Periampullary and duodenal carcinoid tumours

Warren, Kenneth W.; McDonald, William M.; Logan, C. J. H.

doi:10.1136/gut.5.5.448

Cited by 27 publications

(11 citation statements)

References 13 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with tumours in other duodenal sites, even small (<1 cm) ampullary and periampullary carcinoid tumours exhibit distinctly different aggressive behaviour, and may metastasise early 12 13. Radical surgical treatment of pancreaticoduodenal resection is favoured 14. Our patient underwent Whipple's pancreaticoduodenectomy and regional lymphadenectomy.…”

Section: Discussionmentioning

confidence: 87%

Duodenal carcinoid with carcinoid syndrome

et al. 2014

View full text Add to dashboard Cite

Carcinoid tumours are uncommon well-differentiated neuroendocrine tumours. Primary duodenal carcinoids account for less than 2% of all gastrointestinal carcinoids. Duodenal carcinoids are seldom associated with carcinoid syndrome. We report a rare case of duodenal carcinoid presenting as a carcinoid syndrome in a middle-aged man with upper abdominal pain, hot flushes, diarrhoea and dry cough. Endoscopy-guided biopsy and 24 h urine 5-hydroxyindoleacetic acid (5-HIAA) proved the diagnosis. He was further evaluated and managed with definitive surgical treatment.

show abstract

Section: Discussionmentioning

confidence: 87%

Duodenal carcinoid with carcinoid syndrome

et al. 2014

View full text Add to dashboard Cite

show abstract

“…1,2 To date, only approximately 100 ampullary carcinoids have been described, most in singlecase reports. 3 Ampullary carcinoid tumors belong to the neuroendocrine tumor family and can cause symptoms usually secondary to their periampullary location.…”

Section: Introductionmentioning

confidence: 99%

Radical Surgical Resection for Carcinoid Tumors of the Ampulla

Hwang

Lee

et al. 2008

Journal of Gastrointestinal Surgery

View full text Add to dashboard Cite

Ampullary carcinoid tumors are extremely rare. The present study describes the clinicopathological features and outcomes for 10 ampullary carcinoid patients who underwent radical resection from 1998 to 2005. During this study period, 294 patients underwent pancreatoduodenectomy for ampullary neoplasms in our institution. The mean patient age was 58.0 +/- 13.4 years, and seven were male. Initial clinical manifestations were jaundice in four patients, nonspecific gastrointestinal symptoms in five, and completely asymptomatic in one. Standard pancreatoduodenectomy was performed in three patients, and pylorus-preserving pancreatoduodenectomy in seven, and there were no major complications. The mean tumor size and volume were 2.1 +/- 1.3 cm and 4.1 +/- 6.9 ml, respectively. Synaptophysin staining was positive in ten patients and chromogranin staining positive in eight. R0 resection was achieved in all ten patients. Overall and disease-free survival rates were 90 and 80% at 1 year, and 64 and 56% at 3 years, respectively. The liver was the most common site of initial metastasis after curative resection. Univariate analyses revealed that a maximal tumor diameter > or =2 cm and tumor extension beyond the ampulla were risk factors for tumor recurrence. In conclusion, while the majority of ampullary carcinoids are indolent, this tumor is associated with a relatively poor prognosis. We believe that radical resection, with the aim of complete tumor removal and cure, is the treatment of choice.

show abstract

“…Several authors have reported a higher incidence of peptic ulcer disease associated with carcinoid tumor than is found in the normal population [2, 5, 101. Erosion of a carcinoid tumor producing hemorrhage is a rare occurrence according to Warren et al [5]. The gastrointestinal hemorrhages in cases 2 and 6 were seen to be due to erosion and ulceration of tumor mass.…”

Section: Discussionmentioning

confidence: 99%

“…The gastrointestinal hemorrhages in cases 2 and 6 were seen to be due to erosion and ulceration of tumor mass. Warren et al [5] describe a maximal incidence of carcinoid in the first portion of the duodenum (57%), a less frequent incidence in the ampullary region (23%), and a low incidence in the third portion of the duodenum (3%). The roentgenographic findings are nonspecific as mentioned above, but the demonstration of a duodenal The most useful laboratory test is an examination for 5-hydroxyindolacetic acid in the urine.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Carcinoid of the duodenum: A report of six cases

Clements

Roche

1984

Gastrointest Radiol

View full text Add to dashboard Cite

Duodenal carcinoid tumors are rare. Six cases of primary duodenal carcinoid tumors are presented. Analysis of these cases indicates that the radiographic appearance can vary from a benign-appearing intramural submucosal mass lesion to a large bulky ulcerating lesion. All cases in this series followed a benign course. One patient has survived over 30 years with proven regional and hepatic metastases. This patient showed regression of the duodenal lesion following embolization for control of severe hemorrhage.

show abstract

Periampullary and duodenal carcinoid tumours

Cited by 27 publications

References 13 publications

Duodenal carcinoid with carcinoid syndrome

Duodenal carcinoid with carcinoid syndrome

Radical Surgical Resection for Carcinoid Tumors of the Ampulla

Carcinoid of the duodenum: A report of six cases

Contact Info

Product

Resources

About