Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI

Lee, Phil; Duong, Timothy Q.; Yang, Guang; Iadecola, Costantino; Kim, Seong Gi

doi:10.1002/mrm.1107

Cited by 254 publications

(275 citation statements)

References 36 publications

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“…Figure 3C shows a relatively larger proportion of 'arterial' CBV change in surface GM voxels compared to deeper GM voxels, while the 'venous' contribution to the total CBV change occurs predominantly in deeper tissue voxels. This is consistent with the fact that the contribution of larger veins at the surface is small compared to the overall CBV change, dominated by arterioles and capillaries (Hillman et al, 2007;Lee et al, 2001). The larger arterioles close to the cortical surface, on the other hand, can contribute to the CBV change, in addition to the smaller arterioles and capillaries.…”

Section: Discussionsupporting

confidence: 86%

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T

et al. 2014

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Section: Discussionsupporting

confidence: 86%

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T

et al. 2014

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“…This result is in accordance with the results obtained by Boas et al (2008). Moreover, the relatively insignificant contribution of venous dilation has been recently observed experimentally Kim et al, 2007;Lee et al, 2001;Vanzetta et al (2005)). As pointed out by Vanzetta et al (2005), these recent results are inconsistent with the important role ascribed to venous compliance in previous theoretical models of the BOLD signal -e.g., the "balloon model" (Buxton and Frank, 1997;Buxton et al, 1998) and windkessel models (Kong et al, 2004;Mandeville et al, 1999).…”

Section: Blood Flow Control and Passive Responsessupporting

confidence: 93%

“…However, as noted by Boas et al (2008) it is not clear whether dominant volume changes occur on the arteriole side Kim et al, 2007;Lee et al, 2001;Vanzetta et al, 2005) or venous side (Buxton et al, 1998;Kong et al, 2004;Mandeville et al, 1999). Our results indicate that the arteriolar blood volume change comprises more than 96%, i.e., the major portion of the blood volume change.…”

Section: Blood Flow Control and Passive Responsesmentioning

confidence: 49%

Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network. Part II: Flow variations induced by global or localized modifications of arteriolar diameters

Lorthois¹,

Cassot²,

Lauwers³

2011

NeuroImage

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. In a companion paper (Lorthois et al., Neuroimage, in press), we perform the first simulations of blood flow in an anatomically accurate large human intra-cortical vascular network (~10000 segments), using a 1D non-linear model taking into account the complex rheological properties of blood flow in microcirculation. This model predicts blood pressure, blood flow and hematocrit distributions, volumes of functional vascular territories, regional flow at voxel and network scales, etc. Using the same approach, we study flow reorganizations induced by global arteriolar vasodilations (an isometabolic global increase in cerebral blood flow). For small to moderate global vasodilations, the relationship between changes in volume and changes in flow is in close agreement with Grubb's law, providing a quantitative tool for studying the variations of its exponent with underlying vascular architecture. A significant correlation between blood flow and vascular structure at the voxel scale, practically unchanged with respect to baseline, is demonstrated. Furthermore, the effects of localized arteriolar vasodilations, representative of a local increase in metabolic demand, are analyzed. In particular, localized vasodilations induce flow changes, including vascular steal, in the neighboring arteriolar trunks at small distances (b 300 μm), while their influence in the neighboring veins is much larger (about 1 mm), which provides an estimate of the vascular point spread function. More generally, for the first time, the hemodynamic component of various functional neuroimaging techniques has been isolated from metabolic and neuronal components, and a direct relationship with several known characteristics of the BOLD signal has been demonstrated. IntroductionThere is increasing recognition that, by its structural implication in neuro-vascular coupling, underlying vascular architecture is a key player in hemodynamically based functional imaging techniques (including fMRI and PET) (Harrison et al., 2002;d'Esposito et al., 2003;Logothetis and Wandell, 2004;Lauwers et al., 2008;Weber et al., 2008). In particular, the spatial resolution and specificity of such techniques are bound to the density of blood capillary vasculature and blood flow regulating structures (Harel et al., 2006). This is especially important in the context of high field fMRI Harel et al., 2006), because, despite a dramatic increase in the theoretical spatial resolution obtained by using higher magnetic fields, associated with other hardware advancements, "the spatial extent of the hemodynamic response ultimately will impose a fundamental limitation on the spatial resolution of fMRI modalities" ).However, little is known about the fundamentals of the relationship between vascular structure and hemodynamic changes induced by brain activation. A growing body of evidence indicates that neurons, glia, and cerebral blood vessels, actin...

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“…In addition, there were remarkably similar and significant aBV GM -CBF relationships in all three conditions, as evidenced by power law analyses. The relatively high a-values of 0.55 to 0.69 are consistent with the few studies showing significant arterial blood volume responses that correlated with flow increases in rodents during hypercapnia (Lee et al, 2001) and sensory stimulation (Kim et al, 2007;Kim and Kim, 2010). These studies also show that most of the total CBV changes during hypercapnia and visual stimulation arise from the arterial component.…”

Section: Vascular Reactions During Functional Challengessupporting

confidence: 88%

Similarities and Differences in Arterial Responses to Hypercapnia and Visual Stimulation

Petersen

Zimine³

et al. 2010

J Cereb Blood Flow Metab

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Despite the different origins of cerebrovascular activity induced by neurogenic and nonneurogenic conditions, a standard assumption in functional studies is that the consequence on the vascular system will be mechanically similar. Using a recently developed arterial spin labeling method, we examined arterial blood volume, arterial-microvascular transit time, and cerebral blood flow (CBF) in the gray matter and in areas with large arterial vessels under hypercapnia, visual stimulation, and a combination of the two. Spatial heterogeneity in arterial reactivity was observed between conditions. During hypercapnia, large arterial volume changes contributed to CBF increase and further downstream, there were reductions in the gray matter transit time. These changes were not significant during visual stimulation, and during the combined condition they were moderated. These findings suggest distinct vascular mechanisms for large and small arterial segments that may be condition specific. However, the power relationships between gray matter arterial blood volume and CBF in hypercapnia (a = 0.69 ± 0.24) and visual stimulation (a = 0.68 ± 0.20) were similar. Assuming consistent capillary and venous volume responses across these conditions, these results offer support for a consistent total CBV-flow relationship typically assumed in blood oxygen-level dependent calibration techniques.

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Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI

Cited by 254 publications

References 36 publications

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T

Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network. Part II: Flow variations induced by global or localized modifications of arteriolar diameters

Similarities and Differences in Arterial Responses to Hypercapnia and Visual Stimulation

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