Perilla pomace obtained from four different varieties have different levels and types of polyphenols and anti-allergic activity

Gaihre, Yuba Raj; Iwamoto, Atsushi; Oogai, Shigeki; Hamajima, Hiroshi; Tsuge, Keisuke; Nagata, Yasuo; Yanagita, Teruyoshi

doi:10.1007/s10616-022-00522-6

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…In recent years, based on the inhibition of FcϵRI activation, naturally occurring anti-allergic substances that inhibit allergic reactions have been reported, such as tannins, catechins, peptides, and oligosaccharides [ 41 ]. Apigenin and luteolin in sesame and polyphenol extracts from the pomace of black and white sesame have also been reported to decrease the phosphorylation of Syk, PLCγ2, and Akt [ 42 ]. Resveratrol inhibits splenic tyrosine kinase (Syk) and phospholipase Cγ (PLCγ) in mast cells [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects

Takemoto,

Ganlin,

Iji

et al. 2024

Nutrients

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Food allergies are common worldwide and have become a major public health concern; more than 220 million people are estimated to suffer from food allergies worldwide. On the other hand, polyphenols, phenolic substances found in plants, have attracted attention for their health-promoting functions, including their anti-allergic effects. In this study, we examined the potential inhibitory effects of 80% ethanol extracts from 22 different vegetables on the degranulation process in RBL-2H3 cells. Our aim was to identify vegetables that could prevent and treat type I allergic diseases. We found strong inhibition of degranulation by extracts of perilla and chives. Furthermore, we verified the respective efficacy via animal experiments, which revealed that the anaphylactic symptoms caused by ovalbumin (OVA) load were alleviated in OVA allergy model mice that ingested vegetable extracts of perilla and chives. These phenomena were suggested to be caused by induction of suppression in the expression of subunits that constitute the high-affinity IgE receptor, particularly the α-chain of FcεR I. Notably, the anti-allergic effects of vegetables that can be consumed daily are expected to result in the discovery of new anti-immediate allergenic drugs based on the components of these vegetables.

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Section: Discussionmentioning

confidence: 99%

Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects

Takemoto,

Ganlin,

Iji

et al. 2024

Nutrients

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show abstract

“…In recent years, based on the inhibition of Fc RI activation, naturally occurring antiallergic substances that inhibit allergic reactions have been reported, such as tannins, catechins, peptides, and oligosaccharides [41]. Apigenin and luteolin in sesame and polyphenol extracts from the pomace of black and white sesame have also been reported to decrease the phosphorylation of Syk, PLCγ2, and Akt [42]. Resveratrol inhibits splenic tyrosine kinase (Syk) and phospholipase Cγ (PLCγ) in mast cells [43].…”

Section: Discussionmentioning

confidence: 99%

Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects

Takemoto,

Ganlin,

Iji

et al. 2024

Preprint

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Food allergies are common worldwide and have become a major public health concern; more than 220 million people are estimated to suffer from food allergies worldwide. On the other hand, polyphenols, phenolic substances found in plants, have attracted attention for their health-promoting functions, including their anti-allergic effects. In this study, we examined the potential inhibitory effects of 80% ethanol extracts from 22 different vegetables on the degranulation process in RBL-2H3 cells. Our aim was to identify vegetables that could prevent and treat type I allergic diseases. We found strong inhibition of degranulation by the extracts of perilla and chives. Furthermore, we verified the respective efficacy via animal experiments, which revealed that the anaphylactic symptoms caused by ovalbumin (OVA) load were alleviated in OVA allergy model mice that ingested vegetable extracts of perilla and chives. These phenomena were suggested to be caused by induction of suppression in the expression of subunits that constitute the high-affinity IgE receptor, particularly the α-chain of FcεR I. Notably, the anti-allergic effects of vegetables that can be consumed daily are expected to result in the discovery of new anti-immediate allergenic drugs based on the components of these vegetables.

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“…After processing, perilla skin and perilla pomace are usually considered waste and discarded. However, as these by-products have high nutritional value and contain phenolic compounds, carbohydrates, and proteins, various attempts have been made to develop methods to upcycle them [11][12][13][14]. Chumphukam et al also found that perilla seeds and perilla seed meal extracts exert potential anti-mutagenic, antioxidant, and anti-inflammatory effects, and RA was predominantly found in both extracts [15].…”

Section: Introductionmentioning

confidence: 99%

Physical Stability and Antioxidant Ability of a Sustainable Oil-in-Water Emulsion Containing Perilla Skin Extract and Upcycled Aquasoya Powder

Kang,

Yu,

Shin

2024

Foods

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In response to environmental issues, upcycling has become a growing trend in the food industry. Aquasoya is a promising method to upcycle by-product from soybean processing due to its high protein contents and excellent emulsifying ability. In the present research, Aquasoya powder was used an emulsifier to incorporate the antioxidant compounds from perilla skin extract (PSE), namely rosmarinic acid, into oil-in-water (O/W) emulsion system and its physochemical stability was assessed. As a result, droplet size of the emulsion was smaller in PSE-incorporated emulsion (PO, 350.57 ± 9.60 b nm) than the emulsion without PSE (PX, 1045.37 ± 142.63 a nm). Centrifugal photosedimentometry analysis also revealed that the physical stability was significantly improved in PO, and the stability was maintained over 30 d of storage. Furthermore, as PO had a higher ABTS radical scavenging ability and showed slower initial lipid oxidation, it was concluded that PO has a higher antioxidant ability than PX. Conclusively, Aquasoya can be considered as an emulsifier in O/W emulsion with PSE because it can effectively integrate and stabilize the antioxidant substance derived from perilla skin.

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Perilla pomace obtained from four different varieties have different levels and types of polyphenols and anti-allergic activity

Cited by 9 publications

References 23 publications

Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects

Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects

Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects

Physical Stability and Antioxidant Ability of a Sustainable Oil-in-Water Emulsion Containing Perilla Skin Extract and Upcycled Aquasoya Powder

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