Perfluorocarbons as oxygen-transport fluids

Lowe, K. C.

doi:10.1016/0300-9629(87)90001-6

Cited by 99 publications

(40 citation statements)

References 95 publications

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“…The effect of PFC as a blood substitute on an in vivo system has been extensively studied and reviewed (21,22). No significant disturbance in living systems has been reported and some PFCs are approved for use in human studies.…”

Section: Perfluorocarbonmentioning

confidence: 99%

Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI

Lee

Duong

Yang

et al. 2001

Magnetic Resonance in Med

255

225

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Measurement of cerebral arterial and venous blood volumes during increased cerebral blood flow can provide important information regarding hemodynamic regulation under normal, pathological, and neuronally active conditions. In particular, the change in venous blood volume induced by neural activity is one critical component of the blood oxygenation level-dependent (BOLD) signal because BOLD contrast is dependent only on venous blood, not arterial blood. Thus, relative venous and arterial blood volume (rCBV) and cerebral blood flow (rCBF) in ␣-chlorolase-anesthetized rats under hypercapnia were measured by novel diffusion-weighted 19

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Section: Perfluorocarbonmentioning

confidence: 99%

Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI

Lee

Duong

Yang

et al. 2001

Magnetic Resonance in Med

255

225

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“…While the arguments over choice of surfactant(s) contin ue, it is somewhat paradoxical that the neutrophil-inhib iting effects attributable to Pluronic [7,8,66,69] may be advantageous when PFC emulsions are used, for example, in the ischaemic myocardium to protect against neutrophil- induced reperfusion injury [9]. Indeed, Bajaj et al [71] have shown that the effects of F-DA on myocardial salvage in dogs appeared to involve suppression of neutrophil func tion (see below).…”

Section: Effects On Tissue Biochemistrymentioning

confidence: 99%

“…The in terested reader is therefore referred to recent specialist reviews in this area [1,2,[5][6][7][8][9][10][11]49],…”

Section: Biocompatiblity Testingmentioning

confidence: 99%

“…Perfluoropolymers such as Teflon (polytetrafluoroethylene) are widely used, pri marily for their mechanical properties, durability and in ertness. This includes applications as orthopaedic implants -such as artificial hips, knees and jaws -together with replacement vascular structures, including arteries and car Gas Solubility PFC liquids have a very high solubility for gases and it was this property that led to their assessment as vehicles for respiratory gas transport [1,2,[5][6][7][8][9][10][11] and for regulating gas supply to cell cultures [12,13]. 02 solubility in PFCs is typically 40-50 vol%, whereas C02 solubility can be 3-4 times greater.…”

Section: Generalmentioning

confidence: 99%

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Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

Lowe¹

1991

Vox Sanguinis

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Recent advances in the development and assessment of synthetic oxygen transport fluids based on perfluorochemicals (PFCs) are reviewed. The basic properties of PFCs are outlined, together with the selection criteria for biomedical applications. PFCs must be emulsified for intravascular use and attention is focussed on the formulation and biocompatibility testing of both first- and second-generation emulsions and their components in man and other species. The multidisciplinary applications for PFCs in medicine and basic biomedical research are described, including the clinical use of Fluosol-DA 20% as an oxygen-carrying perfusate in percutaneous transluminal coronary angioplasty.

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“…2) and PFC emulsions can function as excellent oxygen carriers, and have proven largely nontoxic in human trials as blood substitutes. 30 As designed, the PFC core disperses PTM radicals in aqueous phase, thus enabling their use in biological studies. In this study, we kept the design complexity to a minimum.…”

mentioning

confidence: 99%

Trityl radicals in perfluorocarbon emulsions as stable, sensitive, and biocompatible oximetry probes

Dhimitruka

Alzarie

Hemann

et al. 2016

Bioorganic & Medicinal Chemistry Letters

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EPR oximetry with the use of trityl radicals can enable sensitive O2 measurement in biological cells and tissues. However, in vitro cellular and in vivo biological applications are limited by rapid trityl probe degradation or biological clearance and the need to enhance probe O 2 sensitivity. We synthesized novel perfluorocarbon (PFC) emulsions, ~200 nm droplet size, containing esterified perchlorinated triphenyl methyl (PTM) radicals dispersed in physiological aqueous buffers. These formulations exhibit excellent EPR signal stability, over 20-fold greater than free PTM probes, with high oxygen sensitivity ~17 mG/mmHg enabling pO2 measurement in aqueous solutions or cell suspensions with sensitivity > 0.5 mmHg. Thus, PFC-PTM probes hold great promise to enable combined O2 delivery and sensing as needed to restore or enhance tissue oxygenation in disease.

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Perfluorocarbons as oxygen-transport fluids

Cited by 99 publications

References 95 publications

Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI

Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI

Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

Trityl radicals in perfluorocarbon emulsions as stable, sensitive, and biocompatible oximetry probes

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