Peri‐implant crevicular fluid and serum levels of soluble <scp>ST2</scp> in peri‐implant diseases: A pilot study

Ozgur, Engin; Topçu, Deniz İlhan; Bayraktar, Nilüfer; Alptekin, Nilgün Özlem

doi:10.1111/jre.13082

Cited by 5 publications

(6 citation statements)

References 48 publications

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“…The findings demonstrated that, in comparison to healthy periodontal conditions, the mean sST2 value in the GCF was significantly greater in periodontal disease patients. These outcomes align with previous research (15,28). Numerous inflammatory and immunological diseases, such as pneumonia, rheumatoid arthritis, diabetes, cancer, cardiovascular events, and periodontitis, are related to sST2 levels (15,(29)(30)(31)(32).…”

Section: Discussionsupporting

confidence: 88%

Assessment of gingival crevicular fluid levels of IL33 and sST2 in periodontitis patients with stage I-III disease

Abood,

Mohammed

2024

Immunopathol Persa

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Introduction: Patients with chronic periodontitis exhibit significant interleukin-33 (IL-33) expression in their periodontal tissue. However, it is debatable, whether chronic periodontitis patients with gingival crevicular fluids (GCFs) have increased levels of IL-33. The ligand of the ST2 (suppression of tumorigenity) receptor is IL-33. The Toll-like receptor/IL-1R superfamily includes the ST2 receptor, which exists in two distinct versions; soluble ST2 (sST2), which is secreted, and ST2L, as a transmembrane form. In addition to measuring clinical parameters and correlating them with the levels of IL33 and sST2 in periodontitis patients, the goal of this study was to evaluate the levels of these two biomarkers in the GCF of patients with (stage I, II, and III) periodontitis relative to healthy controls. Objectives: The present study aimed to evaluate the levels of IL33 and sST2 in the GCF of individuals with periodontitis (stages I, II, and III) compared to those in healthy controls, and to assess clinical parameters and compare them to the sST2 and IL33 levels in patients with periodontitis. Materials and Methods: A total of 162 participants participated in the present study. Clinical measurements were made for the probing pocket depth (PPD), plaque index (PI), clinical attachment level (CAL), and bleeding on probing (BOP). The GCF was collected from each patient. To measure IL33 and sST2 levels, enzyme-linked immunosorbent assays (ELISAs) were used. Results: When comparing the periodontitis group to the healthy control group, the levels of IL33 and sST2 were greater (P>0.001). Only in the group with stage II periodontitis was there a significant association between PPD and sST2, whereas no significant correlation was detected between IL33 and periodontal markers. Conclusion: Compared to those of healthy controls, the GCF of periodontitis patients exhibited increased levels of IL33 and sST2. This finding implies that the pathogenesis of periodontitis and periodontal health are both influenced by IL33 and sST2.

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Section: Discussionsupporting

confidence: 88%

Assessment of gingival crevicular fluid levels of IL33 and sST2 in periodontitis patients with stage I-III disease

Abood,

Mohammed

2024

Immunopathol Persa

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“…Finally, a total of 11 articles were eligible for inclusion in the review, among which seven were case–control studies ( 17 – 23 ), and four were cross-sectional studies ( 24 – 27 ) ( Table 1 ; Figure 1 ). Five studies ( 17 , 19 , 22 , 25 , 26 ) compared participants with healthy implants. Another four studies only mentioned that participants from comparison groups were with healthy oral conditions ( 18 , 20 , 21 , 24 ) and did not specify whether dental implants existed or not.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 32 blood parameters were measured to investigate the association between peri-implantitis and systemic inflammation ( Supplementary Table 2 ). After the assessment of available data, one study was not eligible to be included in the meta-analysis due to a lack of standard deviation ( 20 ), and another article presented the data only as medians ( 25 ). Finally, nine articles were included in the quantitative analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies ( 22 , 23 ), which defined peri-implantitis as gingival crevicular bleeding index >1 and periodontal probing depth ≥5 mm, revealed a significantly lower level of CRP in patients without peri-implantitis compared to patients with peri-implantitis ( Table 1 ; Figure 2B , Case definition). Two studies ( 25 , 26 ) defined peri-implantitis following the guidelines of consensus reports of the 2017 World Workshop. No significant difference in CRP levels was discovered between patients with peri-implantitis and without.…”

Section: Resultsmentioning

confidence: 99%

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Association between peri-implantitis and systemic inflammation: a systematic review

Yan,

Orlandi,

Suvan

et al. 2023

Front. Immunol.

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BackgroundPeri-implantitis is an infectious/inflammatory disease with similar clinical and radiographic features to periodontitis. Overwhelming evidence confirmed that periodontitis causes elevations in systemic inflammatory mediators; this is unclear for peri-implantitis. Hence, this study aimed to appraise all available evidence linking peri-implantitis with systemic inflammation.MethodsA systematic review was completed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eight electronic databases (Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Web of Science, Dentistry & Oral Sciences Source, Scopus, LILACS, and China Online), ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP), and gray literature were searched up to February 9, 2023. Human studies of randomized controlled trials, non-randomized intervention studies, cohort studies, case–control, and cross-sectional studies were eligible for inclusion. Quantitative analyses were performed using random effects models.ResultsA total of 27 full-text articles were retrieved, and 11 clinical studies were included in the final analyses. All evidence gathered demonstrated a consistent association between peri-implantitis and systemic inflammation. Patients with peri-implantitis exhibited higher levels of serum C-reactive protein (CRP) (standard mean difference (SMD): 4.68, 98.7% CI: 2.12 to 7.25), interleukin-6 (IL-6) (weighted mean difference (WMD): 6.27 pg/mL, 0% CI: 5.01 to 7.54), and white blood cell counts (WMD: 1.16 * 103/μL, 0% CI: 0.61 to 1.70) when compared to participants without peri-implantitis.ConclusionPeri-implantitis is associated with higher systemic inflammation as assessed by serum CRP, IL-6, and white blood cell counts. Further research is needed to clarify the nature of this association.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=246837, identifier CRD42021246837.

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“…Periodontitis is an infectious‐inflammatory disease of the tooth‐supporting tissues that is mediated by a disrupted immune‐inflammatory response to a pathogenic biofilm (Könönen et al, 2019). Elevated serum levels of sST2 have been associated with periodontitis (Torrungruang et al, 2019), and two pilot studies recently demonstrated increased gingival and peri‐implant crevicular fluid levels of ST2 in periodontitis and peri‐implant diseases, respectively (Navya et al, 2022; Ozgur et al, 2022). However, there is no prior research on salivary sST2 levels of periodontitis patients or, naturally, on the effect of periodontal treatment on salivary sST2 levels.…”

Section: Introductionmentioning

confidence: 99%

Salivary IL‐33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis

Yılmaz

Demir

et al. 2023

Oral Diseases

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ObjectivesToll‐like receptor‐2 (TLR2) signalling pathway is involved in the regulation of interleukin (IL)‐33 and its receptor suppression of tumorigenicity‐2 (ST2). This study aimed to compare salivary IL‐33 and soluble ST2 (sST2) levels of periodontitis patients with those of periodontally healthy individuals in relation to their TLR2 rs111200466 23‐bp insertion/deletion polymorphism within the promoter region.Materials and MethodsUnstimulated saliva samples were collected, and periodontal parameters were recorded from 35 periodontally healthy individuals and 44 periodontitis patients. Non‐surgical treatments were applied to periodontitis patients, and sample collections and clinical measurements were repeated 3 months following therapy. Salivary IL‐33 and sST2 levels were measured with enzyme‐linked immunosorbent assay kits, and TLR2 rs111200466 polymorphism was detected by polymerase chain reaction.ResultsElevated salivary IL‐33 (p = 0.007) and sST2 (p = 0.020) levels were observed in periodontitis patients, in comparison to controls. sST2 levels declined 3‐months following treatment (p < 0.001). Increased salivary IL‐33 and sST2 levels were found to be associated with periodontitis, with no significant relation to the TLR2 polymorphism.ConclusionPeriodontitis, but not TLR2 rs111200466 polymorphism, is associated with elevated salivary sST2 and possibly IL‐33 levels, and periodontal treatment is effective in reducing salivary sST2 levels.

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Peri‐implant crevicular fluid and serum levels of soluble ST2 in peri‐implant diseases: A pilot study

Cited by 5 publications

References 48 publications

Assessment of gingival crevicular fluid levels of IL33 and sST2 in periodontitis patients with stage I-III disease

Assessment of gingival crevicular fluid levels of IL33 and sST2 in periodontitis patients with stage I-III disease

Association between peri-implantitis and systemic inflammation: a systematic review

Salivary IL‐33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis

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