Perillartine protects against metabolic associated fatty liver in high-fat diet-induced obese mice

Abstract

Metabolic associated fatty liver disease is the main cause of chronic liver disease in the world, but there is still no effective treatment.

Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

“…Eriocitrin, a natural flavonoid abundant in lemons, improves insulin sensitivity by attenuating hepatic gluconeogenesis [306]. Perillartine, a natural sweetener extracted from Perilla frutescens, improved lipid deposition and glucose homeostasis in hepatocytes by downregulating the expression of gluconeogenesis-related genes [307]. Fisetin, a natural flavonoid that exists in fruits and vegetables, can downregulate the expression levels of G6Pase and PEPCK and repair the high-fat diet-induced imbalance between hepatic glucose release and uptake [308].…”