Perinatal acquisition of cervical cancer‐associated papillomaviruses

Cason, John

doi:10.1111/j.1471-0528.1996.tb09900.x

Cited by 22 publications

(19 citation statements)

References 66 publications

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“…Perinatal transmission has been regarded as the most likely explanation for the presence of HPV in newborns. Several studies have shown that children born to HPV-positive mothers have a higher risk of becoming HPV positive (24)(25)(26)(27)(28)(29)(30)(31). A meta-analysis on 3,128 mother-child pairs showed that children of HPV-positive mothers were 33% more likely to be HPV positive than were children born to HPV-negative mothers.…”

Section: Transmission Of Oral Hpv Infectionmentioning

confidence: 99%

Oral manifestations of human papillomavirus infections

Syrjänen

2018

European J Oral Sciences

120

144

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Papillomaviruses are one of the oldest viruses known, dating back 330 million years. During this long evolution, human papillomaviruses (HPV) have developed into hijackers of human cellular and immune systems in which they replicate and remain silent. Systematic studies on oral HPV infections and their outcomes are still scarce. Oral HPV infections have been linked to sexual behaviour, but recent evidence supports their horizontal, mouth‐to‐mouth, transmission. Most HPV infections in infants are acquired vertically from the mother during the intrauterine period, during delivery, or later via saliva. The best‐known benign clinical manifestations of HPV infection are oral papilloma/condyloma and focal epithelial hyperplasia. Evidence is emerging which suggests that some oral HPV infections might persist. Persistent HPV infection is mandatory for HPV‐associated malignant transformation. However, progression of HPV‐induced lesions to malignancy requires additional cofactors. In the early 1980s, we provided the first evidence that a subset of oral cancers and other head and neck cancers might be causally linked to HPV infection. This review summarizes current knowledge on the virus itself, its transmission modes, as well as the full spectrum of oral HPV infections – from asymptomatic infections to benign, potentially malignant oral lesions, and squamous cell carcinoma.

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Section: Transmission Of Oral Hpv Infectionmentioning

confidence: 99%

Oral manifestations of human papillomavirus infections

Syrjänen

2018

European J Oral Sciences

120

144

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“…We did not attempt to obtain a group of women that had never been exposed to HPV-16. Firstly, because this virus is ubiquitous amongst sexually active women (IARC, 1995) and even sexually inexperienced women may be infected via nonsexual routes (Cason, 1996). Secondly, our primary goal was not to compare responses between those who were and those who were not exposed to HPV-16, but to determine whether immune responses to HPV-16 E5 occurred and were associated with lesion severity.…”

Section: Methodsmentioning

confidence: 99%

Proliferative T-cell responses to human papillomavirus type 16 E5 are decreased amongst women with high-grade neoplasia.

Gill

Bible

Biswas

et al. 1998

Journal of General Virology

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“…[25,27] More rarely, HPVs can be transmitted via perinatal transmission during birth from the mother to child that is also observed in the transmission of other microbial and viral infections. [28,29] Horizontal transmission of HPV is also possible and it was first reported with a 5 year old boy of HPV2 infection presented as warts on the hands and anus of the child via genital-finger transmission. [30] …”

Section: Transmission Of Hpvmentioning

confidence: 99%

The role of human papillomaviruses in cancer progression

Tulay¹,

Serakıncı²

2016

JCMT

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The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been taken. In the last decade, development of HPV vaccination has reduced the number of cases in HPV infections and infection induced cancers. In this report, we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.

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Perinatal acquisition of cervical cancer‐associated papillomaviruses

Cited by 22 publications

References 66 publications

Oral manifestations of human papillomavirus infections

Oral manifestations of human papillomavirus infections

Proliferative T-cell responses to human papillomavirus type 16 E5 are decreased amongst women with high-grade neoplasia.

The role of human papillomaviruses in cancer progression

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