Performance of the GenoType MTBDRsl V 2.0 for detecting second-line drugs resistance of Mycobacterium tuberculosis isolates in Tunisia

Bouzouita, Imen; Draoui, Henda; Cabibbe, Andrea Maurizio; Essalah, Leila; Bejaoui, Sana; Trovato, Alberto; Messadi, F.; Cirillo, Daniela María; Slim-Saidi, Leila

doi:10.1016/j.resmic.2021.103816

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The overall pooled prevalence of XDR-TB pattern estimated by the DST was assessed in 28 (73.7%) studies 26,27,29,56,58,59,61 and was 15% (95% CI = 11-20; I 2 = 95.6%). The pooled prevalence of resistance was higher for fluoroquinolones (FQ) (34%; 95% CI = 27-41; I 2 = 97.6%), followed by kanamycin (KAN) (28%; 95% CI = 21-36; I 2 = 97%), amikacin (AMK) (18%; 95% CI = 14-23; I 2 = 93.6%), and capreomycin (CM) (17%; 95% CI = 13-21; I 2 = 92%) (Fig.…”

Section: Resistance Patternsmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Diagnosis of XDR and Pre-XDR TB: A Systematic Review of Available Tools

Saderi¹,

Puci²,

Lorenzo³

et al. 2022

Archivos de Bronconeumología

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Section: Resistance Patternsmentioning

confidence: 99%

“…The pooled proportion of diagnostic sensitivity and specificity of GenoType MTBDRsl VER 2.0 in detecting XDR-TB were evaluated by 9 out of 10 (90%) studies, 26,27,29,34,35,39,40,42,47 and were 85% (95% CI = 72-94; I 2 = 75.6%) and 98% (95% CI = 95-100; I 2 = 88.3%), respectively (Figs. 3 and 4).…”

Section: Genotype Mtbdrsl Ver 20mentioning

confidence: 99%

Rapid Diagnosis of XDR and Pre-XDR TB: A Systematic Review of Available Tools

Saderi¹,

Puci²,

Lorenzo³

et al. 2022

Archivos de Bronconeumología

View full text Add to dashboard Cite

Combating the menace of antimicrobial resistance in Africa: a review on stewardship, surveillance and diagnostic strategies

et al. 2022

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The emergence of antibiotic-resistant pathogens has threatened not only our ability to deal with common infectious diseases but also the management of life-threatening complications. Antimicrobial resistance (AMR) remains a significant threat in both industrialized and developing countries alike. In Africa, though, poor clinical care, indiscriminate antibiotic use, lack of robust AMR surveillance programs, lack of proper regulations and the burden of communicable diseases are factors aggravating the problem of AMR. In order to effectively address the challenge of AMR, antimicrobial stewardship programs, solid AMR surveillance systems to monitor the trend of resistance, as well as robust, affordable and rapid diagnostic tools which generate data that informs decision-making, have been demonstrated to be effective. However, we have identified a significant knowledge gap in the area of the application of fast and affordable diagnostic tools, surveillance, and stewardship programs in Africa. Therefore, we set out to provide up-to-date information in these areas. We discussed available hospital-based stewardship initiatives in addition to the role of governmental and non-governmental organizations. Finally, we have reviewed the application of various phenotypic and molecular AMR detection tools in both research and routine laboratory settings in Africa, deployment challenges and the efficiency of these methods.

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Performance of the GenoType MTBDRsl V 2.0 for detecting second-line drugs resistance of Mycobacterium tuberculosis isolates in Tunisia

Cited by 2 publications

References 15 publications

Rapid Diagnosis of XDR and Pre-XDR TB: A Systematic Review of Available Tools

Rapid Diagnosis of XDR and Pre-XDR TB: A Systematic Review of Available Tools

Combating the menace of antimicrobial resistance in Africa: a review on stewardship, surveillance and diagnostic strategies

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