this period may determine permanent or long-term alterations in different organs (3) . Among these disorders, we can stress the nutritional deficiencies which, associated with unfavorable socieconomical conditions (4) , may be related to high risk of development of defects in metabolism, as well as trigger diseases such as type diabetes, obesity (5) , systemic arterial hypertension (SAH), as well as cardiovascular diseases in more advanced ages (6,7) .…”
Section: Introductionmentioning
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“…Experimental undernutrition using a diet mimicking that widely used by human beings in these regions [2] leads to alterations in renal structure and function [3], including those related to angiotensin II-modulated renal fluid handling [4] that could be associated with the onset of hypertension in adulthood. Maternal dietary restriction using different protocols has demonstrated programming of renal lesions in cortex and medulla that could be involved in alterations of renovascular responses [5][6][7], although the role of the kidney in perinatal programming of long-term alterations of arterial blood pressure has had only minor attention until recently [8].…”
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