Perfusion-weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIR-HASTE: Comparison with H215O PET measurements

Liu, Ho-Ling Anthony; Kochunov, Peter; Hou, Jin; Pu, Yonglin; Mahankali, Srikanth; Feng, Ching Mei; Yee, Seong Hwan; Wan, Yung Liang; Fox, Peter T.; Gao, Jia

doi:10.1002/1522-2594(200103)45:3<431::aid-mrm1056>3.0.co;2-e

Cited by 64 publications

(44 citation statements)

References 37 publications

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“…Unfortunately, EPI is extremely sensitive to susceptibility artifacts, which results in spatial misregistration and signal voiding in the vicinity of magnetic field inhomogeneities. Several different data-recording strategies for FAIR ASL have been developed to overcome this limitation based on single-shot FSE imaging (11,12). However, these approaches have the disadvantage of significant blurring due to relatively long echo trains.…”

Section: Discussionmentioning

confidence: 99%

“…The most extensively used data acquisition technique for ASL is EPI (8 -10), which is extremely sensitive to susceptibility artifacts. Recently, several different ASL techniques have been developed that are insensitive to magnetic field inhomogeneities, including FAIR spin preparation with singleshot rapid acquisition with relaxation enhancement (RARE) (11), FAIR with gradient echo and spin echo (GRASE) (11), FAIR with half-Fourier single-shot turbo spin-echo (HASTE) (12), FAIR with fast low-angle shot (FLASH) (13), and turbo fast low-angle shot (Turbo-FLASH) (14). Single-shot fast spin-echo (FSE) approaches (e.g., RARE and HASTE) are hampered by strong blurring due to T2 decay during the acquisition of relatively long echo trains (15).…”

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confidence: 99%

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FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Boss

Martirosian

Klose

et al. 2007

Magnetic Resonance Imaging

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Purpose:To estimate cerebral blood perfusion in areas of strong magnetic susceptibility changes with high spatial and temporal resolution using a flow-sensitive alternating inversion recovery (FAIR) arterial spin labeling (ASL) method. Materials and Methods:We implemented an ASL method that is capable of imaging perfusion in areas of high magnetic susceptibility changes by combining a FAIR spin preparation with a true fast imaging in steady precession (TrueFISP) data acquisition strategy. A TrueFISP readout sequence was applied especially in regions with magnetic field inhomogeneities and compared with corresponding FAIR measurements obtained with a standard echo-planar imaging (EPI) readout. Quantitative perfusion images were obtained at 1.5 Tesla (1.5T) from eight healthy volunteers (24 -42 years old) and one patient (23 years old). FAIRTrueFISP perfusion images were compared with FAIR echoplanar images. T1 maps, which are necessary for quantitative perfusion estimation, were obtained with inversion recovery (IR) TrueFISP and IR EPI. Additionally, high-resolution perfusion measurements were performed on four volunteers at 3T. Results:The two ASL perfusion imaging modalities yielded comparable diagnostic image quality in brain areas with low susceptibility differences at 1.5T. Cerebral perfusion of gray matter (GM) areas was 105.7 Ϯ 5.2 mL/100 g/minute for FAIR-TrueFISP and 88.8 Ϯ 14.6 mL/100 g/minute for FAIR-EPI at 1.5T, and 70.4 Ϯ 7.1 mL/100 g/minute for FAIR-TrueFISP and 63.5 Ϯ 6.9 mL/100 g/minute for FAIR-EPI at 3.0T. Higher perfusion values at 1.5T were due to more pronounced partial-volume effects from fast moving spins at lower spatial resolution. The FAIR-TrueFISP sequence showed no significant distortions and markedly reduced signal void artifacts in areas of high susceptibility changes (e.g., near brain-bone transitions and close to metallic clips) compared to FAIR-EPI. At 3T, highly resolved FAIR-TrueFISP perfusion images were acquired with an in-plane resolution of up to 1.3 mm.Conclusion: FAIR-TrueFISP allows for assessment of cerebral perfusion in areas of critically high susceptibility changes with conventional ASL methods.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Boss

Martirosian

Klose

et al. 2007

Magnetic Resonance Imaging

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“…Global CBF measurements were also decreased in seizure patients compared with controls. Liu et al 97 applied a single-slice PASL perfusion technique (FAIR-HASTE) in patients with temporal lobe epilepsy, also demonstrating interictal hypoperfusion on the side of seizures which correlated with CBF measures generated with […”

Section: Epilepsymentioning

confidence: 99%

Clinical Neuroimaging Using Arterial Spin-Labeled Perfusion Magnetic Resonance Imaging

2007

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Summary:The two most common methods for measuring perfusion with MRI are based on dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL). Although clinical experience to date is much more extensive with DSC perfusion MRI, ASL methods offer several advantages. The primary advantages are that completely noninvasive absolute cerebral blood flow (CBF) measurements are possible with relative insensitivity to permeability, and that multiple repeated measurements can be obtained to evaluate one or more interventions or to perform perfusion-based functional MRI. ASL perfusion and perfusion-based functional MRI methods have been applied in many clinical settings, including acute and chronic cerebrovascular disease, CNS neoplasms, epilepsy, aging and development, neurodegenerative disorders, and neuropsychiatric diseases. Recent technical advances have improved the sensitivity of ASL perfusion MRI, and increasing use is expected in the coming years. The present review focuses on ASL perfusion MRI and applications in clinical neuroimaging.

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“…Thus, ASL-MRI may provide a useful adjunct tool for resolving diagnostic and methodological questions about cerebral perfusion images. Thus far, ASL-MRI has been demonstrated to be reliable and its results reproducible in the assessment of cerebral blood flow (CBF) in various pathological states, including cerebrovascular disease [26][27][28] , neurodegenerative disease 29,30 , and temporal lobe epilepsy 31,32 . However, to date there have been no clinical studies of DAVF using ASL imaging.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Studies of Intracranial Dural Arteriovenous Fistulas Using Arterial Spin-Labeling MR Imaging

Noguchi

Irié²,

Takase

et al. 2010

Interv Neuroradiol

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Arterial spin-labeling (ASL) magnetic resonance imaging (MRI) enables non-invasive acquisition of the brain perfusion information in cerebrovascular disease. We investigated hemodynamic changes in intracranial dural arteriovenous fistulas (DAVFs) using ASL-MRI. ASL-MRI by a Q2TIPS sequence on a 3.0-Tesla MRI was performed for three patients with Cognard's IIa+b type of DAVFs before and after treatment. Perfusion images obtained by ASL-MRI (ASL images) before treatment were visually compared with those by single-photon emission computed tomography images (SPECT images). Increasing rates of temporal changes of regional perfusion values in ASL images (ASL values) before and after treatment were also calculated. In all three patients, ASL images before treatment demonstrated high perfusion in regions around the shunting areas, where normal or low perfusion were detected on SPECT images; thus, ASL images might have demonstrated the abundant arterial shunting flow via the fistulas. On days eight to 20 after treatment, ASL values around the shunt areas remained the same or decreased, and those in the regions other than the shunt areas increased in all three patients. This might have been due to a combination of the following: a decrease in shunt flow volume, an amelioration of venous congestion, and a sustained an upward shift in the autoregulation of the brain perfusion pressure. All regional ASL values decreased on days 112 and 120 after treatment in two patients, which possibly reflects a reduction in the upward shift in autoregulation. ASL-MRI might be useful for identifying the hemodynamic behavior of DAVFs before and after treatment.

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Perfusion-weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIR-HASTE: Comparison with H215O PET measurements

Cited by 64 publications

References 37 publications

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Clinical Neuroimaging Using Arterial Spin-Labeled Perfusion Magnetic Resonance Imaging

Hemodynamic Studies of Intracranial Dural Arteriovenous Fistulas Using Arterial Spin-Labeling MR Imaging

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