Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA

Abstract

ANCA (anti-neutrophil cytoplasmic antibody) vasculitides are systemic autoimmune diseases in which anti-neutrophilic cytoplasmic antibodies activate primed neutrophils, thereby generating an inflammatory cascade resulting in the damage of small sized blood vessels in various organs of the body, including the heart. Pleuropericardial involvement is underrecognized as a complication of ANCA vasculitis and is highlighted in this case report of a 51-year-old male who presented with an initial symptomatic presentation of pleuropericardial effusion progressing to pericardial tamponade in the setting of a later renal biopsy proven pauci-immune crescentic glomerulonephritis with high ANA titres along with positive cANCA (cytoplasmic ANCA) and PR3 (proteinase 3) antibodies. He was found to have acute renal failure which progressively got better with cyclophosphamide.

Corrigendum to “Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA”

“…In the article titled “Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA” [1], there were some errors as follows.There was an error in the “Case Presentation” Section, where “5 mg of motrin” should be corrected to “5 tabs of Motrin at a time.”There was an error in the “Abstract,” where the sentence “a 51-year-old male who presented with an initial symptomatic presentation of pleuropericardial effusion progressing to pericardial tamponade in the setting of a later renal biopsy proven pauci-immune crescentic glomerulonephritis with high ANA titres along with positive cANCA (cytoplasmic ANCA) and PR3 (proteinase 3) antibodies” should be corrected as follows: “a 51-year-old male who had an initial symptomatic presentation of pleuropericardial effusion that later progressed to pericardial tamponade in the setting of a renal biopsy proven pauci-immune crescentic glomerulonephritis. This patient also had high ANA titers along with positive cANCA (cytoplasmic ANCA) and PR3 (proteinase 3) antibodies.”There was an error in the “Discussion” Section, where the sentence “In this case report, the patient presented with an initial predominant presentation of pericardial tamponade and was then discovered to have renal biopsy proven PR3 pauci-immune glomerulonephritis” should be corrected as follows.“In this case report, the patient presented with an initial predominant clinical scenario of pericardial tamponade and was then discovered to have renal biopsy-proven PR3 pauci-immune glomerulonephritis.”…”