Perinatal conditions and infant development in children with schizophrenic parents

Mednick, Sarnoff A.; Mura, Elaine L.; Schulsinger, Fini; Mednick, Birgitte R.

doi:10.1080/19485565.1982.9988499

Cited by 79 publications

(50 citation statements)

References 4 publications

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“…The Pittsburgh (Ragins et al, 1975), Danish Birth Cohort (Mednick, Mura, Schulsinger, & Mednick, 1971), and Israeli Infant (Marcus, Auerbach, Wilkinson, & Burack, 1981) studies also offer evidence of deviant neuromotot development in infants of schizophrenic parents. Marcus et al (1981) have emphasized that in their sample and in the samples of Fish (1984) and Ragins et al (1975) approximately one-half of the high-risk infants showed signs suggestive of neurointegrative dysfunction.…”

Section: Neurological and Motoric Functioningmentioning

confidence: 94%

Biobehavioral risk factors in children of schizophrenic parents

Erlenmeyer‐Kimling

Cornblatt

1984

J Autism Dev Disord

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Research on risk factors for schizophrenia is reviewed with emphasis on children of schizophrenic parents. As children of schizophrenic parents are not representative of the majority of individuals who become schizophrenic, examination of variables such as those relating to home environment or parental characteristics in these children is not expected to contribute greatly to an understanding of risk for schizophrenia or to the search for early indicators of a genetic liability, whereas study of selected biobehavioral variables may do so. Four areas of biobehavioral functioning that have been examined in high-risk research are discussed. Three of these are considered to be compatible with the hypothesis of a neurointegrative defect underlying schizophrenia-proneness and to be promising for further research.

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Section: Neurological and Motoric Functioningmentioning

confidence: 94%

Biobehavioral risk factors in children of schizophrenic parents

Erlenmeyer‐Kimling

Cornblatt

1984

J Autism Dev Disord

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“…• Obstetrical complications at birth of infants at risk have been reported by numerous investigators (McNeil & Kaij, 1978;Mednick, Mura, Schulsinger, & Mednick, 1971), but the specificity of this finding to schizophrenia as opposed to the severity of the mother's illness irrespective of her type of disorder has been debated (Sameroff, Seifer, & Zax, 1982).…”

Section: Children At Risk For Schizophreniamentioning

confidence: 95%

Risk, Vulnerability, and Protective Factors in Developmental Psychopathology

Masten

Garmezy

1985

Advances in Clinical Child Psychology

397

265

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“…31, 1961, at Rigshospitalet in Copenhagen (15). In 1972, a sample of 265 11-13-year-old children from this cohort was intensively examined (16). Of this sample, 242, falling into three groups, were available for follow-up examinations at ages 31-33.…”

Section: Diagnostic Methods: the Parentsmentioning

confidence: 99%

Childhood Videotaped Social and Neuromotor Precursors of Schizophrenia: A Prospective Investigation

Schiffman

Walker²,

Ekstrøm³

et al. 2004

AJP

145

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Objective:The authors examined videotaped behaviors of children who developed schizophrenia as adults and of comparison subjects to disclose possible social and neuromotor deficits foreshadowing later development of schizophrenia. Method:In 1972, a sample of 265 11-13-year-old Danish children were filmed under standardized conditions while they were eating lunch. The examination was part of a larger study investigating early signs of schizophrenia spectrum disorders. Many of the subjects had a parent with schizophrenia, leaving them at high risk for developing a schizophrenia spectrum disorder. In 1991, adult psychiatric outcome data were obtained for 91.3% (N=242). This study systematically analyzed the videotapes to determine whether the children who developed schizophrenia as adults evidenced greater social and/or neuromotor deficits than children who did not develop a psychiatric disorder and children who developed other psychiatric disorders. Results:The findings from this study suggest that the brief videotaped footage of children eating lunch was able to discriminate between the individuals who later developed schizophrenia and those who did not. Specifically, the preschizophrenia children evidenced differences on measures of sociability and general neuromotor functioning (among boys) from the children who developed other psychiatric disorders and the children who did not develop a psychiatric disorder. Conclusions:Social and neuromotor deficits specific to children who develop schizophrenia in adulthood provide further support for a neurodevelopmental hypothesis of schizophrenia. The majority of individuals with schizophrenia manifest the illness in the second or third decade of life (1), yet subclinical signs of neuropathology are already evident during adolescence (2) and possibly as early as birth and infancy (3-5). Although some research suggests that the early signs of schizophrenia are nonspecific and that no one sign predicts schizophrenia uniquely and effectively (6), other studies indicate that both social and neuromotor abnormalities in childhood are reliable developmental precursors of the disorder.Social deficits exhibited before the onset of schizophrenia suggest that interpersonal difficulties precede recognizable psychotic symptoms. A unique study by Walker and colleagues (7) evaluated childhood home movies of schizophrenia patients and comparison subjects. The authors reported that girls who later developed schizophrenia showed fewer expressions of joy than did same-sex comparison subjects from infancy through adolescence; preschizophrenia boys showed nonsignificantly more negative expressions in preadolescence and early adolescence.Longitudinal study of "high-risk" individuals (those having at least one parent with schizophrenia) provides an alternative opportunity to view the developmental course of schizophrenia. Several investigations have followed high-risk subjects through the age of risk, providing information regarding premorbid functioning and adult diagnostic outcome. In an inve...

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Perinatal conditions and infant development in children with schizophrenic parents

Cited by 79 publications

References 4 publications

Biobehavioral risk factors in children of schizophrenic parents

Biobehavioral risk factors in children of schizophrenic parents

Risk, Vulnerability, and Protective Factors in Developmental Psychopathology

Childhood Videotaped Social and Neuromotor Precursors of Schizophrenia: A Prospective Investigation

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