Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites

He, Ziwen; Guo, Jingyan; Zhang, Huiwen; Yu, Jingjing; Zhou, Yiqing; Wang, Yajun; Li, Ting; Yan, Meiqiu; Li, Bo; Chen, Yigong; Chen, Suhong; Lv, Guiyuan; Su, Jie

doi:10.1016/j.ijbiomac.2023.126987

Cited by 9 publications

(3 citation statements)

References 69 publications

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“…It also prevented the overexpression of proinflammatory cytokines TNF-α, IL-1β, and IL-6, reduced neutrophil infiltration, and upregulated the expression of MUC2 and the tight junction protein claudin-1, thus attenuating DSS-induced intestinal mucosal barrier damage in mice. In a rat model administered A. macrocephala, He et al (2023b) observed an abundance of Lactobacillus and Rhodococcus species in the intestine, as well as an increase in tryptophan metabolites, such as indole, indole-3-propionic acid, and tryptophan. This, in turn, increased the expression of the intestinal AHR.…”

Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 98%

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yu,

Liu,

Meng

2024

Front. Pharmacol.

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The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration of anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes in the composition, abundance, and diversity of the gut microbiota (GM). Activation of multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), and bile acids (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component and multi-target advantages, can help treat AMD by altering GM composition and regulating the levels of certain substances, such as lipopolysaccharides, reducing oxysterols, and increasing SCFA and BA contents. This review explores the correlation between GM and AMD and interventions for the two to provide new perspectives on treating AMD with TCM.

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Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 98%

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yu,

Liu,

Meng

2024

Front. Pharmacol.

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“…IL-22 improves intestinal barrier function by upregulating tight junction proteins; thus, the AMP-mediated gut microbiota-tryptophan metabolism-AhR pathway is how this polysaccharide improves GMD. 101 In addition, it has been found that dietary intake of bran fiber may alleviate metabolic disorders and the gut microbiota in the body by regulating tryptophan metabolism. Specifically, bran increased the abundance of beneficial bacteria (e.g., Lactobacillus and Akkermansia) significantly associated with tryptophan-derived IPA, IAld.…”

Section: Reviewmentioning

confidence: 99%

Let food be your medicine – dietary fiber

Liu,

Li,

Cao

et al. 2024

Food Funct.

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“…TRP and its metabolites not only participate in protein synthesis [4] and improve intestinal morphology [5] but also regulate glycolipid metabolism [6]. The production of tryptophan metabolites by intestinal microorganisms reportedly occurs through the activation of aryl hydrocarbon receptors to improve glycolipid metabolism [7]. The kynurenine pathway is activated in the adipose tissues of obese patients [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Tryptophan Supplementation in Diets with Different Protein Levels on the Production Performance of Broilers

Xie,

Feng,

Zhu

et al. 2024

Animals

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Tryptophan plays an important role in the pig industry but has the potential to improve performance in the poultry industry. The purpose of this study was to examine the effects of tryptophan supplementation in diets with different protein levels on the feed intake, average daily gain (ADG), and feed conversion ratio (F/G) of broilers. A total of 180 twenty-one-day-old broilers (half male and half female) were weighed and randomly allocated to twelve groups, with six male and six female groups. Each group consisted of 15 broilers. The broilers were fed low- (17.2%), medium- (19.2%), or high- (21.2%) protein diets with or without extra tryptophan (up to 0.25%) during the 28-day experiment. Food intake and body weight were measured weekly during the trial period. Male broilers fed a medium-protein diet containing more tryptophan showed a lower F/G. In the low-protein diet groups, additional tryptophan caused a significant reduction in the feed intake of female broilers during the first two weeks. Moreover, the serum GLP-1, cholesterol, and bile acid levels, as well as the expression of FXR mRNA in the ileum, were significantly increased. Additionally, the FXR mRNA in the hypothalamus and the GCG and GLP-1R mRNAs in the ileum tended to increase in these broilers. In summary, the tryptophan concentration in the diet can influence the feed intake and metabolism of broilers. Under a standard diet, an appropriate amount of tryptophan is beneficial to the F/G of male broilers, while under a low-protein diet, tryptophan supplementation may cause a short-term reduction in the feed intake of female broilers by increasing serum GLP-1 and bile acid signals.

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Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites

Cited by 9 publications

References 69 publications

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Let food be your medicine – dietary fiber

Effects of Tryptophan Supplementation in Diets with Different Protein Levels on the Production Performance of Broilers

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