Perianal Basal Cell Carcinoma

Abstract

The tumor should be histologically distinguished from basaloid carcinoma of the anus, which is much more aggressive and metastasizes early, thus requiring a different therapy.

Giant Perianal Basal Cell Carcinoma: An Uncommon Localization: Case Report

“…Damin et al reported that 30% of patients with perianal BCC also had BCC of other body regions. 5 No other lesions were found in the presented patient.…”

“…Developing in regions that are not exposed to sunlight, such as perianal and genital regions, suggests etiologic factors other than ultraviolet light. 1,2,4,5 Although histopathologic findings of the BCC developing in the perianal region are similar to those of BCC seen in other regions, perianal ones behave much more aggressively. Early diagnosis is life saving because of BCC in this localization is prone to metastasize early in the course of the disease, and tends to be fatal.…”

“…9 Perianal BCC cases have also been reported in patients receiving pelvic radiotherapy due to genitourinary system malignancies. 1,2,5 In a study performed by Eliezri et al, HPV DNA type 16 infection has been shown in biopsy specimens of BCCs developed in sun exposed areas, such as head and neck. 10 In another study that investigated the role of HPV in the etiology of BCC, no relationship was found.…”

“…3,5 Although male predominance is suggested in some series, other reports indicate that this predominance is still debatable. 6 BCC peaks at 6 th decade.…”

“…Although classical BCCs rarely metastasize, metastases to the subclavian lymph node have been reported in 2 cases of perianal and vulvar BCC. 1,5 The main causative factor in the pathogenesis of BCC is exposure to ultraviolet light. However, etiologic factors of BCCs in areas not exposed to sun have not yet been fully understood.…”