Performance characterization of a quantitative liquid chromatography–tandem mass spectrometric method for 12 macrolide and lincosamide antibiotics in salmon, shrimp and tilapia

Dickson, Leslie C

doi:10.1016/j.jchromb.2014.07.031

Cited by 34 publications

(17 citation statements)

References 15 publications

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“…The mobile phase consisted of an aqueous solution of formic acid and acetonitrile, and the detection was performed with a triple quadrupole MS/MS combined with an electrospray ionization source in the positive mode. The LOD was 0.5 µg/kg, and recoveries were found between 47% and 99% [68].…”

Section: Extraction Of Macrolidesmentioning

confidence: 94%

On the Extraction of Antibiotics from Shrimps Prior to Chromatographic Analysis

et al. 2016

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Abstract:The widespread use of antibiotics in veterinary practice and aquaculture has led to the increase of antimicrobial resistance in food-borne pathogens that may be transferred to humans. Global concern is reflected in the regulations from different agencies that have set maximum permitted residue limits on antibiotics in different food matrices of animal origin. Sensitive and selective methods are required to monitor residue levels in aquaculture species for routine regulatory analysis. Since sample preparation is the most important step, several extraction methods have been developed. In this review, we aim to summarize the trends in extraction of several antibiotics classes from shrimps and give a comparison of performance characteristics in the different approaches.

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Section: Extraction Of Macrolidesmentioning

confidence: 94%

On the Extraction of Antibiotics from Shrimps Prior to Chromatographic Analysis

et al. 2016

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“…The mobile phase consisted of an aqueous solution of formic acid and acetonitrile, and the detection was performed with a triple quadrupole MS/MS combined with an electrospray ionization source in the positive mode. The LOD was 0.5 μg/kg, and recoveries were found between 47% and 99% [68].…”

Section: Extraction Of Macrolidesmentioning

confidence: 95%

Trends in Microextraction Techniques for Sample Preparation

2018

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“…At present, the methods for multi-residue analysis of macrolide antibiotics mainly include high-performance liquid chromatography (HPLC) (Clark, Dowling, & Boison, 2009;De La Huebra, Vincent, Bordin, & Rodriguez, 2005;Edder, Coppex, Cominoli, & Corvi, 2002;Lagan a, 2009;Bogialli, Di Corcia, Lagan a, Mastrantoni, & Sergi, 2007;Dickson, 2014;Dickson, O'Byrne, & Chan, 2012;Granja et al, 2009;Horie, Takegami, Toya, & Nakazawa, 2003;Jacobsen, Halling-Sørensen, Ingerslev, & Hansen, 2004;Thompson, Noot, Calvert, & Pernal, 2005;Wang & Leung, 2009;Yang & Carlson, 2004), and capillary electrophoresis (CE) (Deng, Kang, Li, & Xu, 2007a;Deng, Kang, Li, & Xu, 2007b;Liu, Shi, Liu, & Tian, 2010;Tong, Rao, Zhu, Jiang, & Ding, 2009). Compared to HPLC and LC-MS, CE has the virtue of rapid separation and low reagent consumption.…”

Section: Introductionmentioning

confidence: 99%

Determination of five macrolide antibiotic residues in milk by micellar electrokinetic capillary chromatography with field amplified sample stacking

Hong

Guo

Chen

et al. 2017

Journal of Food Safety

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The aim of this study is to develop a new micellar electrokinetic capillary chromatography with field amplified sample stacking for the determination of five kinds of macrolide antibiotic residues in milk. The main factors that affect the separation and enrichment of these analytes were optimized. The optimum running buffer was composed of 60 mM phosphate, 5 mM sodium cholate, and 1.0 mM cetyltrimethyl ammonium bromide at pH 7.0. The separation voltage was 20 kV and the sample was electrokinetically injected at 10 kV for 120 s. The detection wavelength was set at 195 nm. Under the optimized conditions, the enrichment factor of tilmicosin, erythromycin, clarithromycin, roxithromycin, and tylosin were 866, 565, 908, 702, and 675, respectively. The limits of detection ranged from 0.002 to 0.004 mg/kg. The method shall meet the requirement of their maximum residue limits ruled by China, the European Union, the United States, and other countries. Practical applications The developed method has been applied successfully to the determination of the milk samples spiked at 0.05 and 0.1 mg/kg. The recoveries ranging from 72.8 to 93.7% demonstrate that the method can be applied to the detection of tilmicosin, erythromycin, clarithromycin, roxithromycin, and tylosin residues in milk.

show abstract

Performance characterization of a quantitative liquid chromatography–tandem mass spectrometric method for 12 macrolide and lincosamide antibiotics in salmon, shrimp and tilapia

Cited by 34 publications

References 15 publications

On the Extraction of Antibiotics from Shrimps Prior to Chromatographic Analysis

On the Extraction of Antibiotics from Shrimps Prior to Chromatographic Analysis

Trends in Microextraction Techniques for Sample Preparation

Determination of five macrolide antibiotic residues in milk by micellar electrokinetic capillary chromatography with field amplified sample stacking

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