Perfluorocarbon loaded fluorinated covalent organic polymers with effective sonosensitization and tumor hypoxia relief enable synergistic sonodynamic-immunotherapy

Yang, Zhijuan; Tao, Danlei; Zhong, Wenzhao; Liu, Zhuang; Feng, Liangzhu; Chen, Meiwan

doi:10.1016/j.biomaterials.2021.121250

Cited by 69 publications

(56 citation statements)

References 37 publications

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“…[ 32 ] To further elucidate the mechanism underlying the synergistic effects, calreticulin (CRT) expression was evaluated on tumor sections to assess the ROS levels in tumors after various treatments. [ 33 ] ROS quickly exposes CRT via protein kinase RNA‐like endoplasmic reticulum kinase pathway. The strongest CRT signal intensity was observed in the PTT+SDT group, indicating that PTT‐induced thermal energy could overcome tumor hypoxia and enhance ultrasound‐activated ROS production.…”

Section: Resultsmentioning

confidence: 99%

Boron Imidazolate Framework‐Derived Porous Carbon Nanospheres for Dual‐Mode Bioimaging‐Guided Photothermal/Sonodynamic Synergistic Cancer Therapy

Ren

et al. 2022

Advanced Therapeutics

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Development of efficient nanotherapeutic agents to enhance anticancer therapeutic effects is challenging. In this study, photo/sono-dual-responsive boron imidazolate framework-derived single-component porous carbon nanospheres (PCNSs) are successfully developed for dual-mode bioimaging-guided photothermal/sonodynamic (PTT/SDT) synergistic therapy for triple-negative breast cancer. The PCNS not only exhibits satisfactory and excellent photothermal conversion ability under near-infrared laser irradiation but also demonstrates a promising capability as an efficient sonosensitizer to generate cytotoxic reactive oxygen species through inertial cavitation in response to low-intensity ultrasound stimulation. The outstanding photothermal effect enhances the blood flow in tumor tissues and thus improves the oxygen supply, helping to achieve a remarkable synergistic therapeutic effect in the PTT/SDT synergistic therapy without any tumor recurrence or systemic toxicity. Interestingly, the PCNS enables the precise visualization of solid tumors using contrast-enhanced ultrasound and photothermal dual-modal bioimaging techniques. Overall, this study provides valuable insights in developing all-in-one theranostic nanoplatforms for the clinical treatment of triple-negative breast cancer.

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Section: Resultsmentioning

confidence: 99%

Boron Imidazolate Framework‐Derived Porous Carbon Nanospheres for Dual‐Mode Bioimaging‐Guided Photothermal/Sonodynamic Synergistic Cancer Therapy

Ren

et al. 2022

Advanced Therapeutics

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“…A series of highly immunostimulatory signals initiate ICD called damage-associated molecular patterns (DAMPs). 51–53…”

Section: The Mechanism Of Sdtmentioning

confidence: 99%

Application of nanosonosensitizer materials in cancer sono-dynamic therapy

Hou

Xie

2022

RSC Adv.

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“…These interventions are often combined with oxygen or carbogen breathing in order to potentiate anti-cancer therapy (Krafft, 2020). It has been described that these approaches with an increase blood oxygen-carrying capacity may lead to an increase in response to radiation therapy (Teicher et al, 1991;Koch et al, 2002;Song et al, 2017;Zhou et al, 2018), photodynamic therapy (Fingar et al, 1988;Cheng et al, 2015;Tang et al, 2017;Song et al, 2018;Wang et al, 2018;Hu et al, 2019;Kv et al, 2020;Fang et al, 2021), sonodynamic therapy (Zeng et al, 2020;Guo et al, 2021), chemotherapy (Teicher et al, 1987;Teic her et al, 1990;Teicher, 1994;Song et al, 2019;Wu et al, 2020), and immunotherapy (Jiang et al, 2021;Yang et al, 2021).…”

Section: Decreasing Tumor Hypoxia By Improving the Oxygen Deliverymentioning

confidence: 99%

The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

Gallez

2022

Front. Pharmacol.

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Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness, metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor progression and resistance to radiotherapy, chemotherapy and immunotherapy, multiple approaches have emerged to target tumor hypoxia. It includes among others pharmacological interventions designed to alleviate tumor hypoxia at the time of radiation therapy, prodrugs that are selectively activated in hypoxic cells or inhibitors of molecular targets involved in hypoxic cell survival (i.e., hypoxia inducible factors HIFs, PI3K/AKT/mTOR pathway, unfolded protein response). While numerous strategies were successful in pre-clinical models, their translation in the clinical practice has been disappointing so far. This therapeutic failure often results from the absence of appropriate stratification of patients that could benefit from targeted interventions. Companion diagnostics may help at different levels of the research and development, and in matching a patient to a specific intervention targeting hypoxia. In this review, we discuss the relative merits of the existing hypoxia biomarkers, their current status and the challenges for their future validation as companion diagnostics adapted to the nature of the intervention.

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Perfluorocarbon loaded fluorinated covalent organic polymers with effective sonosensitization and tumor hypoxia relief enable synergistic sonodynamic-immunotherapy

Cited by 69 publications

References 37 publications

Boron Imidazolate Framework‐Derived Porous Carbon Nanospheres for Dual‐Mode Bioimaging‐Guided Photothermal/Sonodynamic Synergistic Cancer Therapy

Boron Imidazolate Framework‐Derived Porous Carbon Nanospheres for Dual‐Mode Bioimaging‐Guided Photothermal/Sonodynamic Synergistic Cancer Therapy

Application of nanosonosensitizer materials in cancer sono-dynamic therapy

The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

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