Performance of new 400‐MHz HTS power‐driven magnet NMR technology on typical pharmaceutical API, cinacalcet HCl

Elipe, Maria Victoria Silva; Donovan, N.; Krull, Robert; Pooke, D.; Colson, Kimberly L.

doi:10.1002/mrc.4795

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…470,471 Furthermore, the HTS can be used in another very interesting area of NMR spectroscopy, viz., in the construction of cryogen-free powerdriven magnets, as was shown by an HTS magnet operating at 9.4 T corresponding to a 1 H frequency of 400 MHz. 472 The operation temperature of the magnet is 14−18 K, which allows the magnet to maintain the superconducting state, using a high-stability power supply and a helium compressor.…”

Section: Low Field Magnets High-temperature Superconductors and High ...mentioning

confidence: 99%

“…1 H, 15 N-SOFAST-HMQC and 1 H, 15 N-BEST-TROSY NMR spectra of proteins at 1.2 GHz have been acquired and were compared with respect to resolution and sensitivity to spectra obtained at 900 and 950 MHz, which resulted in clear improvements at the highest magnetic field; these results are promising for future applications to glycans using ultra-high field NMR spectroscopy at > 1 GHz. To obtain even higher magnetic field strengths for NMR spectrometers operated in a persistent mode, it will be essential to construct high quality superconducting joints between HTS coils as well as between HTS and LTS wires in order to reach such goals. , Furthermore, the HTS can be used in another very interesting area of NMR spectroscopy, viz., in the construction of cryogen-free power-driven magnets, as was shown by an HTS magnet operating at 9.4 T corresponding to a 1 H frequency of 400 MHz . The operation temperature of the magnet is 14–18 K, which allows the magnet to maintain the superconducting state, using a high-stability power supply and a helium compressor.…”

Section: Technological Developmentsmentioning

confidence: 99%

See 1 more Smart Citation

Primary Structure of Glycans by NMR Spectroscopy

Fontana

Widmalm

2023

Chem. Rev.

View full text Add to dashboard Cite

Glycans, carbohydrate molecules in the realm of biology, are present as biomedically important glycoconjugates and a characteristic aspect is that their structures in many instances are branched. In determining the primary structure of a glycan, the sugar components including the absolute configuration and ring form, anomeric configuration, linkage(s), sequence, and substituents should be elucidated. Solution state NMR spectroscopy offers a unique opportunity to resolve all these aspects at atomic resolution. During the last two decades, advancement of both NMR experiments and spectrometer hardware have made it possible to unravel carbohydrate structure more efficiently. These developments applicable to glycans include, inter alia, NMR experiments that reduce spectral overlap, use selective excitations, record tilted projections of multidimensional spectra, acquire spectra by multiple receivers, utilize polarization by fast-pulsing techniques, concatenate pulse-sequence modules to acquire several spectra in a single measurement, acquire pure shift correlated spectra devoid of scalar couplings, employ stable isotope labeling to efficiently obtain homo-and/or heteronuclear correlations, as well as those that rely on dipolar cross-correlated interactions for sequential information. Refined computer programs for NMR spin simulation and chemical shift prediction aid the structural elucidation of glycans, which are notorious for their limited spectral dispersion. Hardware developments include cryogenically cold probes and dynamic nuclear polarization techniques, both resulting in enhanced sensitivity as well as ultrahigh field NMR spectrometers with a 1 H NMR resonance frequency higher than 1 GHz, thus improving resolution of resonances. Taken together, the developments have made and will in the future make it possible to elucidate carbohydrate structure in great detail, thereby forming the basis for understanding of how glycans interact with other molecules.

show abstract

Section: Low Field Magnets High-temperature Superconductors and High ...mentioning

confidence: 99%

Section: Technological Developmentsmentioning

confidence: 99%

Primary Structure of Glycans by NMR Spectroscopy

Fontana

Widmalm

2023

Chem. Rev.

View full text Add to dashboard Cite

show abstract

Current–voltage characteristics of double disordered REBCO coated conductors exposed to magnetic fields with edge gradients

Gnilsen

Usoskin

Eisterer

et al. 2019

Supercond. Sci. Technol.

View full text Add to dashboard Cite

A study of HTS-coated tapes which are exposed to a low and medium field with a gradient in the flux density is performed in order to enable relevant and accurate tape characterization as well as to determine the relevant information for applications, where a magnetic field gradient occurs. In particular, the study is focused on ultra-high-magnet-field YBCO-coated tapes. Such tapes based on double disordered YBCO layer with intrinsic and extrinsic precipitations exhibit a ‘champion’ performance in ultra-high (31 T) magnetic fields. Alternative measurement techniques, based on miniature permanent magnets or a pulsed electro-magnet was developed to characterize the critical current, I c , in 0.5 and 3 T fields at 77 K, B//c, respectively. For the field dependence of the critical current, an ‘extended alpha approximation’ is suggested, which enables a sufficiently accurate description of the tape behavior in the low and medium field range, i.e. from 0 to 6 T. Local and integral voltage response in the tapes are analyzed and compared with experimental results. Observations of the effect that gains the influence of local I c -inhomogeneities exposed to a spatially confined magnetic field are described and discussed. The effects of local heating and cooling are shown to be limited via lowering the transport currents and finally a reduced power dissipation in the tape exposed to a localized magnetic field with two gradient zones was demonstrated. Correction factors needed to determine the critical current from the field dependence of the integral voltage response are derived and discussed.

show abstract

Performance of new 400‐MHz HTS power‐driven magnet NMR technology on typical pharmaceutical API, cinacalcet HCl

Cited by 2 publications

References 0 publications

Primary Structure of Glycans by NMR Spectroscopy

Primary Structure of Glycans by NMR Spectroscopy

Current–voltage characteristics of double disordered REBCO coated conductors exposed to magnetic fields with edge gradients

Contact Info

Product

Resources

About