Perfluoroalkyl substances (PFAS) including structural PFOS isomers in plasma from elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)

Salihović, Samira; Kärrman, Anna; Lind, Lars; Lind, P. Monica; Lindström, Gunilla; Bavel, Bert van

doi:10.1016/j.envint.2015.05.003

Cited by 36 publications

(14 citation statements)

References 46 publications

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“…Independent of consumption group, women had lower PFOS and PFHxS concentrations than men, which is consistent with previous studies (Fromme et al, 2009). The effect of gender is probably a consequence of the enhanced elimination of PFASs via pregnancy, lactation, and menstruation Brantsaeter et al, 2013;Denys et al, 2014;Harada and Koizumi, 2009;Lorber et al, 2015;Salihovic et al, 2015;Wong et al, 2014). The lack of significant increasing trend across female consumption groups may be due to our small sample size combined with large individual variation.…”

supporting

confidence: 90%

Exposure to per- and polyfluoroalkyl substances through the consumption of fish from lakes affected by aqueous film-forming foam emissions — A combined epidemiological and exposure modeling approach. The SAMINOR 2 Clinical Study

Hansen

Vestergren

Herzke

et al. 2016

Environment International

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supporting

confidence: 90%

Exposure to per- and polyfluoroalkyl substances through the consumption of fish from lakes affected by aqueous film-forming foam emissions — A combined epidemiological and exposure modeling approach. The SAMINOR 2 Clinical Study

Hansen

Vestergren

Herzke

et al. 2016

Environment International

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“…Unlike the other PFAS we present, PFHxA is more bound to blood cells and whole blood would therefore be a more suitable blood matrix to determine PFHxA (Poothong et al 2017). Several other studies also failed to detect PFHxA in serum/plasma (Christensen et al 2016;Eriksson et al 2017;Salihovic et al 2015). Russell et al (2013) reported an apparent elimination half-life of PFHxA in whole blood from seven ski wax technicians as 32 d with a range of 14-49 d. Due to the fact that PFHxA was measured in serum in the present study, which did not adequately reflect the real body burden level, our estimation of the half-life is, therefore, unreliable.…”

Section: Environmental Health Perspectivesmentioning

confidence: 64%

Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam

Fletcher

Pineda

et al. 2020

Environ Health Perspect

205

136

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BACKGROUND: Firefighting foam-contaminated ground water, which contains high levels of perfluoroalkyl substances (PFAS), is frequently found around airports. In 2018 it was detected that employees at a municipal airport in northern Sweden had been exposed to high levels of short-chain PFAS along with legacy PFAS (i.e., PFOA, PFHxS, and PFOS) through drinking water. OBJECTIVES: In this study, we aimed to describe the PFAS profile in drinking water and biological samples (paired serum and urine) and to estimate serum half-lives of the short-chain PFAS together with legacy PFAS. METHODS: Within 2 weeks after provision of clean water, blood sampling was performed in all 26 airport employees. Seventeen of them were then followed up monthly for 5 months. PFHxA, PFHpA, PFBS, PFPeS, and PFHpS together with legacy PFAS in water and biological samples were quantified using LC/MS/MS. Half-lives were estimated by assuming one compartment, first-order elimination kinetics. RESULTS: The proportions of PFHxA, PFHpA, and PFBS were higher in drinking water than in serum. The opposite was found for PFHxS and PFOS. The legacy PFAS accounted for about 50% of total PFAS in drinking water and 90% in serum. Urinary PFAS levels were very low compared with serum. PFBS showed the shortest half-life {average 44 d [95% confidence interval (CI): 37, 55 d]}, followed by PFHpA [62 d (95% CI: 51, 80 d)]. PFPeS and PFHpS showed average half-lives as 0.63 and 1.46 y, respectively. Branched PFOS isomers had average half-lives ranging from 1.05 to 1.26 y for different isomers. PFOA, PFHxS, and linear PFOS isomers showed average half-lives of 1.77, 2.87, and 2.93 y, respectively. DISCUSSION: A general pattern of increasing half-lives with increasing chain length was observed. Branched PFOS isomers had shorter half-lives than linear PFOS isomers.

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“…Biomonitoring data provides a critical tool for evaluating the effectiveness of the voluntary and regulatory initiatives, and most studies report decreasing PFAS concentrations in human serum after the year 2000, with significant declines of PFOS and PFOA (Reviewed in Land et al 2018 ). However, trends for the longer chained PFASs like perfluoronanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) have been inconsistent across populations (Calafat et al 2007 ; Glynn et al 2012 ; Jain 2018 ; Kato et al 2011 ; Liu et al 2015 ; Olsen et al 2017 ; Salihovic et al 2015 ; Schroter-Kermani et al 2012 ). Furthermore, in cross-sectional studies assessing human exposure to PFASs, concentrations have frequently been reported to be positively associated with age and to birth cohorts (Haug et al 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Time trends of perfluoroalkyl substances in blood in 30-year old Norwegian men and women in the period 1986–2007

Berg

Sandanger

Hanssen

et al. 2021

Environ Sci Pollut Res

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Biomonitoring studies are helpful tools and can increase our knowledge on time trends in human blood concentrations of PFASs: how they relate to emission trends and the potential prenatal exposure for future generations. In this study, serum was sampled in cross-sections of men and women who were 30 years old in each of the years 1986, 1994, 2001, and 2007 in Northern Norway and analyzed for 23 PFASs. Differences in serum concentrations across sampling years were investigated graphically and with significance testing and compared with those observed in our previous longitudinal study using repeated individual measurements in older men in the same years. The results demonstrate overall increasing blood burdens of PFASs in men and women in reproductively active ages during 1986–2001 and decreases until 2007. However, longer chained PFASs were still increasing in 2007 indicating divergent time trends between the different PFASs, underlining the importance of continued biomonitoring. Comparisons between 30-year-old men and older men within the same population demonstrated variation in time trends in the exact same years, underlining that biomonitoring studies must regard historic exposures and birth cohort effects.

show abstract

Perfluoroalkyl substances (PFAS) including structural PFOS isomers in plasma from elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)

Cited by 36 publications

References 46 publications

Exposure to per- and polyfluoroalkyl substances through the consumption of fish from lakes affected by aqueous film-forming foam emissions — A combined epidemiological and exposure modeling approach. The SAMINOR 2 Clinical Study

Exposure to per- and polyfluoroalkyl substances through the consumption of fish from lakes affected by aqueous film-forming foam emissions — A combined epidemiological and exposure modeling approach. The SAMINOR 2 Clinical Study

Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam

Time trends of perfluoroalkyl substances in blood in 30-year old Norwegian men and women in the period 1986–2007

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