Perinatal and long‐term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systematic review and meta‐analysis

Scala, Carolina; Familiari, Alessandra; Pinas, Ana; Papageorghiou, Aris T.; Bhide, A.; Thilaganathan, B.; Khalil, Asma

doi:10.1002/uog.15943

Cited by 48 publications

(46 citation statements)

References 30 publications

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“…Several studies suggest an association between the severity of ventriculomegaly and poor outcome. In this study, we found no statistical difference in atrial width when comparing children with and those without a neurodevelopmental disorder.…”

Section: Discussioncontrasting

confidence: 71%

Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally

Thorup

Jensen

Bak

et al. 2019

Ultrasound in Obstet & Gyne

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Section: Discussioncontrasting

confidence: 71%

Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally

Thorup

Jensen

Bak

et al. 2019

Ultrasound in Obstet & Gyne

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“…This investigation has only recently become available in clinical practice and may not have been available for the series included in this review. Also, fetal MRI is able to diagnose additional brain abnormalities in 5% of cases 33 , but only in the last decade has it been introduced gradually as an additional fetal central nervous system investigation. Some of the apparently isolated cases may no longer have been classified as isolated had they undergone chromosomal microarray analysis, fetal MRI or appropriate neurosonography according to the current standard guidelines (International Society of Ultrasound in Obstetrics and Gynecology guidelines) 2 .…”

Section: Summary Of Evidencementioning

confidence: 99%

Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: systematic review and meta‐analysis

Carta

Agten

Belcaro

et al. 2018

Ultrasound in Obstet & Gyne

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Four-fifths of fetuses with severe ventriculomegaly survive and, of these, just over two-fifths show normal neurodevelopment. The overall survivors without disability account for more than one third of the total. Given that many cases undergo termination of pregnancy and require longer follow-up in order to detect subtle abnormalities, mortality and prevalence of developmental delay may be even higher than that reported in this paper. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

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“…The etiology of VM is complex, including obstruction of cerebrospinal fluid flow, focal or generalized brain volume loss, and deformities secondary to the CNS. 9 Due to variations in classification criteria, followup time, and evaluation methods of VM, there is no consensus on appropriate prognostic evaluation of fetuses. Furthermore, research has typically focused on the associated deformities of fetuses after birth, rather than neurodevelopmental retardation.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of fetuses with ventriculomegaly: An observational retrospective study

et al. 2019

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Objective To investigate the prognosis of fetuses with ventriculomegaly (VM). Methods Clinical data were collected from 234 cases of fetal VM diagnosed by ultrasound between March 2010 and July 2016. VM progression was monitored, and karyotyping and infection screening performed. Magnetic resonance imaging (MRI) was performed where increasing ventricular diameter was noted. Neonatal behavioral neurological assessment (NBNA) was carried out after birth, and Bayley Scales of Infant Development assessment at 6 months. Results The in utero outcomes of Group A were better than Group B in 173 pregnancies. Isolated VM (IVM) was associated with better prognosis than nonisolated VM (NIVM); the regression rates were 74.6% (59/79) and 52.1% (49/94), respectively (χ2 = 10.222, .006). The NBNA scores were significantly higher in Group A than Group B (χ2 = 4.231, .004), but not significantly different between IVM and NIVM. The composition ratios of both the psychomotor and mental developmental index (PDI and MDI) scores were not significantly different between Groups A and B (Z = 1.869, .062 and Z = 0.826, .409, respectively). Significant differences in in utero outcomes were observed between IVM and NIVM cases in Groups A and B. Conclusions Fetal VM prognosis is affected by the width of ventricle, chromosome abnormalities, coexisted abnormalities, and in utero progression.

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Perinatal and long‐term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systematic review and meta‐analysis

Abstract: Objectives

Cited by 48 publications

References 30 publications

Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally

Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally

Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: systematic review and meta‐analysis

Prognosis of fetuses with ventriculomegaly: An observational retrospective study

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