Perinatal CBD or THC Exposure Results in Lasting Resistance to Fluoxetine in the Forced Swim Test: Reversal by Fatty Acid Amide Hydrolase Inhibition

Maciel, Izaque de Sousa; Abreu, Gabriel H Dias de; Johnson, Claire T; Bonday, Rida; Bradshaw, Heather B.; Lu, Hui-Chen

doi:10.1089/can.2021.0015

Cited by 15 publications

(31 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that maternal exposure to low CBD increases body weight, an effect observed only in males. This sex difference may be linked to differential levels of brain CBD in embryos exposed to CBD (11). In the sole other study that tested in utero CBD, no change in the body weight was found in the progeny after weaning or during adulthood (11).…”

Section: Discussionmentioning

confidence: 88%

“…This sex difference may be linked to differential levels of brain CBD in embryos exposed to CBD (11). In the sole other study that tested in utero CBD, no change in the body weight was found in the progeny after weaning or during adulthood (11). This discrepancy may be due to different dam strains (C57BL6/J vs CD1), the time of observation of pups' growth, or both.…”

Section: Discussionmentioning

confidence: 92%

“…Control dams (SHAM) were injected the same volume of vehicle solution. This dose of CBD reaches the embryonic brain and cause some behavioral changes in the offspring (11). For each litter, the date of birth was designated as postnatal day (PND) 0.…”

Section: Animalsmentioning

confidence: 99%

“…CBD crosses the placenta and alters its very structure, both of which can have a significant impact on pregnancy outcomes (8)(9)(10). Moreover, a recent study showed that extended exposure of CD1 mice to CBD spanning from gestation through the first week after birth alters repetitive and hedonic behaviors in the adult progeny (11). The paucity of preclinical data on the impact of in utero CBD exposure prompted us to investigate the postnatal impact of gestational CBD exposure to assess potential risks associated with CBD use during this period.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

Iezzi

Caceres-Rodriguez

Chavis

et al. 2022

Preprint

View full text Add to dashboard Cite

Cannabidiol (CBD), one of the main components of cannabis, is generally considered safe, despite the lack of studies on the possible consequences of its consumption during critical periods of neurodevelopment, including prenatal life. Although CBD crosses the placenta and its use during pregnancy is steadily increasing, the impact of gestational CBD exposure on early life is unknown. Here, we combined behavioral exploration and deep learning to assess how in utero exposure to low doses of CBD alters pre-weaning behaviors in mouse pups of both sexes. The data reveal that pups from CBD-treated dams exhibit sex-specific alterations in weight growth, homing behavior, and the syllabic repertoire of ultrasonic vocalizations. Thus, prenatal CBD is associated with alterations in innate behavioral responses and communication skills.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 92%

Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

Iezzi

Caceres-Rodriguez

Chavis

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…CBD crosses the placenta and alters its very structure, both of which can have a signi cant impact on pregnancy outcomes (8-10). Moreover, a recent study showed that extended exposure of CD1 mice to CBD spanning from gestation through the rst week after birth alters repetitive and hedonic behaviors in the adult progeny (11). The paucity of preclinical data on the impact of in utero CBD exposure prompted us to investigate the postnatal impact of gestational CBD exposure to assess potential risks associated with CBD use during this period.…”

Section: Introductionmentioning

confidence: 99%

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

Manzoni

Iezzi

Caceres-Rodriguez

2022

Preprint

View full text Add to dashboard Cite

show abstract

Prenatal Exposure to Cannabis: Effects on Childhood Obesity and Cardiometabolic Health

Moore

2024

Curr Obes Rep

View full text Add to dashboard Cite

Purpose of Review To consolidate information on the obesogenic and cardiometabolic effects of prenatal exposure to cannabis. Recent Findings A PubMed search strategy updated from January 1, 2014, through 14 June 2023, produced a total of 47 epidemiologic studies and 12 animal studies. Prenatal exposure to cannabis is consistently associated with small for gestational age and low birth weight. After birth, these offspring gain weight rapidly and have increased adiposity and higher glucose (fat mass percentage) in childhood. More preclinical and prospective studies are needed to deepen our understanding of whether these associations vary by sex, dose, timing, and composition of cannabis (e.g., ratio of delta-Δ9-tetrahydrocannabinol [Δ9-THC] to cannabidiol [CBD]). Addressing these gaps may help to solidify causality and identify intervention strategies. Summary Based on the available data, clinicians and public health officials should continue to caution against cannabis use during pregnancy to limit its potential obesogenic and adverse cardiometabolic effects on the offspring.

show abstract

Perinatal CBD or THC Exposure Results in Lasting Resistance to Fluoxetine in the Forced Swim Test: Reversal by Fatty Acid Amide Hydrolase Inhibition

Cited by 15 publications

References 71 publications

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

Prenatal Exposure to Cannabis: Effects on Childhood Obesity and Cardiometabolic Health

Contact Info

Product

Resources

About