Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes

Abstract

Purpose Previous studies have shown decreased retrobulbar blood flow in normal tension glaucoma (NTG) compared to healthy controls. This study evaluates the ability of colour Doppler imaging (CDI) to identify patients with NTG. Methods Sixty-two patients with untreated NTG (mean age 57714 years) and 40 agematched controls (mean age 5879 years) were included in a prospective cross-sectional institutional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive indices (RI ¼ (PSV-EDV)/PSV) of the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs) were measured by means of CDI. Using receiver operating characteristic (ROC) curves, sensitivity was determined at 90% specificity. Results Patients with NTG showed significantly decreased PSV (Po0.0001) and EDV (Po0.0001) of the CRA, significantly decreased EDV of the nasal (P ¼ 0.004) and temporal (P ¼ 0.002) PCA, and significantly increased RI of the temporal (P ¼ 0.003) PCAs compared to healthy controls. Sensitivity values at 90% specificity were calculated: PSV of the CRA, 30.6%; EDV of the CRA, 48.4%; EDV of the nasal PCA, 43.9%; EDV of the temporal PCA, 45.9%; and RI of the temporal PCA, 39.3%. Conclusions The power to identify NTG using CDI reaches 48% sensitivity at 90% specificity. Further longitudinal studies are needed to determine the prognostic value of CDI in glaucoma.

Color Doppler imaging and pattern visual evoked potential in normal tension glaucoma and hypertension glaucoma

“…The present study also found the RI of OA was negatively correlated with the MD values in the NTG and HTG patients; the RI of SPCA was negatively correlated with the MD values in the NTG and HTG patients; the RI of OA was positively correlated with the PSD value in the NTG and HTG patients. The PSV of control subjects in present study was higher as reported earlier [39][40][41], which may be contributed to ethnic differences between our study and the earlier reports.…”

“…The present study found that there was no significant difference in the latency and amplitude of P100 between NTG and HTG patients, which was contributed to that NTG and HTG may have the same pathogenesis of RGCs apoptosis and the similar character of retinal nerve fiber loss. Ocular hemodynamics had been shown to be a major factor in the pathogenesis of glaucomatous optic neuropathy [38,39]. Cellini et al [12] found that the patients with open angle glaucoma had the lower PSV and the higher RI of OA and SPCA comparing with that of normal subjects.…”

Feasibility of creating a normative database of colour Doppler imaging parameters in glaucomatous eyes and controls

“…Thirty-two study cohorts from 21 studies provided sufficient information to be included in the multivariate analysis 17 19–21 32 37 39 41 42 48 49 52 53 61 62 64 65 69 76 80 81. Data for PSV in the OA failed Levene's test of equality, and the parameter was dropped from the model.…”

Current Imaging Modalities for assessing Ocular Blood Flow in Glaucoma

“…Bossuyt et al 8 reported that vascular dysregulation in NTG was not affected by the structure and function of the microcirculation or macrocirculation, including arterial stiffness, total peripheral resistance, cardiac output, and both peripheral and central hemodynamics. However, the studies conducted by Plange et al, 9 and Butt et al 10 were contradictory where they found significant association between ocular blood flow parameters and NTG.…”