Phase angle and cellular health: inflammation and oxidative damage

Silva, Bruna Ramos da; Orsso, Camila E.; Gonzalez, Maria Cristina; Sicchieri, Juliana Maria Faccioli; Mialich, Mirele Savegnago; Júnior, Alceu Afonso Jordão; Prado, Carla M.

doi:10.1007/s11154-022-09775-0

Cited by 24 publications

(2 citation statements)

References 108 publications

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“…Although fewer studies have evaluated the relationship between PhA and markers of oxidative stress, available data also suggest that PhA may be a potential indicator of oxidative damage. Future studies, including diverse pathologies, are required to confirm the validity and accuracy of PhA as a marker of inflammation and oxidative stress for clinical use [46,47].…”

Section: Obesity and Metabolic Diseasesmentioning

confidence: 99%

Future lines of research on phase angle: Strengths and limitations

Guerrero

García-García

Talluri³

et al. 2023

Rev Endocr Metab Disord

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Bioelectrical impedance analysis (BIA) is the most widely used technique in body composition analysis. When we focus the use of phase sensitive BIA on its raw parameters Resistance (R), Reactance (Xc) and Phase Angle (PhA), we eliminate the bias of using predictive equations based on reference models. In particular PhA, have demonstrated their prognostic utility in multiple aspects of health and disease. In recent years, as a strong association between prognostic and diagnostic factors has been observed, scientific interest in the utility of PhA has increased. In the different fields of knowledge in biomedical research, there are different ways of assessing the impact of a scientific-technical aspect such as PhA. Single frequency with phase detection bioimpedance analysis (SF-BIA) using a 50 kHz single frequency device and tetrapolar wrist-ankle electrode placement is the most widely used bioimpedance approach for characterization of whole-body composition. However, the incorporation of vector representation of raw bioelectrical parameters and direct mathematical calculations without the need for regression equations for the analysis of body compartments has been one of the most important aspects for the development of research in this area. These results provide new evidence for the validity of phase-sensitive bioelectrical measurements as biomarkers of fluid and nutritional status. To enable the development of clinical research that provides consistent results, it is essential to establish appropriate standardization of PhA measurement techniques. Standardization of test protocols will facilitate the diagnosis and assessment of the risk associated with reduced PhA and the evaluation of changes in response to therapeutic interventions. In this paper, we describe and overview the value of PhA in biomedical research, technical and instrumental aspects of PhA research, analysis of Areas of clinical research (cancer patients, digestive and liver diseases, critical and surgical patients, Respiratory, infectious, and COVID-19, obesity and metabolic diseases, Heart and kidney failure, Malnutrition and sarcopenia), characterisation of the different research outcomes, Morphofunctional assessment in disease-related malnutrition and other metabolic disorders: validation of PhA with reference clinical practice techniques, strengths and limitations. Based on the detailed study of the measurement technique, some of the key issues to be considered in future PhA research. On the other hand, it is important to assess the clinical conditions and the phenotype of the patients, as well as to establish a disease-specific clinical profile. The appropriate selection of the most critical outcomes is another fundamental aspect of research.

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Section: Obesity and Metabolic Diseasesmentioning

confidence: 99%

Future lines of research on phase angle: Strengths and limitations

Guerrero

García-García

Talluri³

et al. 2023

Rev Endocr Metab Disord

View full text Add to dashboard Cite

show abstract

“…Although it is well demonstrated that static factors, including age, sex, BMI, body composition (e.g., FFM) are associated with PhA, accumulating information indicates that dynamic factors, such as inflammation and oxidative damage, can directly impact PhA values in conditions that affect cell membrane integrity and function. Da Silva et al [23] review the emerging experimental evidence of mechanistic roles for associations of inflammation and oxidative damage in diversity of PhA values in health and disease.…”

mentioning

confidence: 99%