Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia

Singh, Digvijay; Agarwal, Esha; Sharma, Reetika; Bhartiya, Shibal; Dada, Tanuj

doi:10.5005/jp-journals-10028-1223

Cited by 15 publications

(7 citation statements)

References 18 publications

(27 reference statements)

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“…[ 12 ] However, for most myopic patients without POAG, numerous studies have reported that the RNFL was also abnormally thin due to axial extension and atrophy of the retina. [ 2 5 6 ] In our study, a thinner RNFL was found in all myopic groups, especially for the moderate- and high-myopic groups. In the high-myopic group, the thinning included almost all the observational parameters.…”

Section: Discussionsupporting

confidence: 56%

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Effectiveness of Glaucoma Diagnostic Parameters from Spectral Domain-Optical Coherence Tomography of Myopic Patients

Fang

Zhang

Qiao

et al. 2018

Chinese Medical Journal

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Background:Currently, spectral-domain optical coherence tomography (SD-OCT) appears to be a new type of glaucoma diagnostic tool. Thus, this study aimed to evaluate the effectiveness of glaucoma diagnostic parameters from SD-OCT of patients with different severities of myopia.Methods:This was a cross-sectional study. A total of 248 participants (248 eyes) were enrolled, including 51 cases in the early primary open-angle glaucoma group, 79 cases in the control group (0.50 D to −0.50 D, excluding −0.50 D), 47 cases in the low-myopic group (−0.50 to −3.00 D, excluding −3.00 D), 43 cases in the moderate-myopic group (−3.00 to −6.00 D, excluding −6.00 D), and 28 cases in the high-myopic group (≤−6.00 D). All participants were examined using the Humphrey visual field test and SD-OCT. The SD-OCT parameters of the retinal nerve fiber layer (RNFL) and ganglion cell complex were analyzed statistically using the receiver operating characteristic curve and area under the curve (AUC).Results:The AUC showed that the best parameters for the control and low-myopic groups were the inferior and inferior temporal RNFL thicknesses (AUC >0.94), respectively; for the moderate- and high-myopic groups, the best parameter was the temporal low RNFL thickness (AUC, 0.926 and 0.896, respectively). The AUC of the inferior parameters of the moderate-myopic group (0.864) was lower, ranked 15th among all RNFL parameters. When the sensitivity was fixed at 85%, the specificity of the inferior, superior, inferior temporal, and superior temporal quadrants was higher (>80%) in the control and low-myopic groups, while they were lower (20–60%) for the moderate- and high-myopia groups. The green color based on the OCT database was also less for the high-myopic group compared with that of other groups (P < 0.05).Conclusions:Glaucoma diagnostic parameters from SD-OCT were not clinically effective for the moderate- and high-myopic groups. The specificities were low. The moderate- and high-myopic groups require comprehensive analyses for the diagnoses of glaucoma. The SD-OCT database should be improved to better indicate the level of myopia based on the corresponding diopter readings.

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Section: Discussionsupporting

confidence: 56%

“…If the accuracy of the measured results is poor, the percentages of misdiagnoses will increase. [ 5 6 ] In the present study, we used SD-OCT, which is widely used in the early diagnosis of glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Glaucoma Diagnostic Parameters from Spectral Domain-Optical Coherence Tomography of Myopic Patients

Fang

Zhang

Qiao

et al. 2018

Chinese Medical Journal

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“…Therefore, the RNFL thickness is negatively correlated with the AXL. Singh et al and Kang et al found that the mean RNFL thickness decreased by 3.74 μm and 2.2 μm, respectively, for each mm increase in the AXL [ 69 , 70 ] Additionally, this thinning of the RNFL in highly myopic eyes is not uniformly distributed, being greater in the lower quadrant (134.8 ± 17 μm vs. 109.9 ± 15 μm, p > 0.001) in emmetropes vs. high myopes, respectively. It has also been observed that myopic eyes have a significantly greater rate of decline in RNFL during follow-up than controls.…”

Section: Rnfl Thickness Measurement By Octmentioning

confidence: 99%

“…The mean RNFL thickness: 110.9 ± 10 μm vs. 89.8 ± 9 μm in highly myopic patients compared to emmetropic patients ( p < 0.001) [ 69 ].…”

Section: Figurementioning

confidence: 99%

Update on the Utility of Optical Coherence Tomography in the Analysis of the Optic Nerve Head in Highly Myopic Eyes with and without Glaucoma

Kudsieh

Fernández‐Vigo

Flores‐Moreno

et al. 2023

JCM

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Glaucoma diagnosis in highly myopic subjects by optic nerve head (ONH) imaging is challenging as it is difficult to distinguish structural defects related to glaucoma from myopia-related defects in these subjects. Optical coherence tomography (OCT) has evolved to become a routine examination at present, providing key information in the assessment of glaucoma based on the study of the ONH. However, the correct segmentation and interpretation of the ONH data employing OCT is still a challenge in highly myopic patients. High-resolution OCT images can help qualitatively and quantitatively describe the structural characteristics and anatomical changes in highly myopic subjects with and without glaucoma. The ONH and peripapillary area can be analyzed to measure the myopic atrophic-related zone, the existence of intrachoroidal cavitation, staphyloma, and ONH pits by OCT. Similarly, the lamina cribosa observed in the OCT images may reveal anatomical changes that justify visual defects. Several quantitative parameters of the ONH obtained from OCT images were proposed to predict the progression of visual defects in glaucoma subjects. Additionally, OCT images help identify factors that may negatively influence the measurement of the retinal nerve fiber layer (RNFL) and provide better analysis using new parameters, such as Bruch’s Membrane Opening-Minimum Rim Width, which serves as an alternative to RNFL measurements in highly myopic subjects due to its superior diagnostic ability.

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“…It has been found that actual scanning radius in eyes with greater axial length (myopic eyes) could be longer than 1.73 mm due to magnification effect, so using same-sized scan circle for measuring pRNFL in patients with different degrees of myopia might be misleading because the RNFL thickness decreases with increasing distances from the optic disk [26]. Therefore, the pRNFL results of the patients with myopia need to be adjusted according to the axial length (AL).…”

Section: Data Processing Of Prnfl and Pvdmentioning

confidence: 99%

Peripapillary vessel density correlates with visual field mean sensitivity in highly myopic eyes

et al. 2022

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Purpose To identify the global and regional distribution of peripapillary vessel density (pVD) and try to find out the relationships between pVD and the visual field mean sensitivity (VFMS) in healthy myopic eyes. Design Prospective cross-sectional study. Methods Two hundred and twenty-two participants (393 eyes) with myopia (myopic refractive error < − 0.5 diopters) from two clinical centers were recruited in this study and were divided into 4 groups according to the spherical equivalent (SE): Group1:− 0.5D ≥ SE > − 6.00D, Group2: − 6.00D ≥ SE > − 8.00D, Group3:− 8.00D ≥ SE > − 10.00D, Group4:SE ≤ -10.00D.The pVD assessed with optical coherence tomography angiography (OCTA) was quantified in 8 sectors. Peripapillary retinal nerve fibre layer (pRNFL) imaging was performed with SD-OCT. Visual field (VF) tests were performed with the 30-2 SITA standard program on the Humphrey 750i Visual Field Analyzer and were grouped into 8 regions that matched the structure. Results The pRNFL had no significant difference in all groups (p = 0.422). The average pVD were significantly lower in group 4 (47.61 ± 6.58) than in group 2 and 3 (51.49 ± 3.21, 50.48 ± 3.43 respectively) (p < 0.05). While both pVD in group2 and 3 were statistically lower than group1 (52.77 ± 2.86). The average VFMS was significantly lower in group 4 (901.85 ± 386.54) than other three groups (1169.15 ± 328.94, 1081.77 ± 338.83, 1076.89 ± 358.18, for group1,2,3 respectively). The pVD and VFMS were positively correlated in group3 (r = 0.184) and group4 (r = 0.476) (p < 0.05). Linear regression analysis demonstrated that VFMS were positively associated with pVD especially in temporal and nasal quadrants in myopic eyes. Conclusions The pVD shows a significant positive correlation with VFMS in highly myopic eyes with SE ≤ − 8.00D. We suggest that pVD measurement by OCTA could be a sensitive and useful method for monitoring myopic functional change.

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Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia

Cited by 15 publications

References 18 publications

Effectiveness of Glaucoma Diagnostic Parameters from Spectral Domain-Optical Coherence Tomography of Myopic Patients

Effectiveness of Glaucoma Diagnostic Parameters from Spectral Domain-Optical Coherence Tomography of Myopic Patients

Update on the Utility of Optical Coherence Tomography in the Analysis of the Optic Nerve Head in Highly Myopic Eyes with and without Glaucoma

Peripapillary vessel density correlates with visual field mean sensitivity in highly myopic eyes

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