Performance and Cell-Mediated and Humoral Immune Responses in Broilers Fed an Aflatoxin Supplemented Diet

Effect of Dietary L-Threonine and Toxin Binder on Performance, Blood Parameters, and Immune Response of Broilers Exposed to Aflatoxin B1

“…These findings are almost contrary to [ 55 ], which observed no impacts of AFB 1 on the IBV titer of Ross 308 male broiler chickens at 75 and 750 ppb over the course of 5 weeks. On the other hand, there was a strong negative correlation (r 2 = 0.96) at day 42 between the IBV titer and AFB 1 concentrations (0, 250, 500, 750 ppb) in Ross broilers, revealing that this effect might relate to the potential of AFB 1 to inhibit RNA polymerase, and consequently, depression in protein synthesis and specific immunoglobulins [ 56 ]. Moreover, Jahanian et al (2019) [ 8 ] observed a reduction for IBV titers (20 days of age) in birds fed aflatoxins (500, 2000 ppb) from 7 to 28 days of age.…”

“…Moreover, Jahanian et al (2019) [ 8 ] observed a reduction for IBV titers (20 days of age) in birds fed aflatoxins (500, 2000 ppb) from 7 to 28 days of age. Aflatoxin B 1 increases the activity of lysosomal enzymes of skeletal muscle and liver; this effect enhances antibody degradation; aflatoxin inhibits the phagocytic cells of the reticuloendothelial systems, which are involved in the processing of antigens, as well as cells of the bursa of fabricius involved in the initiation of the humoral response [ 56 ]. It has been expressed that lymphoid organs are vulnerable to mycotoxins because of lysosomes and hydrolytic enzymes activities.…”