Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor

Chinowsky, Timothy M.; Quinn, John; Bartholomew, D. U.; Kaiser, Robert; Elkind, J. L.

doi:10.1016/s0925-4005(03)00113-8

Cited by 166 publications

(106 citation statements)

References 6 publications

Supporting

Mentioning

101

Contrasting

Order By: Relevance

“…In angular or spectral interrogation methods, the determination of SPR dip position involves a series of intensity data from different incident angles or wavelengths, and the abundance of data has helped to suppress the intensity noise and greatly improve the signal to noise ratio. Thus, the refractive index resolution in both modulation methods has been improved down to 10 −6 level [36,31]. Various averaging and mathematical treatment methods can be further used to lower the detection limit down to 10 −7 RIU level [31,30].…”

Section: Surface Plasmon Resonance: Phase Vs Amplitudementioning

confidence: 99%

“…Thus, the refractive index resolution in both modulation methods has been improved down to 10 −6 level [36,31]. Various averaging and mathematical treatment methods can be further used to lower the detection limit down to 10 −7 RIU level [31,30]. The angular or wavelength modulation method, however, requires a linear detector for refractive index measurement of a single point on the SPR cell.…”

Section: Surface Plasmon Resonance: Phase Vs Amplitudementioning

confidence: 99%

“…As an example, Chinowsky et al [31] reported the achievement of the detection limit of 2 × 10 −7 RIU after mathematical processing of signals in a simple amplitude-sensitive scheme of spectral interrogation. To make comparative, self-consistent review, we need to clearly separate three different types of works: (i) works, in which the LOD is determined (and limited) by the level of instrumental and environmental (temperature and inertial drifts etc.)…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

View full text Add to dashboard Cite

International audienceSurface Plasmon Resonance (SPR) has become a central tool for label-free characterization of biomolecular interactions. Based on monitoring of amplitude characteristics, conventional SPR sensors have been extensively explored, commercialized and applied for studies of many important interactions (antigen-antibody, protein-ligand etc), but this technology still lacks of sensitivity for the detection of relatively small and low copy number compounds. Phase-sensitive SPR has recently emerged as an upgrade of this technology to resolve the sensitivity issue. Profiting from a sharp phase jump under SPR and ultra-sensitive tools of its control, this technology offers up to 100-time improvement of the detection limit, giving access to the detection of trace amounts of small molecular weight analytes (drugs etc). This paper intends to provide a tutorial on basic concepts of phase detection in SPR sensing, compare the performance of phase- and amplitude-sensitive sensors, review recent progress in the development and applications of phase-sensitive SPR sensors, and outline future prospects and trends of this technology

show abstract

Section: Surface Plasmon Resonance: Phase Vs Amplitudementioning

confidence: 99%

Section: Surface Plasmon Resonance: Phase Vs Amplitudementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

View full text Add to dashboard Cite

show abstract

“…This change in refractive index is measured in real time, and the result is plotted as response or resonance units (RUs) versus time (a sensorgram) 25 . The miniature SPR sensing chip, described by Soelberg 26 , et al and Chinowsky 27,28 , et al, is a fully integrated SPR sensor element. Its main components ( Fig.…”

Section: Gold Nanoparticle-enhanced Surface-plasmonmentioning

confidence: 99%

Nanoparticle-based Sensors

Khanna

2008

DSJ

View full text Add to dashboard Cite

Nanoparticles exhibit several unique properties that can be applied to develop chemical and biosensors possessing desirable features like enhanced sensitivity and lower detection limits. Gold nanoparticles are coated with sugars tailored to recognise different biological substances. When mixed with a weak solution of the sugar-coated nanoparticles, the target substance, e.g., ricin or E.coli, attaches to the sugar, thereby altering its properties and changing the colour. Spores of bacterium labeled with carbon dots have been found to glow upon illumination when viewed with a confocal microscope. Enzyme/nanoparticle-based optical sensors for the detection of organophosphate (OP) compounds employ nanoparticle-modified fluorescence of an inhibitor of the enzyme to generate the signal for the OP compound detection. Nanoparticles shaped as nanoprisms, built of silver atoms, appear red on exposure to light. These nanoparticles are used as diagnostic labels that glow when target DNA, e.g., those of anthrax or HIV, are present. Of great importance are tools like gold nanoparticle-enhanced surface-plasmon resonance sensor and silver nanoparticle surface-enhanced portable Raman integrated tunable sensor. Nanoparticle metal oxide chemiresistors using micro electro mechanical system hotplate are very promising devices for toxic gas sensing. Chemiresistors comprising thin films of nanogold particles, encapsulated in monomolecular layers of functionalised alkanethiols, deposited on interdigitated microelectrodes, show resistance changes through reversible absorption of vapours of harmful gases. This paper reviews the state-of-the-art sensors for chemical and biological terror agents, indicates their capabilities and applications, and presents the future scope of these devices.

show abstract

“…SPR has been involved in many applications in engineering, biotechnology, and other life science disciplines. In the past two decades, SPR had played a vital role in many promising sensing applications in biological and chemical systems [11][12][13][14][15]. Recently, LC coupled with SPR phenomenon has been widely utilized in sensing applications.…”

mentioning

confidence: 99%

Study of the Effect of Nematic Order Degradation in Liquid Crystal-Based Surface Plasmon Resonance Sensors

Abu-Abed

2017

Photonics

View full text Add to dashboard Cite

This paper presents a new analysis of optical sensors based on surface plasmon resonance (SPR) phenomenon and nematic liquid crystal (LC) sensitive layer in the partially ordered state. In particular, the paper studies the influence of degradation in the LC ordering state on the behavior of the plasmon resonance parameters. The degradation in the LC ordering is represented by the order parameter. The explicit treatment of the order parameter is critical when trying to differentiate between a change in alignment and a degradation of alignment in LC in response to the presence of an external stimulus in LC based sensors. When a reduction in ordering occurs, ignoring the order parameter can produce misleading results. This sensor has potential applications in chemical and biological systems. The paper presents a tracking method for the state of alignment and degree of ordering of the partially ordered LC film. This can be achieved via the SPR propagation constant and the critical angle at the interface between a metal and an LC film.

show abstract

Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor

Cited by 166 publications

References 6 publications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Nanoparticle-based Sensors

Study of the Effect of Nematic Order Degradation in Liquid Crystal-Based Surface Plasmon Resonance Sensors

Contact Info

Product

Resources

About