Performance of functionality measures and phase angle in women exposed to chemotherapy for early breast cancer

Silva, Bruna Ramos da; Mialich, Mirele Savegnago; Cruz, Loris P.; Rufato, Sarah; Gozzo, Thaís de Oliveira; Jordão, Alceu Afonso

doi:10.1016/j.clnesp.2021.02.007

Cited by 18 publications

(25 citation statements)

References 73 publications

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“…This last data is in agreement with those by Ramos da Silva et al [39]., which show signi cant differences in PhA before and after the beginning of the chemotherapy, suggesting that treatment related toxicities might have a negative impact on patient's prognosis.…”

Section: Discussionsupporting

confidence: 92%

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

Vignini

Copparoni

Pelati

et al. 2022

Preprint

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Purpose This study evaluated whether a series of analyses that are associated with physical state decay, such as phase angle (PhA), obtained by bio-electrical impedance analysis (BIA) performed before the first cycle (t0) and after 1-2 months (t1) of chemotherapy, might be associated with differences in a series of clinical factors. Methods In this monocentric, prospective, observational study we enrolled patients affected by solid tumors (breast or gastrointestinal cancers) treated with chemotherapy at our Institution between February and July 2019. We calculated whether a series of clinical factors (age, sex, type of chemotherapy regimen, metastatic vs not-metastatic disease involvement and different tumor type) might be associated with changes in PhA. BIA analysis was performed with DF50 Body Composition Analyzer. Statistical analysis was performed with statistical software R (4.1.0) and MedCalc® Statistical Software version 19.7.2. Results Thirty patients were enrolled, treated with chemotherapy in neoadjuvant, adjuvant or first line metastastic setting. In the whole cohort of patients, it was observed a reduction of PhA (p=0.02) between t0 and t1. Stratifying by clinical variables, female patients (p=0.02), younger patients (p=0.02), predominantly with not-metastatic involvement (p=0.03), affected by breast cancer (p<0.01) and who received taxane-based chemotherapy (p=0.01) were those a statistically significant difference in PhA between t0 and t1 was observed. Conclusion Our study suggest that PhA decrease is frequent as neoplastic disease worsens. BIA is an effective method for detecting PhA that seems to be a good indicator of patient’s malnutrition state. Selected subgroups of patients might be at higher risk of PhA decrease (females, breast cancer patients, younger patients, those treated with taxanes) and should be offered prompt nutritional assessment and support. Further studies in these subgroups of patients are recommended.

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Section: Discussionsupporting

confidence: 92%

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

Vignini

Copparoni

Pelati

et al. 2022

Preprint

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“…PhA can be affected by specific elements of the disease, infection, inflammation, or oxidative stress [ 22 , 39 ]. In this sense, PhA has been proposed as an independent predictor of disease severity in clinical conditions, such as malnutrition [ 40 ], increased nutritional risk [ 41 ], and sarcopenia [ 42 ]. These conditions all have inflammation in common [ 43 ], which affects tissue electrical properties, body cell mass, cell membrane integrity, and ultimately PhA [ 44 ].…”

Section: Phase Angle and Its Determinantsmentioning

confidence: 99%

Phase angle and cellular health: inflammation and oxidative damage

Silva

Orsso

Gonzalez

et al. 2022

Rev Endocr Metab Disord

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Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle has potential utility in early detecting inflammatory and oxidative status. Herein, we aimed to critically review the current understanding on the determinants of phase angle and its relationship with markers of inflammation and oxidative stress. We also discussed the potential role of phase angle in detecting chronic inflammation and related adverse outcomes. Several factors have been identified as predictors of phase angle, including age, sex, extracellular to intracellular water ratio, and fat-free mass. In addition to these factors, body mass index (BMI) also seems to influence phase angle. Available data also show that lower phase angle values are correlated (negligible to high correlation coefficients) with higher c-reactive protein, tumour necrosis factor-α, interleukin-6, and interleukin-10 in studies involving the general and aging populations, as well as patients with chronic conditions. Although fewer studies have evaluated the relationship between phase angle and markers of oxidative stress, available data also suggest that phase angle has potential to be used as an indicator (for screening) of oxidative damage. Future studies including diverse populations and bioelectrical impedance devices are required to confirm the validity and accuracy of phase angle as a marker of inflammation and oxidative stress for clinical use.

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“…In this study, the global health, functional, and symptom scales of both questionnaires exhibited better QOL scores than the scores reported in studies that evaluated women undergoing chemotherapy or radiotherapy. ( 18 - 20 )…”

Section: Discussionmentioning

confidence: 99%

Quality of life of women who underwent breast cancer treatment relative to sociodemographic, behavioral, and clinical factors

Campos,

Bustamante-Teixeira,

Ervilha

et al. 2024

Einstein (São Paulo)

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Objective Patients with cancer often undergo multiple extended treatments that decrease their quality of life. However, the quality of life of women with breast cancer after they undergo treatment remains underexplored in Brazil. Therefore, this study determined sociodemographic, behavioral, and clinical factors related to the post-treatment quality of life of women with breast cancer. Methods This cross-sectional study involved 101 women diagnosed with breast cancer between 2014 and 2016 and treated at a Brazilian Oncology Reference Service. Data were collected from them using face-to-face surveys. Quality of life was evaluated using the European Organization for the Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C30) and EORTC Breast Cancer-specific Quality of Life questionnaire (EORTC QLQ-BR23). The data collected were analyzed using Student’s t-test and Mann-Whitney U test. Results The median score on the global health, functional, and symptom scales of the EORTC QLQ-C30 was 75.00 (Interquartile range=33.33), 75.99 (Standard deviation [SD]=19.26), and 19.67 (SD=16.91), respectively. The mean score on the functional and symptom scales of the EORTC QLQ-BR23 was 61.89 (SD=17.21) and 20.12 (SD=16.94), respectively. Furthermore, higher post-treatment quality of life was found to be associated with being aged 50 or more, being Black, having eight or more years of education, having a partner, having a paying job, receiving treatment from the private healthcare system, having a higher income, living in the municipality where healthcare services are availed, engaging in physical activity, not smoking, being more religious, having more social support, not being overweight, having no comorbidities, and undergoing lumpectomy. Conclusion Sociodemographic, behavioral, and clinical factors significantly impact the quality of life of women who undergo breast cancer treatment. Implementing interventions that improve health and reducing inequalities in the access to healthcare services can improve the quality of life of these patients.

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Performance of functionality measures and phase angle in women exposed to chemotherapy for early breast cancer

Cited by 18 publications

References 73 publications

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

Phase angle and cellular health: inflammation and oxidative damage

Quality of life of women who underwent breast cancer treatment relative to sociodemographic, behavioral, and clinical factors

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