Pericapillary Spongy Sheaths in the Human Spleen

Brozman, M

doi:10.1159/000145818

Cited by 5 publications

(3 citation statements)

References 9 publications

(12 reference statements)

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“…As shown in our previous studies [Brozman et al, 1983;Brozman, 1984], anticartilaginous antisera vis ualized different extracellular structures, yet most dis tinctly. pericapillary spongy sheaths in the red pulp and the MZ, as well as periarterial and follicular circumfe rential reticulum in the white pulp.…”

Section: Resultsmentioning

confidence: 52%

Anatomical Pathways from the White to the Red Pulp in the Human Spleen

Brozman¹

1985

Cells Tissues Organs

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In the human spleen we failed to find marginal zone bridging channels which in rats and mice are said to serve as return routes for lymphocytes from the white into the red pulp. In human spleens, using anticartilaginous antisera which distinctly visualized extracellular structures, in some parts we found the periarterial lymphocyte sheath to be closely attached to the red pulp, so that lymphocytes and other material could pass from the white pulp directly into the red pulp and vice versa. The strips of reticular fibres that seemed to bridge the marginal zone between the follicles and the red pulp proved to be components of reticular structures around the arteries, passing from the periarterial lympohcyte sheath into the follicles or from the follicles through the marginal zone into the red pulp.

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Section: Resultsmentioning

confidence: 52%

Anatomical Pathways from the White to the Red Pulp in the Human Spleen

Brozman¹

1985

Cells Tissues Organs

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“…Brozman (1984) reported that the number of ellipsoids generally decreases in older subjects, whereas Buyssens et al (1984) found no change with age. Because of variability in the degree of filling, inherent in our casting technique, we were not able to make quantitative comparisons of the number of ellipsoids in the different spleens (from subjects 2 to 62 years of age), but qualitative observations of the casts lead us to conclude that the number of ellipsoids decreases with age.…”

Section: Flow Through Ellipsoid Sheathsmentioning

confidence: 96%

“…Ellipsoids in human spleen have been investigated by histological (Herrlinger, 1949;Snook, 1950;Van Krieken et al, 1985a) and enzyme cytochemical studies (Brozman, 1984;Buyssens et al, 19841, and the following features are relevant to the present discussion. Ellipsoids are found in both the MZ and the red pulp and are often in close contact with venous sinuses; multiple branching of capillaries may occur within the ellipsoids; and the reticulum of the ellipsoid sheath is more finely meshed than that of the red D u b All these features are confirmed bv our casts.…”

Section: Flow Through Ellipsoid Sheathsmentioning

confidence: 99%

Microcirculatory pathways in normal human spleen, demonstrated by scanning electron microscopy of corrosion casts

1988

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Confusion regarding microcirculatory pathways in normal human spleen has arisen due to extrapolation from pathological material and from other mammalian spleens, not to mention difficulties in tracing intricate three-dimensional routes from the study of thin sections or cut surfaces of tissue. We examined microcirculatory pathways in normal human spleens freshly obtained from organ transplant donors. A modified corrosion casting procedure was used to obtain an open view of vessels and their connections. Our results demonstrate: 1) "arteriolar-capillary bundles" within lymphatic nodules and extensive branching of arterioles in the marginal zone (MZ); 2) the marginal sinus around lymphatic nodules; 3) the peri-marginal cavernous sinus (PMCS) outside the MZ or immediately adjacent to the nodule itself; the PMCS receives flow via ellipsoid sheaths and MZ, or directly from arterial capillaries, and drains into venous sinuses; 4) fast pathways for flow into venous sinuses via ellipsoid sheaths; 5) arterial capillary terminations in the reticular meshwork of the red pulp or MZ ("open" circulation); direct connections to venous sinuses also occur ("closed" circulation), although rarely; and 6) numerous open-ended venous sinuses in the MZ, allowing a large proportion of the splenic inflow to bypass the red cell filtration sites in the reticular meshwork and at venous sinus walls.

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Outer mantle zone of the follicle in the human spleen

Brozman

1985

Vichows Archiv A Pathol Anat

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The follicular circumferential connective fibre reticulum, which is a continuation of the circumferencial reticulum (CR) of the periarterial lymphocyte sheaths, was visualized at the periphery of lymphoid follicles in the human spleen by means of anticartilaginous antiserum. If this CR is considered to be the borderline between the follicular and extrafollicular structures, then at the inner aspect of the CR and at the periphery of the fully developed follicle two mantle zones can be distinguished: an inner zone consisting of small lymphocytes, and an outer consisting of medium-sized lymphocytes. Both all groups are B-lymphocytes displaying positive surface IgM. The reticulum is the same in both mantle zones and it is completely different from the reticulum of the marginal zone. In some instances it is so sparse as to appear to be absent completely. The newly delimitated outer mantle zone also has a specific cellular composition differing from the marginal zone. Most importantly, it does not possess that mixture of lymphocytes and other blood cells which is considered to be the defining feature of the marginal zone. The characteristic cellular components of the outer mantle zone are the densely accumulated medium-sized lymphocytes, with other cells interspersed very sporadically.

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Pericapillary Spongy Sheaths in the Human Spleen

Cited by 5 publications

References 9 publications

Anatomical Pathways from the White to the Red Pulp in the Human Spleen

Anatomical Pathways from the White to the Red Pulp in the Human Spleen

Microcirculatory pathways in normal human spleen, demonstrated by scanning electron microscopy of corrosion casts

Outer mantle zone of the follicle in the human spleen

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