Peri-papillary retinal nerve fiber layer thickness profile in subjects with myopia measured using optical coherence tomography

Kamath, Ajay R; Dudeja, Lakshey

doi:10.4103/2320-3897.138853

Cited by 10 publications

(11 citation statements)

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“…Similarly, Leung et al 8 using Stratus OCT found average RNFL thickness and thickness in 12, 1, and 7 o’clock less in high myopes (SE < -6 D) as compared to low to moderate myopes (SE between -6 D and -0.5 D). Kamath and Dudeja, 9 Wang et al, 10 and Kang et al 11 used SD-OCT and found average RNFL thickness and thickness in superior and inferior quadrant to be significantly less in myopes similar to our study. However, contrary results were seen in various studies on comparing RNFL thickness in nasal and temporal quadrant.…”

Section: Discussionsupporting

confidence: 89%

“…In our study, RNFL thickness in nasal quadrant was significantly less in moderate and high myopes when compared with emmetropes, whereas increased RNFL thickness was seen in temporal quadrant in high myopes. Kamath and Dudeja, 9 found significant decrease in RNFL thickness in nasal quadrant and insignificant decrease in temporal quadrant in high myopes whereas Wang et al 10 and Kang et al 11 in their study found insignificant change in nasal quadrant and thickening in temporal quadrant. Oner et al, 12 used RTVue SD-OCT found significant decrease in RNFL thickness in all quadrants except nasal quadrant.…”

Section: Discussionmentioning

confidence: 79%

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Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia

Singh

Agarwal

Sharma

et al. 2017

Journal of Current Glaucoma Practice

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Introduction To evaluate the relationship between retinal nerve fiber layer (RNFL) thickness measured by Cirrus high-definition (HD) optical coherence tomography (OCT) and the axial length and refractive error of the eye.Materials and methods A total of 100 eyes of 100 healthy subjects (age 20-34 years with M/F ratio of 57/43), comprising 50 eyes with emmetropia [spherical equivalent (SE) 0 D], 25 eyes with moderate myopia (SE between -4 D and -8 D), and 25 eyes with high myopia (SE between -8 D and -12 D) were analyzed in this cross-sectional study. Average and mean clock hour RNFL thicknesses were measured by cirrus HD-OCT and compared between the three groups. Associations between RNFL measurements and axial length and SE were evaluated by linear regression analysis.Results The average RNFL measurements were significantly lower in high myopia (78.68 +/- 5.67) and moderate myopia (83.76 +/- 3.44) group compared with emmetropia group (91.26 +/- 2.99), also in the superior and inferior mean clock hours. Significant correlations were evident between RNFL measurements and the SE and axial length. The average RNFL thickness decreased with increasing axial length (r = -0.8115) and negative refractive power (r = 0.8397). Myopia also affected the RNFL thickness distribution. As the axial length increased and the SE decreased, the thickness of the superior, inferior, and nasal peripapillary RNFL decreased.Conclusion The axial length/refractive error of the eye affected the average RNFL thickness and the RNFL thickness distribution. Analysis of RNFL thickness in the evaluation of glaucoma should always be interpreted with reference to the refractive status. When interpreting the RNFL thickness of highly myopic patients by OCT, careful attention must be given to the inherently thinner RNFL to avoid a false diagnosis of glaucoma.How to cite this article Singh D, Mishra SK, Agarwal E, Sharma R, Bhartiya S, Dada T. Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia. J Curr Glaucoma Pract 2017;11(2):52-57.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 79%

Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia

Singh

Agarwal

Sharma

et al. 2017

Journal of Current Glaucoma Practice

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“…In a study conducted by Kamath et al in 118 myopes, the average RNFL thickness was lower in the high myopia group (80.45 ± 10.1 μm) than in the low (94.9 ± 7.8 μm) and moderate myopia groups (87.1 ± 10.8 μm). 10 In a similar study from China by Zha et al on 271 subjects, the average RNFL thickness was lower in high myopia group (90.57 ± 10.07 μm) than in low (101.46 ± 7.95 μm) and moderate myopia group (99.15 ± 8.94 μm). 11 The average RNFL thickness in all three groups in these studies were less than ours, but the differences between the three were similar.…”

Section: Discussionmentioning

confidence: 77%

“…However, temporal quadrant showed thinning in low myopia group than in moderate and high myopia groups (p < 0.98). 10 In another study done by Kim et al, the RNFL thickness was found to be more in the superior, inferior and nasal quadrant (p = 0.020, p < 0.001 and p < 0.001 respectively) in the low myopia group when compared to the moderate and high myopia groups. The RNFL thickness in the temporal quadrant was more in the moderate and high myopia groups as compared to the low myopia group (p = 0.001).…”

Section: Discussionmentioning

confidence: 85%

Retinal Nerve Fiber Layer Measurements in Myopes as Determined by Optical Coherence Tomography

M¹,

Chopra²,

Batra³

2019

jebmh

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BACKGROUND Myopia is a common cause of visual disability throughout the world. One of the potentially blinding ocular diseases associated with myopia is glaucoma. Due to similar features of the optic disc in glaucoma and myopia, there may be a misdiagnosis of glaucoma in these individuals. Decrease in retinal nerve fiber layer (RNFL) thickness as measured by optical coherence tomography (OCT) is a sensitive indicator of early glaucomatous damage. However, it remains unclear if RNFL thickness varies with refractive status of the eye. We wanted to compare retinal nerve fiber layer thickness in low, moderate and high myopia patients and study the association between retinal nerve fiber layer thickness, axial length and myopic spherical equivalent. METHODS A total of 150 eyes of 150 subjects with varying degree of myopia presenting to the Department of Ophthalmology, Christian Medical College and Hospital, Ludhiana were included in the study group. Comprehensive ophthalmic examination was performed which included visual acuity, refraction by autorefractometer, axial length by NIDEK AL-SCAN and retinal nerve fiber layer thickness by optical coherence tomography (NIDEK RS 3000 LITE). RESULTS The average (360°) RNFL thickness was significantly lower in the high myopia group as compared to the low and moderate myopia groups (p < 0.0001). On quadrant wise analysis, the RNFL was thicker in the low myopia group than in the moderate and high myopia groups in the superior, nasal and inferior quadrants (p < 0.0001, p<0.0001 and p-0.0002 respectively). However, the RNFL thickness in the temporal quadrant was comparable in the three groups (p = 0.768). CONCLUSIONS Retinal nerve fiber layer thickness decreases as the spherical equivalent and axial length increases. Therefore, this profile should be taken into consideration while analysing RNFL thickness for glaucoma evaluation in subjects with highly myopia.

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“…In our study average RNFL thickness was 85.40±15.45 µ in high myopia group which is comparable to RNFL thickness of moderate myopia group in Kamath et al study, but thicker as compared to high myopia group. 6…”

Section: Discussionmentioning

confidence: 99%

Comparison of Retinal Nerve Fiber Layer Thickness Between Emmetropes and High Myopes

Yadav¹

2019

IJMBS

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Background: The present study aims to compare RNFL thickness of high myopes of > - 6D and compare with emmetropic patients, so as to interpret and distinguish the physiological changes of high myopia from accompanying diseases in such individuals. Methods: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction and visual field analysis. Optical coherence tomography was used for RFNL thickness measurement. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance. Results: The mean value of average RNFL thickness in both groups was found to be 85.40 in group 1 and 99.34 in group 2. P value was 0.0001, showing that there was significant statistical difference between both the groups and average RNFL thickness was thinner in myopic group. Conclusion: RNFL was found to be significantly thin in high myopia. Keywords: RNFL thickness, Myopia, Emmetropes

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Peri-papillary retinal nerve fiber layer thickness profile in subjects with myopia measured using optical coherence tomography

Cited by 10 publications

References 0 publications

Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia

Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia

Retinal Nerve Fiber Layer Measurements in Myopes as Determined by Optical Coherence Tomography

Comparison of Retinal Nerve Fiber Layer Thickness Between Emmetropes and High Myopes

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