A newly developed graded-index polymer optical fiber (GI-POF) with high-temperature and high-humidity stability was proposed. As it was found that the high numerical aperture and high glass transition temperature () at the core center of the GI-POF were key issues to achieve both high-temperature and humidity stability, a partially fluorinated polymer material was adopted to obtain both characteristics in the GI-POF. The newly developed GI-POF had low-loss (140 dB/km at 650-nm wavelength), high-bandwidth (higher than 1 GHz for 100 m transmission), high-temperature and humidity stability at 70 C, 80% relative humidity (R.H.) and low bending loss. Index Terms-Graded-index polymer optical fiber (GI-POF), high-temperature stability, glass transition temperature, numerical aperture, partially fluorinated polymer.