The detection rate of CoA may improve when a multiple-criteria prediction model is adopted. Further large multicenter studies sharing the same imaging protocols are needed to develop objective models for risk assessment in these fetuses.

We describe a new formulation for a hydrophilic resin, mostly composed of glycol methacrylate and hydroxypropyl methacrylate and here referred to as bioacryl, that allows the performance of morphological and immunohistochemical investigations at both light and electron microscopic levels. Immunolocalizations performed on bioacryl-embedded tissues are characterized by high specificity with virtually absent background staining. Finally, the new resin yields satisfactory fine-structural preservation, resulting in ultrastructural images of better quality than those obtained with Lowicryl K4M.

Objectives (pooled LR+ = 26.93, 95% CI,, P for effect < 0.001, P for Q = 0.3, I 2 = 17.3%), whereas normal RSA is a significant protective marker 95% CI,, P for effect = 0.043, P for Q = 0.9, I 2 = 0%). Conclusions