Performance of different definitions of metabolic syndrome for children and adolescents in a 6-year follow-up: Tehran Lipid and Glucose Study (TLGS)

Mirmiran, Parvin; Sherafat-Kazemzadeh, Roya; Farahani, Sara Jalali; Asghari, Golaleh; Niroomand, Mahtab; Momenan, Amirabbas; Azizi, Fereidoun

doi:10.1016/j.diabres.2010.05.001

Cited by 12 publications

(13 citation statements)

References 24 publications

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“…We defined CMRFs to be the same variables that are used for adults [16]. These variables included: (1) central adiposity (WC ≥90th percentile, with respect to age and gender, or WC/height≥0.5); (2) impaired glucose metabolism (fasting glucose ≥100 mg/dl or insulin resistance, as defined by HOMA ≥3.16 [17]); (3) dyslipidemia (highdensity lipoprotein cholesterol≤40 mg/dl or triglycerides≥ 110 mg/dl), and (4) hypertension (systolic or diastolic BP ≥95th percentile for age and gender).…”

Section: Definitionsmentioning

confidence: 99%

Cystatin C, cardiometabolic risk, and body composition in severely obese children

et al. 2010

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The aim of this study was to assess the relationship between cystatin C (CysC), cardiometabolic risk factors (CMRFs), and body composition in severely obese children. We evaluated 117 children aged 7-14 years old. Seventy-nine of these were severely obese (body mass index z-score ranging from 2.1 to 8.4), and 38 were children with normal nutrition state. CysC was determined by immunonephelometry. CMRFs (glucose, insulin, high-density lipoprotein cholesterol, triglycerides, homocysteine, uric acid, alanine aminotransferase, and high-sensitivity C-reactive protein) were measured by standard biochemical methods. Blood pressure was evaluated at the clinical examination. Renal function was estimated using the glomerular filtration rate (eGFR) based upon creatinine levels, and body weight (Léger formula). Body composition was assessed by segmental bioelectrical impedance. Obese children at the highest tertile of CysC values were characterized by their aggregation of CMRFs. CysC concentration was associated with insulin resistance, alanine aminotransferase, uric acid, and homocysteine after adjusting for age, gender, and eGFR. CysC values were also correlated with the fat-free mass and specifically with skeletal muscle mass. CysC levels were correlated with CMRFs factors independently of renal function, and affected by skeletal muscle mass in severely obese children, although they are less influenced by this than is creatinine.

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Section: Definitionsmentioning

confidence: 99%

Cystatin C, cardiometabolic risk, and body composition in severely obese children

et al. 2010

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“…In 2010,A study conducted within the framework of TLGS showed that among different definitions of MetS for adolescents (including Cook [25], Duncan [26], Boney [27], Cruz [28] and de Ferranti [29]), the de Ferranti definition is a better predictor for MetS, overweight and obesity in early adulthood. 6 Hence, in the present study, MetS was defined according to the de Ferranti criteria and was characterized as the presence of more than 3 of the following factors: Fasting blood glucose ≥110 mg/dl, triglycerides ≥100 mg/dl, HDL-C <45 mg/dl, for 15 to 19 year old boys and <50 mg/dl for other boys and girls, waist circumference > 75th percentile for age/sex Iranian population (according to the Caspian Study [30]), and systolic or diastolic blood pressure ≥ 90th percentile for height, age and sex. Systolic and diastolic blood pressure percentiles were defined according to the tables published by the American Academy Of Pediatrics [31], which have been reported for 1 to 17 year olds.…”

Section: Metabolic Syndrome and Overweight Definitionsmentioning

confidence: 99%

“…Like other developing countries, Iran is also experiencing global epidemic obesity and its consequences [4]. The prevalence of MetS among Iranian children and adolescent was 14% [5] , and among Tehranian adolescents was 6.7%, between 1999 and 200 [6] and 9.5% between 2005 and 2008 [7]. However, it is difficult to compare findings of different researches due to the lack of consensus in metabolic syndrome definition in adolescent [1].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome and its Association with Healthy Eating Index-2005 in Adolescents: Tehran Lipid and Glucose Study

Mohseni-Takalloo¹,

Mirmiran

Hosseini-Esfahani³

et al. 2014

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One of the major epidemiologic public health problems is worldwide metabolic syndrome (MetS). Since the relationship between diet quality and MetS among adolescents in developing countries has not been well understood, the present study aimed to evaluate the association between diet quality, as measured by Healthy Eating Index (HEI-2005) and the prevalence of MetS and its risk factors in a group of Tehranian adolescents. This crosssectional study was conducted on 706 adolescents, aged 10-19 years, within the framework of Tehran Lipid and Glucose Study in 2008-2011. Usual dietary intakes were assessed by valid and reliable semi-quantitative food frequency questionnaire and diet quality score was obtained based on HEI-2005. MetS was determined using the modified de Ferranti definition. There were 706 adolescents, aged 14.8±2.7 years. The overall prevalence of MetS in adolescents was 22.4%. Large waist circumference was the most common component of MetS in both girls and boys. After adjusting for age, sex, energy intake and physical activity, participants who were in the highest quartile of HEI-2005 compared with lowest quartile had lower prevalence of hypertriglyceridemia (OR: 0.62; CI 95%: 0.40-0.96 and P for trend= 0.02), and low serum HDL-C (OR: 0.62; CI 95%: 0.41-0.97 and P for trend= 0.02). No significant difference was observed in odds of MetS, large waist circumference, hyperglycemia and hypertension. Adolescents with dietary pattern more consistent with the HEI-2005, had lower prevalence of hypertriglyceridemia and low serum HDL-C.

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“…As shown in the past studies, prevalence of overweight and obesity is increasing in Iranian adolescents (prevalence of large waist circumference has increased from 12.2% in 1999-2001 to 51.8% in 2008-2011) [25,26]. This indicated that during nutrition transition incorrect eating habits have lead to increased energy intake more than the amount of required and thus overweight and obesity.…”

Section: Discussionmentioning

confidence: 95%

Dietary Fat Intake and Its Relationship with Serum Lipid Profiles in Tehranian Adolescents

Mohseni-Takalloo¹,

Mirmiran

Hosseini-Esfahani³

et al. 2014

JFNR

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Dyslipidemia is an important risk factor for cardiovascular disease (CVD) and an important cause of death in adults. Long-term follow-up studies have demonstrated that dietary fat consumption in children and adolescent is one of these risk factors of dyslipidemia in adulthood. The purpose of the current study was to assess the dietary fat intake of Iranian adolescents and their relationship with serum lipid profiles. In this population based cross-sectional study 717 adolescents (391 girls and 326 boys), aged 10 to 19 years, were randomly selected from the fourth phase of Tehran Lipid and Glucose Study (2008)(2009)(2010)(2011). Usual dietary intakes were assessed using valid and reliable food frequency questionnaire and a fasting blood sample was given from all participants to analyze serum lipid profile. Among serum lipid levels, only triglyceride (TG) concentration was higher significantly in boys. In girls, the percent of energy intake from total fat, poly unsaturated fatty acid (PUFA), mono unsaturated fatty acid (MUFA) and trans fatty acids were higher significantly. After adjustment for sex and age, serum levels of TG and HDL-C showed a significant decreasing and increasing trend according to the quartiles of percent of energy intake from PUFA, respectively. No significant difference was observed between other fatty acids and serum lipid profile. In conclusion, although the percent of calorie intake from fat and different types of fatty acids have effect in determining serum lipids levels, but they are not the most important factors for determining the serum lipid profile.

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Performance of different definitions of metabolic syndrome for children and adolescents in a 6-year follow-up: Tehran Lipid and Glucose Study (TLGS)

Cited by 12 publications

References 24 publications

Cystatin C, cardiometabolic risk, and body composition in severely obese children

Cystatin C, cardiometabolic risk, and body composition in severely obese children

Metabolic Syndrome and its Association with Healthy Eating Index-2005 in Adolescents: Tehran Lipid and Glucose Study

Dietary Fat Intake and Its Relationship with Serum Lipid Profiles in Tehranian Adolescents

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