Perichondral grafting for cartilage lesions of the knee

Gn, Homminga; Bulstra, S. K.; Bouwmeester, PS; Linden, AJ van der

doi:10.1302/0301-620x.72b6.2246280

Cited by 328 publications

(165 citation statements)

References 24 publications

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“…The early work of Pridie (40) clearly implicated the marrow space as a repository of reparative cells. Other authors used cartilage (3,45) or other tissues known to house chondroprogenitor cells (15,26,38,56) as implant material for articular surface defects. The development of cell isolation, culture, and cryopreservation techniques allowed the use of isolated cells for the repair of articular cartilage (5,6,9,13,18,19,39,43,51,52).…”

Section: A Solchaga Et a Lmentioning

confidence: 99%

Hyaluronan‐based polymers in the treatment of osteochondral defects

Solchaga

Yoo

Lundberg

et al. 2000

Journal Orthopaedic Research

211

131

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Summary: Articular cartilage in adults has limited ability for self-repair. Some methods devised to augment the natural healing response stimulate some regeneration, but the repair is often incomplete and lacks durability. Hyaluronan-based polymers were tested for their ability to enhance the natural healing response. It is hypothesized that hyaluronan-based polymers recreate an embryonic-like milieu where host progenitor cells can rcgcncrate the damaged articular surface and underlying bone. Oskochondral dcfccts were made on the femoral condyles of 4-month-old rabbits and were left empty or filled with hyaluronan-based polymers. The polymers tested were ACP sponge. made of crosslinked hyaluronan, and HYAFF-11 sponge, made of benxylated hyaluronan. The rabbits were killed 4 and 12 weeks after surgery, and the condyles were processed for histology. All 12-week defects were scored with a 29-point scale, and the scores were compared with a Kruskall-Wallis analysis of variance on ranks. Untreated defects filled with bone tissue up to or beyond the tidemark, and the noncalcified surface layer varied from fibrous to hyaline-like tissue. Four weeks aftcr surgery, defects treated with ACP exhibited bone filling to the level of the tidemark and the surface layer was composed of hyaline-like cartilage well integrated with the adjacent cartilage. At 12 weeks, the specimens had bone beyond the tidemark that was covered with a thin layer of hyaline cartilage. Four weeks after surgery, defects treated with HYAFF-11 contained a rim of chondrogcnic cells at the interface of the implant and the host tissue. In general, the 12-week dcfccts exhibited good bone fill and the surface was mainly hyaline cartilage. Treated defects received significantly higher scores than untreated defects (p < 0.05), and ACP-trcatcd defects scored significantly higher than HYAFF-11-treated defects (p < 0.05). The introduction of these hyaluronan-based polymers into delects provides an appropriate scaffolding and favorable microenvironnient for the reparative process. Further work is required to lully assess thc long-term outcome of defects treated with these polymers.The successful regeneration of any tissue requires not oiily reparative cells with the potential to differentiate into the phenotypes required to restore the damaged site but also a microenvironment that supports the proliferation and differentiation of those cells (12). It is our hypothesis that these reparative cells recapitulate, a t least in part. the sequence of events that leads to the formation of differentiated tissues during embryonic development; therefore. materials that mimic an embryonic environment may be superior scaffolds for tissue-engineered repair of damaged tissues.Articular cartilage has no vascular supply or easy access to large quantities of progenitor cells: thus, cartilage repair is often unsuccessful. Some studies indicate that full-thickness lesions in young animals are

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Section: A Solchaga Et a Lmentioning

confidence: 99%

Hyaluronan‐based polymers in the treatment of osteochondral defects

Solchaga

Yoo

Lundberg

et al. 2000

Journal Orthopaedic Research

211

131

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“…However, this procedure remains to be technically difficult and can result in variable patient outcomes based on differences in the height of the defect cartilage and the surrounding native cartilage as well as the accumulation of fibrocartilage within the gaps regions between the transplanted plugs [17,18]. For the repair of chondral defects, other implantation treatment methods involve grafting strips of perichondrium [19] or periosteum [20][21][22] to the defect using fibrin glue. In the case of periosteal grafts, the problem of graft calcification can occur over time.…”

Section: Tissue Implantationmentioning

confidence: 99%

Nanomaterials for cartilage tissue engineering

Chiu¹,

Waldman²

2016

Nanomaterials and Regenerative Medicine

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“…Perichondrial arthroplasty used for human cartilage repair was first described by Skoog et al [32]. This technique has been reported to give an initial cartilage repair in the defect [33,34]. On the long term poor results related to overgrowth of the graft and ossification are reported by Bouwmeester et al [26].…”

Section: Periosteal and Perichondrium Arthroplastymentioning

confidence: 99%

Cartilage Tissue Engineering; Lessons Learned From Periosteum

Emans¹

2011

J Tissue Sci Eng

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Cartilage, due to its unique physiology (lack of vasculature), can be potentially repaired using tissue engineered in the laboratory, by combining cells and with a supporting scaffold. This requires a marriage between material science, cell biology, and translational medicine, a concept well established as Tissue Engineering.Over the years the in vivo and in vitro chondrogenic potential of periosteum has been recognised by many researchers and as such periosteum is explored both to repair cartilage defects directly by transplanting periosteum into the cartilage defect or by using periosteum as a cell source for cartilage engineering purposes. The initial example hereof is the first generation of Autologous Chondrocyte Transplantation. Graft hypertrophy and ossification remain the primary drawbacks of cartilage repair strategies using engineered cartilage. These drawbacks may (partially) be due to the endochondral ossification process that can take over when cartilage is repaired. In this process chondrogenesis of progenitor cells is followed by hypertrophy of these cells and subsequent ossification. Periosteal progenitor cells go through this process in order to heal bone fractures. This review provides an overview of the role of periosteum in cartilage repair and cartilage tissue engineering and illustrates how periosteum can be used as a model to study the endochondral process. Such studies may provide clues to further optimize cartilage tissue engineering by identifying important factors which are capable of maintaining cells in their chondrogenic phenotype. Finally, the use of periosteum to engineer cartilage in vivo at an extra-articular site is described.

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Perichondral grafting for cartilage lesions of the knee

Cited by 328 publications

References 24 publications

Hyaluronan‐based polymers in the treatment of osteochondral defects

Hyaluronan‐based polymers in the treatment of osteochondral defects

Nanomaterials for cartilage tissue engineering

Cartilage Tissue Engineering; Lessons Learned From Periosteum

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