Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis

Conforti, Alessandro; Picarelli, Silvia; Carbone, Luigi; Marca, Antonio La; Venturella, Roberta; Vaiarelli, Alberto; Cimadomo, Danilo; Zullo, Fulvio; Rienzi, Laura; Ubaldi, Filippo Maria

doi:10.1016/j.rbmo.2020.09.029

Cited by 21 publications

(17 citation statements)

References 88 publications

(100 reference statements)

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“…A meta-analysis on NC-IVF showed an increased risk for PTB (RR 1.32, 95% CI 1.05, 1.66) but not for LBW (RR 2.98, 95% CI 0.54, 16.29) after stimulated IVF (Kamath et al, 2018). Decreased risks of PTB and LBW following the transfer of frozen embryos could not only be related to cryopreservation, but to the fact that no gonadotropins are used in the cycle before the transfer (Conforti et al, 2021). Research comparing fresh NC-IVF with natural thawing cycles could bring more light on the specific impact of cryopreservation on perinatal outcomes.…”

Section: Interpretations Of Findingsmentioning

confidence: 97%

“…Gonadotropin stimulation also bears higher risks for the mother for ovarian hyperstimulation syndrome, pregnancy-induced hypertension, gestational diabetes mellitus and seems independently associated with preterm delivery (Pandey et al, 2012). Otherwise, singletons resulting from thawing cycles show significantly lower risks for PTB and LBW but higher risks for large for gestational age and high birthweight (Conforti et al, 2021;Maheshwari et al, 2018;Pontesilli et al, 2021). By postponing the embryo transfer in thawing cycles, the gonadotropins do not directly affect the pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Perinatal outcomes in singletons after fresh IVF/ICSI: results of two cohorts and the birth registry

Mitter

Fasel

Berlin

et al. 2022

Reproductive BioMedicine Online

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Section: Interpretations Of Findingsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Perinatal outcomes in singletons after fresh IVF/ICSI: results of two cohorts and the birth registry

Mitter

Fasel

Berlin

et al. 2022

Reproductive BioMedicine Online

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show abstract

“…This approach dramatically reduced the risk of OHSS and, at the same time, offered the possibility to transfer the embryos in a more physiological environment. Recent meta-analyses suggest that the transfer of cryopreserved embryos is associated with favorable perinatal outcomes (35)(36)(37)(38).…”

Section: Frozen-thawed Embryo Transfer (Fet)mentioning

confidence: 99%

Luteal Phase Support Using Subcutaneous Progesterone: A Systematic Review

Conforti

Carbone

Iorio

et al. 2021

Front. Reprod. Health

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Luteal phase support (LPS) is crucial in assisted reproductive technology (ART) cycles when the luteal phase has been found to be defective. Such deficiency is most likely related to the supraphysiological steroid levels that usually occurr in stimulated cycles which, in turn, could severely affect luteinizing hormone (LH) secretion and function, thereby negatively influencing the luteal phase. A number of different medications and routes have been successfully used for LPS in ART. Although an optimal protocol has not yet been identified, the existing plethora of medications offer the opportunity to personalize LPS according to individual needs. Subcutaneous administration progesterone has been proposed for LPS and could represent an alternative to a vaginal and intramuscular route. The aim of the present systematic review is to summarize the evidence found in the literature concerning the application of subcutaneous progesterone in ARTs, highlighting the benefits and limits of this novel strategy. With this aim in mind, we carried out systematic research in the Medline, ISI Web of Knowledge, and Embase databases from their inception through to November 2020. Randomized controlled trials (RCTs) were preferred by the authors in the elaboration of this article, although case-control and cohort studies have also been considered. According to our findings, evidence exists which supports that, in women with a good prognosis undergoing a fresh in vitro fertilization (IVF) cycle, subcutaneous Pg is not inferior to vaginal products. In the Frozen-thawed embryo transfer (FET) cycle, data concerning efficacy is mixed with an increased miscarriage rate in women undergoing a subcutaneous route in oocyte donor recipients. Data concerning the acceptance of the subcutaneous route versus the vaginal route are encouraging despite the different scales and questionnaires which were used. In addition, a cost-effective analysis has not yet been conducted.

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“…In addition, LGA is associated with a high risk of offspring obesity and depression ( 5 , 6 ). Previous findings have indicated that frozen embryo transfer (FET) is associated with a higher birthweight and an increased risk of delivering LGA babies as compared to fresh embryo transfer ( 7 , 8 ), implying that the process of cryopreservation can adversely affect the embryo quality and developmental potential. Moreover, FET at the blastocyst stage is associated with higher birthweight and an increased risk of LGA compared with the cleavage stage ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Birthweight After Frozen Embryos Formed on the Fifth Day Versus the Sixth Day: A Retrospective Analysis Including 17,127 Singleton Newborns

et al. 2022

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BackgroundTransferring blastocysts frozen on day 6 (D6) may adversely affect the pregnancy rate compared with day 5 (D5). Moreover, it remains unclear whether delayed embryo transfer affects neonatal birth weight.MethodsA retrospective cohort study consisting of 17,127 singleton births from single frozen embryo transfer (FET) cycles, between January 2011 and January 2020, was performed including 14,166 blastocysts frozen on D5 and 2,961 on D6. The primary outcomes of this study were neonatal birth weight and incidence of small for gestational age (SGA), large for gestational age (LGA), low birth weight (LBW), and macrosomia.ResultsThe mean neonatal birth weight in the D5 group (3.47 ± 0.49 kg) was significantly higher compared with the D6 group (3.45 ± 0.50 kg), although the discrepancy was only 0.02 kg. Multiple linear regression analysis for birth weight between the two groups showed no statistically significant difference (β= -0.01 t= -1.218; P>0.05). Logistic regression analysis revealed that the risks of SGA (OR 1.166; 95%CI, 0.911-1.491; P>0.05), LGA (OR 0.917; 95%CI, 0.831-1.012; P>0.05), LBW (OR 1.192; 95%CI, 0.926-1.533; P>0.05), and macrosomia (OR 0.975; 95%CI, 0.864-1.100; P>0.05) were similar in the two groups after adjusting for confounders.ConclusionsIn the FET cycle, the neonatal birth weight and incidence of LGA, SGA, LBW, or macrosomia were similar between the D5 and D6 groups, suggesting that delayed blastocyst transfer would not affect the neonatal birth weight.

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Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis

Cited by 21 publications

References 88 publications

Perinatal outcomes in singletons after fresh IVF/ICSI: results of two cohorts and the birth registry

Perinatal outcomes in singletons after fresh IVF/ICSI: results of two cohorts and the birth registry

Luteal Phase Support Using Subcutaneous Progesterone: A Systematic Review

Birthweight After Frozen Embryos Formed on the Fifth Day Versus the Sixth Day: A Retrospective Analysis Including 17,127 Singleton Newborns

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