Corrigendum to “Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA”

Vanga, Amaresh; Rana, Amna; Kowalewska, Jolanta; Rust, Harlan

doi:10.1155/2019/6703652

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Yang et al [20] reported that the positive rate of ANA in ANCA-positive IgAN patients was significantly higher than that in ANCA-negative IgAN patients, which was consistent with the results of this paper. Some cases suggest that when both ANA and ANCA are positive in AAV, there may be more severe clinical and histological manifestations [16,[43][44][45][46]. For example, Zhao et al [43] found that damage was more severe, histopathological changes were more chronic, and the possibility of reaching ESRD was higher in ANA-positive AAV patients renal than in those who were ANA-negative, suggesting that ANA was of great significance to the prognosis of AAV patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features and Outcomes of IgA Nephropathy with Serum Antineutrophil Cytoplasmic Autoantibody Positivity

Li,

Chen,

Chen

et al. 2023

Am J Nephrol

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Objective: IgA nephropathy (IgAN) with serum Antineutrophil Cytoplasmic Autoantibody (ANCA) positivity is uncommon. This study analyzed the clinicopathologic features and prognosis of IgAN patients with serum ANCA positivity. Methods: 2864 IgAN patients were tested for ANCA by the indirect immunofluorescence assay and chemiluminescence immunoassay. Patients with serum ANCA positivity (n=85) were identified and their clinical, pathological and prognostic characteristics were analyzed. They were compared with ANCA negative IgAN patients (n=170) and ANCA-associated systemic vasculitis (AAV) with renal involvement patients (n=85) selected randomly. Result：2.97% (85/2864) of IgAN were ANCA positive and 4 patients were diagnosed as crescentic IgAN with ANCA positivity. The clinicopathological characteristics of ANCA-positive IgAN patients were comparable to ANCA-negative IgAN patients, but they had higher antinuclear antibodies (ANA) positive rates and lower levels of renal interstitial inflammation and less immune depositions than ANCA-negative IgAN patients. Compared with AAV patients, ANCA-positive IgAN patients were younger, fewer extrarenal manifestations, milder renal damage and more immune complexes depositions. The renal outcomes were similar between IgAN patients with and without ANCA positivity. Multivariate Cox analysis revealed that in IgAN patients with ANCA positivity, male, ANA positivity, higher serum creatinine and proteinuria, and more severe renal tubular atrophy/interstitial fibrosis were risk factors for adverse renal outcomes. Conclusion: The clinical, pathological features and prognosis of ANCA-positive IgAN patients were similar with ANCA-negative IgAN patients except for higher ANA positive rate, milder renal inflammation and less immune depositions. ANA positivity was an independent risk factor for adverse renal outcomes in ANCA-positive IgAN patients.

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