Perinatal asphyxia, hyperthermia and hyperferremia as factors inducing behavioural disturbances in adulthood: A rat model

Caputa, M; Rogalska, Justyna; Wentowska, K; Nowakowska, Anna

doi:10.1016/j.bbr.2005.05.015

Cited by 34 publications

(33 citation statements)

References 40 publications

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“…This fact, in addition to the normal neurological scores, suggests that the mice are still fundamentally healthy. Our fear conditioning data are consistent with the report of Caputa et al, (2005) who stated that perinatal anoxia in rats resulted in reduced attention to potential dangers as adults. More interesting is the result in Fig.…”

Section: Emotional Responsivenesssupporting

confidence: 92%

“…Following anoxia consequent to stroke and other causes such as cardiac failure, drowning, carbon monoxide exposure and various accidents, there is a complex cascade of events in neurons causing cell death and functional neurological damage (Neubauer and Sunderram, 2004;Clarkson et al, 2005;Lo et al, 2005;Rashidian et al, 2005). Altered functional states include arousal, attention, intention, memory and awareness, all observed during global disorders of consciousness (Vexler et al, 1994;Schiff and NY, 10021, Telephone: 212-327-8668, Fax: 212-327-8664, E-mail: iarrieta@mail.rockefeller.edu.2000; Glenn et al, 2003;Dunham et al, 2004;Laureys et al, 2004;Young et al, 2004;Caputa et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Mouse model of diffuse brain damage following anoxia, evaluated by a new assay of generalized arousal

Arrieta‐Cruz¹,

Pfaff²,

Shelley³

2007

Experimental Neurology

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Diffuse brain damage following anoxia due to cardiac failure, drowning, carbon monoxide exposure or other accidents constitutes a major medical problem. We have created a novel mouse model using the breathing of pure nitrogen, followed by a recently developed assay that reflects an operational definition of generalized arousal. The operational definition is precise, complete, and leads to quantitative, physical measures in a genetically tractable animal. Exposure to pure nitrogen for controlled periods had a surprising bifurcate effect: about half the mice survived with neurological measures that were virtually normal while the other half died. The new assay detected behavioral deficits unrevealed by neurological screening. Two important features of the results were that (i) deficits were not equal across the circadian cycle, and (ii) deficits were not equal across all the measures within the operational definition of arousal. Specific voluntary motor measurements were decreased in a manner that depended on the phase of the circadian cycle. Sensory responses were also decreased, with an emphasis on vertical movement responses; but, interestingly, fear learning was not damaged. This study establishes the first useful approach to diffuse brain damage in a genetically tractable animal. The model and its outcome measurements will be useful during future attempts at amelioration of acquired neurological disabilities following hypoxic-ischemic injuries.

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Section: Emotional Responsivenesssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Mouse model of diffuse brain damage following anoxia, evaluated by a new assay of generalized arousal

Arrieta‐Cruz¹,

Pfaff²,

Shelley³

2007

Experimental Neurology

View full text Add to dashboard Cite

show abstract

“…Alterações nessa região decorrentes de estímulos anóxicos podem resultar em déficits motores, cognitivos e distúrbios neuro-comportamentais, com prejuízo na aprendizagem e memória espacial (DELL'ANNA et al, 1997;IUVONE et al, 1996), que persistem por toda a vida. (CAPUTA et al, 2005;BUWALDA et al, 1995).…”

Section: Formação Hipocampalunclassified

“…Para a manutenção da temperatura dos neonatos, a câmara aquecida por resistência elétrica, fica parcialmente imersa em água a 3537 °C (esta faixa de temperatura é importante para potencializar os efeitos de anóxia), pois a temperatura basal dos neonatos é de 33 °C, o que constitui um fator de neuroproteção (ROGALSKA et al, 2006;CAPUTA et al, 2005). condições anóxicas é descrito como igual a 12,5% (TAKADA et al, 2011;IUVONE et al, 1996;DELL'ANNA et al, 1995;1991).…”

Section: Condições Experimentaisunclassified

“…O modelo experimental escolhido para provocar anóxia em neonatos, foi adaptado da literatura (ROGALSKA et al, 2006;TANG e NAKAZAWA, 2005;CAPUTA et al, 2005;LAVIOLA et al, 2004;DELL'ANNA et al, 1997;IUVONE et al, 1996;BUWALDA et al, 1995), e validado por nosso grupo de pesquisa (TAKADA et al, 2011). Entretanto, dentro de um mesmo grupo experimental a espessura foi constante.…”

Section: Condições Experimentaisunclassified

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Estudo da imunorreatividade da proteína S100b no Hipocampo e Núcleo do Trato Solitário de ratos neonatos submetido à anóxia.

Allemandi¹

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Critical Age Windows for Neurodevelopmental Psychiatric Disorders: Evidence from Animal Models

Marco¹,

Macrı̀²,

Laviola³

2010

Staging Neuropsychiatric Disorders

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Perinatal asphyxia, hyperthermia and hyperferremia as factors inducing behavioural disturbances in adulthood: A rat model

Cited by 34 publications

References 40 publications

Mouse model of diffuse brain damage following anoxia, evaluated by a new assay of generalized arousal

Mouse model of diffuse brain damage following anoxia, evaluated by a new assay of generalized arousal

Estudo da imunorreatividade da proteína S100b no Hipocampo e Núcleo do Trato Solitário de ratos neonatos submetido à anóxia.

Critical Age Windows for Neurodevelopmental Psychiatric Disorders: Evidence from Animal Models

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