Perfluorooctanoic Acid (PFOA) Exposure in Early Life Increases Risk of Childhood Adiposity: A Meta-Analysis of Prospective Cohort Studies

Li, Pingping; Yang, Fang; Wang, Yongbo; Zhu, Yuan

doi:10.3390/ijerph15102070

Cited by 36 publications

(26 citation statements)

References 43 publications

(103 reference statements)

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“…In most studies, higher PFOA concentration exposure was associated with mean birth weight loss, but only some results were statistically signi cant (Bach, Bech et al 2015). In another meta-analysis, the results showed that early exposure to PFOA was associated with an increased risk of childhood obesity (Liu, Yang et al 2018). By comparison, researchers found that no large number of studies had shown that PFOA was associated with LBW in offspring.…”

Section: Discussionmentioning

confidence: 99%

The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis

Cao

et al. 2021

Environ Sci Pollut Res

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Some studies have shown that maternal per uoroalkylated substances (PFAS) exposure may be associated with low birth weight (LBW) of offspring. We conducted a meta-analysis to assess the association between maternal PFASs exposure and LBW in offspring. The researchers searched PubMed, Science Direct, Scopus, Google Scholar, Web of Science, and Embase to nd all the articles before October 2020. The Newcastle-Ottawa Scale was used to evaluate the quality of the studies. Finally, six articles were included for meta-analysis. Our meta-analysis showed were no signi cant correlation between maternal per uorooctanoic acid (PFOA) exposure and LBW of offspring: odds ratio (OR) = 0.90, 95% con dence interval (95% CI) = 0.80-1.01, with low heterogeneity (I 2 = 18.4%, P = 0.289); there was a signi cant positive correlation between maternal per uorooctane sulfonate (PFOS) exposure and LBW of offspring (OR = 1.32, 95% CI = 1.09-1.55) with no heterogeneity (I 2 = 0.00%, P = 0.570). The grouping analysis of PFOS showed was a signi cant positive correlation between maternal PFOS exposure and LBW of offspring in America (OR = 1.44, 95% CI = 1.15-1.72). This study provided a systematic review and meta-analysis evidence for the relationship between maternal PFASs exposure and LBW of offspring through a small number of studies. Researchers should conduct further studies between different regions.

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Section: Discussionmentioning

confidence: 99%

The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis

Cao

et al. 2021

Environ Sci Pollut Res

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“…There are more than 9000 PFAS, 50 but only a handful have been studied for human exposure and health effects. Adverse health effects associated with PFAS include: decreased birthweight and length in newborns 51–53 and obesity in children 54 . Additional concerns include: neurodevelopment, 55 allergic rhinitis in children 56 and thyroid function 57 .…”

Section: Hazards Of Plastic Usementioning

confidence: 99%

Buy‐now‐pay‐later: Hazards to human and planetary health from plastics production, use and waste

Symeonides

Brunner

Mulders

et al. 2021

J Paediatrics Child Health

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More than 8 billion tonnes of plastic were produced between 1950 and 2015, that is 1 tonne for every man, woman and child on our planet. Global plastic production has been growing exponentially with an annual growth rate of 8.4% since 1950, equating to approximately 380 million tonnes per annum. A further 50 kg of plastic is now being produced for each person every year with production continuing to accelerate. Here, we discuss the human and planetary health hazards of all that plastic. We consider each step in the journey of these complex and pervasive industrial materials: from their synthesis predominantly from fossil fuel feedstocks, through an often‐brief consumer use as plastic products, and onto waste streams as fuel, permanent landfill or as unmanaged waste in our environment, food, air and bodies.

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“…At the same time, sexual dimorphism was sometimes linked with it [75][76][77][78][79]. A metapopulation analysis, including ten cohorts, suggests a 25% and 0.1 unit increase in weight and BMI, respectively, per ng/ml of PFOA concentration in maternal blood [80].…”

Section: Epidemiological Evidence Of Obesogens 61 Human Cohort Studiesmentioning

confidence: 99%

Environmental Obesogens and Human Health

Mahapatra¹,

Gupta²,

Suman³

et al. 2021

Hot Topics in Endocrinology and Metabolism

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Obesity is an alarming public health concern that contributes to a substantially increased risk of multiple chronic disorders, including diabetes. As per WHO data, in 2016, almost 39% adult population of the world is overweight, 13% of them were obese. There is prominent evidence on the involvement of environmental endocrine-disrupting chemicals, termed obesogens, in the prevalence of this growing worldwide pandemic, obesity. The exaggerated effect of obesogens on endocrine disruption, lipid metabolism and homeostasis, adipocyte functioning, impaired thermogenesis, inflammation, epigenetics, and overall human health will be covered in this chapter. This chapter will discuss the environmental obesogen hypothesis, the epidemiological and experimental evidence of obesogens, its chemical characteristics, and possible mechanism of actions. It will also focus on some recent indications of obesogens and their correlation in COVID-19 disease pathogenesis. This chapter will try to conclude with strategies for identifying the underlying mechanisms of obesogens within model systems and the human body, including future directions.

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Perfluorooctanoic Acid (PFOA) Exposure in Early Life Increases Risk of Childhood Adiposity: A Meta-Analysis of Prospective Cohort Studies

Cited by 36 publications

References 43 publications

The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis

The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis

Buy‐now‐pay‐later: Hazards to human and planetary health from plastics production, use and waste

Environmental Obesogens and Human Health

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