Pleomorphic xanthoastrocytomas (PXA) with malignant transformation are reported in two adult men with a long history of seizures, recent onset of neurological symptoms and superficially located, temporal lobe lesions. Although PXA is generally described as having relatively benign behaviour, this report adds two further cases of malignant transformation to the literature.
then the possibility of aberrant lacrimal gland with fistula needs to be considered among other rare causes. The use of probing can demonstrate the presence of a fistula, which usually fills with dye on retrograde injection. The mass of the aberrant gland may be too small to show up on a radioisotope uptake study, as happened in our case. Surgical excision of the offending aberrant gland and fistula is the treatment of choice.
In the absence of a recognizable source of metastasis, a diagnosis of primary ocular adenocarcinoma has been made with retinal pigment epithelium being the possible site of origin. Literature review shows that primary ocular adenocarcinoma arising from neuroepithelium is a rare but recognized occurrence especially in longstanding blind eyes. This case highlights the importance of routine histopathological examination of eviscerated ocular contents, especially in long standing blind eyes.
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