Performance of elderly white and African American community residents on the abbreviated CERAD Boston naming test

Gg, Fillenbaum; Huber, Marc; Im, Taussig

doi:10.1080/01688639708403851

Cited by 28 publications

(21 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…et al Fillenbaum et al, 1997;Manly et al, 1998) and with data from the pilot for this study derived from white and African Caribbean participants in a different area of south London who had been sampled by household enumeration . Normative data were calculated for all tests in the form of cumulative percentages.…”

Section: Discussionmentioning

confidence: 99%

Cognitive function in UK community‐dwelling African Caribbean elders: normative data for a test battery

Stewart

Richards

Brayne

et al. 2001

Int J Geriat Psychiatry

View full text Add to dashboard Cite

Many 'first generation' African Caribbean residents in the UK have now reached ages where risk of cognitive impairment and dementia starts to increase. In addition, conditions which may impair cognitive function, such as hypertension, diabetes and stroke, have high prevalence rates in African Caribbean populations. However, there is a lack of normative data for cognitive tests in this ethnic group. Cognitive assessment was carried out in a south London community population of 285 African Caribbean participants aged 55-75 years. Tests were drawn principally from the consortium to establish a registry for Alzheimer's disease (CERAD) battery (Boston Naming Test, verbal fluency, word list recall, and Trailmaking Tests A and B) and also included orientation items from the Mini-Mental State Examination (MMSE) and the Clock Drawing Test. Independent effects of age, sex, education and occupation were identified on scores for most but not all cognitive tests. Compared with normative data for African American populations, lower scores on verbal fluency and the Boston Naming Test were observed but scores on memory tests were comparable. Normative data for the tests are presented, stratified by level of education.

show abstract

Section: Discussionmentioning

confidence: 99%

Cognitive function in UK community‐dwelling African Caribbean elders: normative data for a test battery

Stewart

Richards

Brayne

et al. 2001

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

“…However, there is little information in this area, and the multiple potential confounders, such as education quality, do not allow for easy interpretation of some results. For example, some studies have indicated ethnicity-related lower language test scores in the cognitively normal elderly and in those with AD [67,68]. Yet when adjusted for reading level, no significant ethnicity-related differences in language assessments of African Americans and Caucasians with AD were apparent [69].…”

Section: Discussionmentioning

confidence: 99%

Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer’s Disease

Ferguson

Panos

Sloper

et al. 2017

JAD

View full text Add to dashboard Cite

Abstract.Background: Alzheimer's disease (AD) presents with an earlier onset age and increased symptom severity in African Americans and Hispanics. Objective: Although the prevalence of plaques and tangles may not exhibit ethnicity-related differences, levels of neurodegenerative proteins have not been described. Methods: Here, levels of five proteins (i.e., S100B, sRAGE, GDNF, A␤ 40 , and A␤ 42 ) and the A␤ 42 /A␤ 40 ratio were measured in postmortem samples of the middle temporal gyrus (BA21) from age-matched African Americans and Caucasians with AD (n = 6/gender/ethnicity). Results: S100B levels were increased 17% in African Americans (p < 0.003) while sRAGE was mildly decreased (p < 0.09). A␤ 42 levels were increased 121% in African Americans (p < 0.02), leading to a 493% increase in the A␤ 42 /A␤ 40 ratio (p < 0.002). Analysis of GDNF levels did not indicate any significant effects. There were no significant effects of gender and no significant ethnicity with gender interactions on any analyte. Effect size calculations indicated "medium" to "very large" effects. Conclusion: S100B is typically elevated in AD cases; however, the increased levels in African Americans here may be indicative of increased severity in specific populations. Increased A␤ 42 /A␤ 40 ratios in the current study are compatible with increased disease severity and might indicate increased AD pathogenesis in African Americans. Overall, these results are compatible with a hypothesis of increased neuroinflammation in African Americans with AD.

show abstract

“…Previous studies have reported significant differences in neuropsychological performance between Englishspeaking samples from different cultures in the United States [19] even after controlling for demographic variables such as age, education and sex [20] . These differences might be expected to be even more significant when comparing samples that speak different languages given that some neuropsychological concepts may not translate well into other languages.…”

Section: Discussionmentioning

confidence: 99%

The Neuropsychological Performance of Nondemented Puerto Rican Nonagenarians

Carrión-Baralt

Meléndez-Cabrero

Beeri

et al. 2009

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: While the oldest old are the fastest growing segment of the US population, normative neuropsychological data for nondemented oldest old Spanish speakers are nonexistent. This study sought to evaluate the neuropsychological performance of nondemented nonagenarians residing in Puerto Rico and to compare their results with those of a similar English-speaking sample from New York. Methods: We studied 81 subjects who had a complete CERAD neuropsychological assessment in Spanish. We used multiple regression analysis to predict performance on the CERAD battery and ANCOVA to compare the Puerto Rico and New York samples. Results: In 10 out of the 13 neuropsychological tests administered, education was a significant predictor of performance. There were significant differences between the Puerto Rico and New York groups only in the Trail Making Tests. Conclusions: In this Puerto Rican sample, education was the strongest predictor of neuropsychological performance, which is consistent with previous studies. When education level is properly accounted for, the performance of Puerto Rican nonagenarians in the CERAD battery does not differ from the performance of US English-speaking nonagenarians.

show abstract

Performance of elderly white and African American community residents on the abbreviated CERAD Boston naming test

Cited by 28 publications

References 19 publications

Cognitive function in UK community‐dwelling African Caribbean elders: normative data for a test battery

Cognitive function in UK community‐dwelling African Caribbean elders: normative data for a test battery

Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer’s Disease

The Neuropsychological Performance of Nondemented Puerto Rican Nonagenarians

Contact Info

Product

Resources

About