Nanomaterials for cartilage tissue engineering

Chiu, Loraine L. Y.; Waldman, Stephen D.

doi:10.5599/obp.9.2

Cited by 4 publications

(8 citation statements)

References 111 publications

(142 reference statements)

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“…The complex structure of articular cartilage needs to be understood prior to the development of a mimicking construct. The articular cartilage has the main responsibility of transmitting the loads to the related subchondral bone, then absorbing the impact forces, leading to the enhancement of a smooth, low-friction, and sliding motion of that joint [16]. When a cartilage is subjected to a persistent load, these functions compromise its rheological viscoelastic properties.…”

Section: Articular Cartilagementioning

confidence: 99%

“…Particulate nanomaterials can also be combined with biomaterials which can stimulate the native cartilage's extracellular microenvironment. This in turn increases the cells interaction with the fabricated scaffold to progress the utility of the subsequent engineered construct [16]. Nanoscale features are believed to affect the cell behavior to a great extent, resulting in alterations in the cell shape, cytoskeleton, motility, and focal adhesions along with the expression of different genes [16].…”

Section: Introductionmentioning

confidence: 99%

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The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

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The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.

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Section: Articular Cartilagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

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“…Research in TMJ disc tissue engineering has explored methods based on scaffolds, cell sources, and biological/biomechanical stimuli [44,47]. Potential applications for TMJ disc regeneration include the incorporation of nanomaterial scaffolds (nanosurfaces, nanofibers, and nanocomposites) used for cartilage tissue engineering [48][49][50].…”

Section: Cartilage Tissue Regeneration (Temporomandibular Joint)mentioning

confidence: 99%

“…Nanosurface-type scaffolds have geometrically defined nanopatterns on their surfaces [50]. Balasundaram et al modified polyurethane and PCL surfaces by casting these surfaces over a spiky titanium surface, which resulted in an increase of chondrocyte numbers, intracellular chondrocyte protein production, and chondrocyte collagen secretion [51].…”

Section: Cartilage Tissue Regeneration (Temporomandibular Joint)mentioning

confidence: 99%

“…In areas of increased insulin and β-glycerophosphate, they found that chondrogenic differentiation and mineralization increased, respectively [54]. Nanofibrous scaffolds were also made from poly(β-caprolactone)-block-poly(L-lactide) copolymers and were found to increase collagen type II expression in chondrocytes [50]. Electrospun PLA nanofibers with surface carboxylate groups were created by Chen and Su and were found to enhance the viability, proliferation, and differentiation of rabbit articular chondrocytes [55].…”

Section: Cartilage Tissue Regeneration (Temporomandibular Joint)mentioning

confidence: 99%

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Nanomaterials in Craniofacial Tissue Regeneration: A Review

Tao

Pham

et al. 2019

Applied Sciences

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Nanotechnology is an exciting and innovative field when combined with tissue engineering, as it offers greater versatility in scaffold design for promoting cell adhesion, proliferation, and differentiation. The use of nanomaterials in craniofacial tissue regeneration is a newly developing field that holds great potential for treating craniofacial defects. This review presents an overview of the nanomaterials used for craniofacial tissue regeneration as well as their clinical applications for periodontal, vascular (endodontics), cartilage (temporomandibular joint), and bone tissue regeneration (dental implants and mandibular defects). To enhance periodontal tissue regeneration, nanohydroxyapatite was used in conjunction with other scaffold materials, such as polylactic acid, poly (lactic-co-glycolic acid), polyamide, chitosan, and polycaprolactone. To facilitate pulp regeneration along with the revascularization of the periapical tissue, polymeric nanofibers were used to simulate extracellular matrix formation. For temporomandibular joint (cartilage) engineering, nanofibrous-type and nanocomposite-based scaffolds improved tissue growth, cell differentiation, adhesion, and synthesis of cartilaginous extracellular matrix. To enhance bone regeneration for dental implants and mandibular bone defects, nanomaterials such as nanohydroxyapatite composite scaffolds, nanomodified mineral trioxide aggregate, and graphene were tested. Although the scientific knowledge in nanomaterials is rapidly advancing, there remain many unexplored data regarding their standardization, safety, and interactions with the nanoenvironment.

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The advances in nanomedicine for bone and cartilage repair

Qiao

Tang

et al. 2022

J Nanobiotechnol

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With the gradual demographic shift toward an aging and obese society, an increasing number of patients are suffering from bone and cartilage injuries. However, conventional therapies are hindered by the defects of materials, failing to adequately stimulate the necessary cellular response to promote sufficient cartilage regeneration, bone remodeling and osseointegration. In recent years, the rapid development of nanomedicine has initiated a revolution in orthopedics, especially in tissue engineering and regenerative medicine, due to their capacity to effectively stimulate cellular responses on a nanoscale with enhanced drug loading efficiency, targeted capability, increased mechanical properties and improved uptake rate, resulting in an improved therapeutic effect. Therefore, a comprehensive review of advancements in nanomedicine for bone and cartilage diseases is timely and beneficial. This review firstly summarized the wide range of existing nanotechnology applications in the medical field. The progressive development of nano delivery systems in nanomedicine, including nanoparticles and biomimetic techniques, which are lacking in the current literature, is further described. More importantly, we also highlighted the research advancements of nanomedicine in bone and cartilage repair using the latest preclinical and clinical examples, and further discussed the research directions of nano-therapies in future clinical practice. Graphical Abstract

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Nanomaterials for cartilage tissue engineering

Cited by 4 publications

References 111 publications

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Nanomaterials in Craniofacial Tissue Regeneration: A Review

The advances in nanomedicine for bone and cartilage repair

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