Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients

Abstract

BackgroundThe Frontal Assessment Battery (FAB) is a brief battery of six neuropsychological tasks designed to assess frontal lobe function at bedside [Neurology 55:1621-1626, 2000]. The six FAB tasks explore cognitive and behavioral domains that are thought to be under the control of the frontal lobes, most notably conceptualization and abstract reasoning, lexical verbal fluency and mental flexibility, motor programming and executive control of action, self-regulation and resistance to interference, inhibitory control, and environmental autonomy.MethodsWe examined the sensitivity of performance on the FAB to frontal lobe damage in right-hemisphere-damaged first-ever stroke patients based on voxel-based lesion-behavior mapping.ResultsVoxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score. Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9). Finally, the FAB inhibitory control score was sensitive to damage of the right inferior frontal gyrus (IFG; BA44/45).ConclusionsThese findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease

“…Several studies have investigated this issue [22,23,55]; however, only a few studies have discussed WMHs and FAB [56]. In the present study, we found a strong association between TFAB performance and white matter changes within frontal and lateral periventricular regions and subcortical deep brain nuclei in the patients with both MCI-V and MCI-A.…”

“…It has been widely applied in studies on various target groups [17,18,19,20,21]. Researchers have discovered that neural substrates related to performances on the FAB include both cortical and subcortical areas, such as the middle frontal gyrus, inferior frontal, insula [22], callosomarginal, and precentral regions [23]. Previous studies have also shown that the FAB is useful in differentiating AD from subcortical VaD [24].…”

Longitudinal profile of iron accumulation in good‐grade subarachnoid hemorrhage

“…The FAB provides a useful screening instrument for executive dysfunction as shown in several clinical investigations, including studies on Parkinson's disease, Alzheimer's disease, or stroke 20, 43, 44. Brain imaging studies revealed positive correlations of decreased FAB scores indicating executive dysfunction and reductions of brain tissue perfusion located to the left middle frontal gyrus and the right superior frontal gyrus in patients with MCI, Alzheimer's disease, and frontotemporal lobe dementias 45, 46, 47.…”

Вплив Периферичної Діабетичної Сенсомоторної Нейропатії На Стан Когнітивних Функцій У Хворих На цукровий Діабет 2-Го Типу Похилого Віку

“…БЛД включала визначення кон-цептуалізації, швидкості мовлення, динамічного праксису, просту та складну реакцію вибору та дослідження хватальних рефлексів. Якщо пацієнт набирав 18-16 балів, це відповідало нормальним когнітивним функціям, 15-12 балів -свідчило про помірну лобну дисфункцію за відсутності де-менції, а 11 балів та нижче -про деменцію лобно-го типу [11][12][13].…”