Feasibility of creating a normative database of colour Doppler imaging parameters in glaucomatous eyes and controls

Abstract

Colour Doppler imaging (CDI) is a frequently cited methodology for quantifying ocular blood flow velocities. This investigation reviews the feasibility of creating a normative database of CDI parameters in glaucoma patients and controls. A literature search was conducted for CDI studies involving glaucomatous eyes. Using data from these studies, a weighted mean was derived for the peak systolic velocity, end diastolic velocity and Pourcelot's resistive index in the ophthalmic, central retinal and posterior ciliary arteries. A multivariate analysis was performed to identify whether methodological characteristics contributed to the inter-study variance in CDI values. Data from 3061 glaucoma patients and 1072 controls were included. The mean values for glaucomatous eyes were within one standard deviation of the values for controls for most CDI parameters. Gender mix (p=0.043), intraocular pressure status (p=0.017), frequency of the ultrasound transducer (p=0.02) and whether the patients were on antihypertensive therapy (p=0.004) contributed to the variance. Methodological differences create inter-study variance in CDI values, complicating the construction of a normative database and limiting its utility. Because the mean values for glaucomatous and normal eyes have overlapping ranges, caution should be used when classifying glaucoma status based on a single CDI measurement.

Therapeutic Targeting of Retinal Immune Microenvironment With CSF-1 Receptor Antibody Promotes Visual Function Recovery After Ischemic Optic Neuropathy

“…It is not surprising that visual contrast sensitivity was highly affected and more so than the visual acuity following RI. Visual contrast sensitivity is shown to be a sensitive measure that detects subtle defects or improvements in primarily retinal ganglion cell functions in human, especially early on in a disease process (61). This was also confirmed in rodent models of retinal neurodegenerative conditions, such as glaucoma, when the contrast sensitivity and visual acuity usually show a great consistency (33,62).…”

Contrast sensitivity, ocular blood flow and their potential role in assessing ischaemic retinal disease

“…For more detailed information on retrobulbar blood flow, several excellent reviews are available (Ehrlich et al. 2010, Rusia et al. 2010).…”

“…Some studies have suggested improvement in CS with medications known to improve the circulation within the retrobulbar blood vessels (Gugleta 2010). For more detailed information on retrobulbar blood flow, several excellent reviews are available (Ehrlich et al 2010, Rusia et al 2010.…”

Personalized medicine in glaucoma management

“…Таким образом, существующее на сегодняшний день представление об участии гемодинамических нарушений в патогенезе глаукомы и в развитии ГОН является доказанным, но весьма относительным. Неоспоримым является лишь факт взаимодействия соматической сосудистой патологии и нарушения кровообращения в глазу, что определяет течение ГОН [33][34][35][36][37].…”