Periadventitial tissue examination in temporal artery biopsies for suspected giant cell arteritis: a case series and literature review

McDonald, Heather M.; Farmer, James; Blanco, Paula

doi:10.1016/j.jcjo.2018.12.011

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Although the perivascular layer has been poorly studied in GCA, it may be involved in the inflammation of the adjacent artery like it has been shown in other vascular diseases ( 28 , 29 ). A previous study has suggested the involvement of the periadventitial tissue in a subgroup of GCA ( 30 ), however, in our study, all the GCA patients did not exhibit the histological pattern they described.…”

Section: Discussioncontrasting

confidence: 89%

Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis

Parreau,

Molina,

Dumonteil

et al. 2023

Front. Immunol.

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ObjectiveTo identify the key coding genes underlying the biomarkers and pathways associated with giant cell arteritis (GCA), we performed an in situ spatial profiling of molecules involved in the temporal arteries of GCA patients and controls. Furthermore, we performed pharmacogenomic network analysis to identify potential treatment targets.MethodsUsing human formalin-fixed paraffin-embedded temporal artery biopsy samples (GCA, n = 9; controls, n = 7), we performed a whole transcriptome analysis using the NanoString GeoMx Digital Spatial Profiler. In total, 59 regions of interest were selected in the intima, media, adventitia, and perivascular adipose tissue (PVAT). Differentially expressed genes (DEGs) (fold-change > 2 or < −2, p-adjusted < 0.01) were compared across each layer to build a spatial and pharmacogenomic network and to explore the pathophysiological mechanisms of GCA.ResultsMost of the transcriptome (12,076 genes) was upregulated in GCA arteries, compared to control arteries. Among the screened genes, 282, 227, 40, and 5 DEGs were identified in the intima, media, adventitia, and PVAT, respectively. Genes involved in the immune process and vascular remodeling were upregulated within GCA temporal arteries but differed across the arterial layers. The immune-related functions and vascular remodeling were limited to the intima and media.ConclusionThis study is the first to perform an in situ spatial profiling characterization of the molecules involved in GCA. The pharmacogenomic network analysis identified potential target genes for approved and novel immunotherapies.

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Section: Discussioncontrasting

confidence: 89%

Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis

Parreau,

Molina,

Dumonteil

et al. 2023

Front. Immunol.

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“…Other less frequent inflammatory patterns in GCA include vasa vasorum vasculitis, in which inflammation is limited to the adventitial vasa vasorum without extension to the media. 19 , 20 …”

Section: Diagnosismentioning

confidence: 99%

Giant Cell Arteritis: State of the Art in Diagnosis, Monitoring, and Treatment

Awisat¹,

Keret²,

Silawy³

et al. 2023

Rambam Maimonides Med J

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Giant cell arteritis (GCA) is the most prevalent subtype of vasculitis in adults. In recent years, there has been substantial improvement in the diagnosis and treatment of GCA, mainly attributed to the introduction of highly sensitive diagnostic tools, incorporation of modern imaging modalities for diagnosis and monitoring of large-vessel vasculitis, and introduction of highly effective novel biological therapies that have revolutionized the field of GCA. This article reviews state-of-the-art approaches for the diagnosis, monitoring, and treatment options of GCA.

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“…Key papers relating to parameters of interest were collated and sent to the study participants for review before starting the Delphi process to standardise knowledge and maximise the efficiency of discussions. [11][12][13][14][15][16] Figure 1 provides example whole slide images (WSI) hosted by the Leeds Virtual Pathology website 17 (refer to online supplemental content).…”

Section: Statement Formulation Processmentioning

confidence: 99%

Histopathology reporting of temporal artery biopsy specimens for giant cell arteritis: results of a modified Delphi study

et al. 2023

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The temporal artery biopsy (TAB) is regarded as the gold-standard test in the diagnosis of giant cell arteritis (GCA). There is a lack of agreement among experienced pathologists regarding the diagnostic features and classification of inflammation observed in TAB sections in the diagnosis of GCA.AimsThe aim of this research study was to establish consensus on the key parameters which should be included in a standardised reporting proforma for TAB specimens. We specifically investigated factors pertaining to clinical information, specimen handling and microscopic pathological features.MethodsA modified Delphi process, comprising three survey rounds and three virtual consensus group meetings, was undertaken by 13 UK-based pathology or ophthalmology consultants, with a 100% response rate across the three rounds. Initial statements were formulated after a literature review and participants were asked to rate their agreement using a nine-point Likert scale. Consensus was defined a priori as an agreement of ≥70% and individual feedback was provided after each round, together with data on the distribution of group responses.ResultsOverall, 67 statements reached consensus and 17 statements did not. The participants agreed on the core microscopic features to be included in a pathology report and felt that a proforma would facilitate consistent reporting practices.ConclusionsOur work revealed uncertainty surrounding the correlation between clinical parameters (eg, laboratory markers of inflammation and steroid therapy duration) and microscopic findings, and we propose areas for future research.

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Periadventitial tissue examination in temporal artery biopsies for suspected giant cell arteritis: a case series and literature review

Cited by 8 publications

References 29 publications

Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis

Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis

Giant Cell Arteritis: State of the Art in Diagnosis, Monitoring, and Treatment

Histopathology reporting of temporal artery biopsy specimens for giant cell arteritis: results of a modified Delphi study

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