Perforant pathway activation of hippocampal CA1 stratum pyramidale neurons: Electrophysiological evidence for a direct pathway

Doller, Herbert J.; Weight, Forrest F.

doi:10.1016/0006-8993(82)90553-4

Cited by 76 publications

(37 citation statements)

References 12 publications

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“…In the case of posttraining CaMKII and ERK2 activation in CA1 and ERK2 activation in BLA, the results fit with findings that specific inhibitors of these two kinases are amnesic when given into CA1, but only inhibitors of ERK1/2 are amnesic when given into BLA in the IA task (1,2,28,45). Also, the TH data (posttraining increase in BLA, no change in CA1) fit with the finding that AMPT is amnesic when given into BLA but not CA1.…”

Section: Discussionsupporting

confidence: 77%

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Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala

Cammarota

Bevilaqua

Rossato

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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There is abundant literature on the role of the basolateral amygdala (BLA) and the CA1 region of the hippocampus in memory formation of inhibitory avoidance (IA) and other behaviorally arousing tasks. Here, we investigate molecular correlates of IA consolidation in the two structures and their relation to NMDA receptors (NMDArs) and ␤-adrenergic receptors (␤-ADrs). The separate posttraining administration of antagonists of NMDAr and ␤-ADr to BLA and CA1 is amnesic. IA training is followed by an increase of the phosphorylation of calcium and calmodulin-dependent protein kinase II (CaMKII) and ERK2 in CA1 but only an increase of the phosphorylation of ERK2 in BLA. The changes are blocked by NMDAr antagonists but not ␤-ADr antagonists in CA1, and they are blocked by ␤-ADr but not NMDAr antagonists in BLA. In addition, the changes are accompanied by increased phosphorylation of tyrosine hydroxylase in BLA but not in CA1, suggesting that ␤-AD modulation results from local catecholamine synthesis in the former but not in the latter structure. NMDAr blockers in CA1 do not alter the learning-induced neurochemical changes in BLA, and ␤-ADr blockade in BLA does not hinder those in CA1. When put together with other data from the literature, the present findings suggest that CA1 and BLA play a role in consolidation, but they operate to an extent in parallel, suggesting that each is probably involved with different aspects of the task studied.consolidation ͉ inhibitory avoidance ͉ learning

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Section: Discussionsupporting

confidence: 77%

“…It is generally agreed that it does so through influences mediated by entorhinal and perirhinal neurons (25) and, in many cases (26,27), but not all (28)(29)(30), probably the dentate gyrus (26)(27)(28)(29)(30)(31)(32).…”

mentioning

confidence: 99%

Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala

Cammarota

Bevilaqua

Rossato

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Together with the EC-CA1 pathway, this cortico-hippocampal input is often called the temporoammonic path. The two separate branches of the perforant path projection to the HF have also been corroborated by electrophysiological studies [51][52][53][54][55] .…”

Section: Entorhinal Cortex As a Main Station Relaying Pain Sig-mentioning

confidence: 62%

Roles of the hippocampal formation in pain information processing

2009

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Abstract:Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchicallyinterconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation (HF) in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.

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“…The "direct" pathway from the entorhinal cortex is called the perforant path (PP) and terminates on the most distant CA1 dendrites in the stratum lacunosum moleculare. This pathway is a major source of specific sensory information for the hippocampus (Vinogradova, 1984;McNaughton et al, 1989) and can evoke postsynaptic firing (Bragin and Otmakhov, 1979;Doller and Weight, 1982;Yeckel and Berger, 1990). A second input to CA1 is through the Schaffer collateral (SC) axons of CA3 cells that terminate more proximally in the stratum radiatum.…”

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confidence: 99%

Pathway-Specific Properties of AMPA and NMDA-Mediated Transmission in CA1 Hippocampal Pyramidal Cells

2002

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CA1 pyramidal cells receive glutamatergic input from the entorhinal cortex through the perforant path (PP) and from CA3 through Schaffer collaterals (SC). The PP input terminates in the stratum lacunosum moleculare ϳ300 m from the cell body, whereas SC synapses have a more proximal location in the stratum radiatum. We compared the properties of AMPA-and NMDA-mediated transmission at these two inputs. The AMPAmediated components have linear voltage dependence in both inputs. The reversal potential in the PP is only slightly more positive than in the SC, indicating that distal membrane voltage could be effectively set. The NMDA-mediated responses in the two pathways, however, are very different. The PP exhibits inward rectification, as evidenced by very low outward currents. The rectification persists in the absence of extracellular Mg 2ϩ . It cannot be attributed to clamping problems, because large outward AMPA currents can be observed even when conditions are modified to have the AMPA currents kinetically match the NMDA currents. Thus, it appears that the PP NMDA channels have novel properties. A second difference between the PP and SC pathways is that the PP has a larger NMDA/AMPA charge ratio. This difference could be observed under many conditions, including block of all voltage-dependent conductances and elimination of the negative resistance of NMDA channels by removing extracellular Mg 2ϩ . The difference in ratio thus cannot be attributed to regenerative currents. The higher NMDA component of the distal PP synapses could help to make these synapses more powerful under depolarizing conditions.Key words: AMPA; CA1; D890; inward rectification; NMDA; perforant path; regenerative process; Schaffer collaterals; voltage dependence; ZD7288 Dendrites create sites for the convergence of large numbers (Ͼ10 5 ) of synaptic inputs. The difference in distances of synapses from the cell body means that inputs with different locations will undergo different electrotonic attenuation as current flows toward the soma. There is increasing evidence that synaptic responses can be affected by voltage-dependent conductance (Stuart and

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Perforant pathway activation of hippocampal CA1 stratum pyramidale neurons: Electrophysiological evidence for a direct pathway

Cited by 76 publications

References 12 publications

Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala

Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala

Roles of the hippocampal formation in pain information processing

Pathway-Specific Properties of AMPA and NMDA-Mediated Transmission in CA1 Hippocampal Pyramidal Cells

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