Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass

Lagier, David; Nee, Laetitia; Guieu, Régis; Kerbaul, François; Fenouillet, Emmanuel; Roux, Nicolas; Giorgi, Roch; Théron, Alexis; Grisoli, Dominique; Gariboldi, Vlad; Collart, Frédéric; Bruder, Nicolas; Velly, Lionel; Guidon, C.

doi:10.1097/eja.0000000000000824

Cited by 10 publications

(18 citation statements)

References 37 publications

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“…Caffeine intake has been historically limited in peri-operatively in patients due to the risk of vasospasm and risk of cardiac events 55,56 . However, caffeine use after an acute myocardial infarct may be reduce the risk of cardiovascular mortality 57,58 and does not increase risk of atrial brillation after cardiac surgery 37 . At rest, caffeine appears to promote generalised vasodilation and does not affect digital microvascular perfusion 59 60 , however it does result in reduced cerebral blood ow 61,62 .…”

Section: Discussionmentioning

confidence: 99%

Section: Caffeine Use In the Peri-operative Periodmentioning

confidence: 99%

“…There were four studies that investigated the safety and changes associated with caffeine administration [34][35][36][37] . Intra-operative or post-operative caffeine may increase the incidence of post-operative nausea/vomiting 36,37 . Intra-operative caffeine was found not to affect the incidence of post-operative atrial brillation 37 and reduce time to spontaneous voiding post indwelling bladder catheter removal post-operatively 35 .…”

Section: Caffeine Use In the Peri-operative Periodmentioning

confidence: 99%

“…Intra-operative or post-operative caffeine may increase the incidence of post-operative nausea/vomiting 36,37 . Intra-operative caffeine was found not to affect the incidence of post-operative atrial brillation 37 and reduce time to spontaneous voiding post indwelling bladder catheter removal post-operatively 35 . A national survey of 882 nurses found that 85% still practised caffeine restriction in patients after an acute myocardial infarction 34 .…”

Section: Caffeine Use In the Peri-operative Periodmentioning

confidence: 99%

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Use of Therapeutic Caffeine in Acute Care Post-operative and Critical Care Settings: a Scoping Review

Bright¹,

Raman

Laupland

2020

Preprint

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BackgroundCaffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the peri-operative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the intensive care unit (ICU) and post-operative patients. MethodsPubMed, Embase, CINAHL Complete, Scopus and Web of Science were systematically searched for studies investigating the effects of caffeine withdrawal or administration in ICU patients and in the peri-operative period. Areas of recent systematic review such as pain or post-dural puncture headache were not included in this review. Studies were limited to adults. ResultsOf 2268 articles screened, 26 were included and grouped into two themes of caffeine use in in the peri-operative period and in the ICU. Caffeine withdrawal in the post-operative period increases the incidence of headache, which can be effectively treated prophylactically with peri-operative caffeine. There were no studies investigating caffeine withdrawal or effect on sleep wake cycles, daytime somnolence, or delirium in the intensive care setting. Administration of caffeine results in faster emergence from sedation and anaesthesia, particularly in individuals who are at high risk of post-extubation complications. There has only been one study investigating caffeine administration to facilitate post-anaesthetic emergence in ICU. Caffeine administration appears to be safe in moderate doses in the peri-operative period and in the intensive care setting. ConclusionsAlthough caffeine is widely used, there is a paucity of studies investigating withdrawal or therapeutic effects in patients admitted to ICU and further novel studies are a priority.

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Section: Discussionmentioning

confidence: 99%

Section: Caffeine Use In the Peri-operative Periodmentioning

confidence: 99%

Section: Caffeine Use In the Peri-operative Periodmentioning

confidence: 99%

Section: Caffeine Use In the Peri-operative Periodmentioning

confidence: 99%

See 2 more Smart Citations

Use of Therapeutic Caffeine in Acute Care Post-operative and Critical Care Settings: a Scoping Review

Bright¹,

Raman

Laupland

2020

Preprint

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“…In patients undergoing cardiac surgery, perioperative episodes of AF occur in 10 to 50% of cases [ 79 , 80 ]. These episodes are often associated with an increase in adenosine plasma level [ 81 , 82 ].…”

Section: Possible Clinical Consequences Of the Presence Of Spare Receptorsmentioning

confidence: 99%

Adenosine Receptor Reserve and Long-Term Potentiation: Unconventional Adaptive Mechanisms in Cardiovascular Diseases?

Guieu

Brignole

Deharo

et al. 2021

IJMS

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While the concept of a receptor reserve (spare receptors) is old, their presence on human cells as an adaptive mechanism in cardiovascular disease is a new suggestion. The presence of spare receptors is suspected when the activation of a weak fraction of receptors leads to maximal biological effects, in other words, when the half-maximal effective concentration (EC50) for a biological effect (cAMP production, for example) is lower than the affinity (KD) of the ligand for a receptor. Adenosine is an ATP derivative that strongly impacts the cardiovascular system via its four membrane receptors, named A1R, A2AR, A2BR, and A3R, with the A1R being more particularly involved in heart rhythm, while the A2AR controls vasodilation. After a general description of the tools necessary to explore the presence of spare receptors, this review focuses on the consequences of the presence of spare adenosine receptors in cardiovascular physiopathology. Finally, the role of the adenosinergic system in the long-term potentiation and its possible consequences on the physiopathology are also mentioned.

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Caffeine supplementation as part of enhanced recovery after surgery pathways: a narrative review of the evidence and knowledge gaps

Pleticha

Niesen

Kopp

et al. 2021

Can J Anesth/J Can Anesth

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Caffeine is used daily by 85% of United States adults and caffeine withdrawal is a major cause of perioperative headache. Studies have shown that caffeine supplementation in chronic caffeinators reduces the incidence of perioperative headache. This narrative review discusses the perioperative implications of caffeine withdrawal and outlines the benefits of and strategies of caffeine supplementation in the perioperative period. It is time to ''wake up and smell the coffee'' on integration of caffeine into established enhanced recovery after surgery protocols as a mechanism to consistently provide perioperative caffeine replacement.Re ´sume ´La cafe´ine est utilise´e quotidiennement par 85 % des adultes aux E ´tats-Unis, et le sevrage de la cafe´ine constitue une cause majeure de ce´phale´es pe´riope´ratoires. Des e´tudes ont montre´que la supple´mentation en cafe´ine chez les grands buveurs de cafe´re´duisait l'incidence des ce´phale´es pe´riope´ratoires. Ce compte rendu narratif discute des implications pe´riope´ratoires du sevrage de la cafe´ine et de´crit les avantages et les strate´gies de la supple´mentation en cafe´ine en pe´riode pe´riope´ratoire. Il est temps de « se re´veiller a`l'odeur du cafe´» quant al 'inte´gration de la cafe´ine dans les protocoles de re´cupe´ration rapide apre`s la chirurgie en tant que me´canisme pour procurer de fac ¸on syste´matique un subsitut pe´riope´ratoire a`la cafe´ine.

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Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass

Abstract: ClinicalTrials.gov, no.: NCT01999829.

Cited by 10 publications

References 37 publications

Use of Therapeutic Caffeine in Acute Care Post-operative and Critical Care Settings: a Scoping Review

Use of Therapeutic Caffeine in Acute Care Post-operative and Critical Care Settings: a Scoping Review

Adenosine Receptor Reserve and Long-Term Potentiation: Unconventional Adaptive Mechanisms in Cardiovascular Diseases?

Caffeine supplementation as part of enhanced recovery after surgery pathways: a narrative review of the evidence and knowledge gaps

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