Performance Characteristics of a Real-Time Polymerase Chain Reaction Assay for the Detection of Epidermal Growth Factor Receptor (EGFR) Mutations in Plasma Samples of Non-Small Cell Lung Cancer (NSCLC) Patients

O’Donnell, Patrick; May, Theresa; DeMartin, Kelli; Ferguson, Jane; Halait, H.; Wen, Wei; Yu, Karen; Scudder, Sid

doi:10.1007/s40291-020-00458-7

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…So far, the detection of EGFR is mainly based on nucleic acids of ctDNA origin, which are currently being applied in clinical practice ( 125 ). Cobas EGFR Mutation Test V2 ® (Roche Diagnostics Inc.) was the first liquid biopsy test to be approved by the United States Food and Drug Administration (FDA) ( 129 ). This test allows the analysis of mutations present in cfDNA fragments, such as exon 19 deletions or exon 21 (L858R) substitution mutations in the EGFR gene.…”

Section: Diagnostic Value Of Egfr + Exosomesmentioning

confidence: 99%

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Rao

Huang

et al. 2023

Front. Immunol.

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As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes are widely present in various body fluids, and therefore they can be used as a potential tool for non-invasive liquid biopsy. The present study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). By targeting epidermal growth factor receptor (EGFR) therapy as a first-line treatment for patients with NSCLC, this study also briefly describes the occurrence of EGRF+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.

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Section: Diagnostic Value Of Egfr + Exosomesmentioning

confidence: 99%

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Rao

Huang

et al. 2023

Front. Immunol.

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“…This test allows the mutations that exist in the cfDNA fraction to be analyzed, such as exon 19 deletions or exon 21 (L858R) substitution mutations in the EGFR gene; however, its ability to detect EGFR-T790M is constrained by 58% sensitivity and 80% specificity. Nevertheless, liquid biopsies using cfDNA can be problematic, largely due to the properties of ctDNA and the detection constraints of the methods, even with assay platforms of the highest sensitivity [115][116][117][118]. Moreover, there is increasing evidence of heterogeneity between different metastatic sites within the same patient.…”

Section: Exosomes As Potential Biomarkersmentioning

confidence: 99%

Exosomes: a new perspective in EGFR-mutated lung cancer

Jouida

McCarthy

Fabre

et al. 2021

Cancer Metastasis Rev

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Exosomes are major contributors in cell to cell communication due to their ability to transfer biological material such as protein, RNA, DNA, and miRNA. Additionally, they play a role in tumor initiation, promotion, and progression, and recently, they have emerged as a potential source of information on tumor detection and may be useful as diagnostic, prognostic, and predictive tools. This review focuses on exosomes from lung cancer with a focus on EGFR mutations. Here, we outline the role of exosomes and their functional effect in carcinogenesis, tumor progression, and metastasis. Finally, we discuss the possibility of exosomes as novel biomarkers in early detection, diagnosis, assessment of prognosis, and prediction of therapeutic response in EGFR-mutated lung cancer.

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Performance Characteristics of a Real-Time Polymerase Chain Reaction Assay for the Detection of Epidermal Growth Factor Receptor (EGFR) Mutations in Plasma Samples of Non-Small Cell Lung Cancer (NSCLC) Patients

Cited by 2 publications

References 27 publications

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Exosomes: a new perspective in EGFR-mutated lung cancer

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