Perfil epidemiológico das ceratomicoses atendidas no HC-UNICAMP

Müller, Guilherme Gubert; Kara‐José, Newton; Castro, Rosane Silvestre de

doi:10.1590/s0004-27492012000400005

Cited by 8 publications

(7 citation statements)

References 14 publications

(17 reference statements)

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“…The incidence of such type was notified to be between 17% and 36% [1]. Three different classes of antifungal agents; echinocandins, azoles, and polyenes (natamycin, amphotericin B, and nystatin) were used for the treatment of fungal keratitis [2][3][4]. Natamycin (NAT) is the first antifungal agent for topical ophthalmic administration, approved by the Food and Drug Administration of the United States [5].…”

Section: Introductionmentioning

confidence: 99%

Ocular Delivery of Natamycin Solid Lipid Nanoparticle Loaded Mucoadhesive Gel: Formulation, Characterization and in Vivo Study

et al. 2020

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Objective: This study aimed to develop a novel topical ocular system of natamycin (NAT) by formulating and evaluating of NAT-solid lipid nanoparticle (SLN) loaded on mucoadhesive gels to improve its therapeutic activity and reduce the frequency of dosage to assist patient compliance. Methods: SLNs were prepared using lipids and Tween 80 or Pluronic F127 as stabilizers via modified high shear homogenization and ultrasound techniques. The prepared SLNs were characterized for particle size (PS), zeta potential (ZP), polydispersity index (PI), and entrapment efficiency percentage (EE %). The morphological examination for chosen SLNs was done using a transmission electron microscope (TEM). Carbapol 940 and Hydroxypropyl methylcellulose (HPMC) was incorporated with selected NAT-SLNs to form mucoadhesive gels. The prepared NAT-SLN gels were evaluated for drug content, mucoadhesion force, release study, and in vitro microbiological activity. In vivo study for the chosen formulae was done to evaluate its efficacy against keratitis in rabbits. Results: NAT-SLNs exhibited high EE % up to 99.167% and PS ranging from 128.35 to 1719.5 nm, with negatively charged ZP that confirmed the stability of SLNs. The NAT-SLN gels provided the high mucoadhesive force with a controlled release manner compared with the marketed-product MP. The in vivo experimental studies and histopathological examination showed the superiority of G2 (NAT-SLN (5% Pluronic F127 and 1:1 mixed lipid) 4% HPMC) over MP against Candida keratitis. Conclusion: According to the obtained results, G2 provided an effective pharmaceutical system against fungal keratitis in a controlled release manner compared with MP for reducing dosage frequency.

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Section: Introductionmentioning

confidence: 99%

Ocular Delivery of Natamycin Solid Lipid Nanoparticle Loaded Mucoadhesive Gel: Formulation, Characterization and in Vivo Study

et al. 2020

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“…was the most frequently isolated fungus, according to other authors. 3 , 10 Among the 64 cases of keratitis investigated herein, two patients were observed with dematiaceous fungi isolates: Cladophialophora sp. and Madurella sp.…”

Section: Discussionmentioning

confidence: 97%

“…Although sex, in this series, was not related to keratitis occurrence, epidemiological studies in southeastern Brazil showed that the highest number of keratitis cases occurred in male patients. 3 , 10 This difference in the incidence of keratitis between sexes, would be related to socioeconomic aspects.…”

Section: Discussionmentioning

confidence: 99%

“…The results obtained in this study corroborate the findings of other authors, who described a high frequency (49.3% and 64.9%) of keratitis among those who engage in farm work and other outdoor activities, respectively, as they are more likely to experience ocular trauma. 3 , 4 , 10 The chance of keratitis occurrence was 45 times higher in people whose labor activity was linked to farming ( Table 2 ). The use of safety glasses and prompt medical attention in cases of ocular trauma are measures that can reduce the incidence of keratitis among this group of workers.…”

Section: Discussionmentioning

confidence: 99%

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Non-viral microbial keratitis in adults: clinical and laboratory aspects

Cury

Chang

Pontes

2018

Brazilian Journal of Microbiology

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This study compares patients with and without non-viral microbial keratitis in relation to sociodemographic variables, clinical aspects, and involved causative agent. Clinical aspects, etiology and therapeutic procedures were assessed in patients with and without keratitis that were diagnosed in an Eye Care Center in Campo Grande, MS, Brazil. Patients were divided into two groups: (a) cases: 64 patients with non-viral microbial keratitis diagnosed at biomicroscopy; and (b) controls: 47 patients with other eye disorders that were not keratitis. Labor activity related to agriculture, cattle raising, and contact lens use were all linked to keratitis occurrence (p<0.005). In patients with keratitis, the most common symptoms were pain and photophobia, and the most frequently used medicines were fourth-generation fluoroquinolones (34.4%), amphotericin B (31.3%), and natamycin (28.1%). Microbial keratitis evolved to corneal perforation in 15.6% of cases; transplant was indicated in 10.9% of cases. Regarding the etiology of this condition, 23 (42.2%) keratitis cases were caused by bacteria (Pseudomonas aeruginosa, 12.5%), 17 (39.1%) by fungi (Fusarium spp., 14.1% and Aspergillus spp., 4.7%), and 4 (6.3%) by Acanthamoeba. Patients with keratitis present with a poorer prognosis. Rapid identification of the etiologic agent is indispensable and depends on appropriate ophthalmological collection and microbiological techniques.

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“…[41][42][43][44][45][46][47][48] Fungal keratitis is an important cause of ocular morbidity, especially in the tropical regions of the world. 49 However, clinical features of fungal keratitis are usually suggestive but not always diagnostic. 50 There are many in-vivo and in-vitro options that can help ophthalmologists in diagnosing fungal keratitis.…”

Section: Infectious Keratitismentioning

confidence: 99%