Perfil epidemiológico da hanseníase em um município brasileiro, no período de 2000 a 2006

Miranzi, Sybelle de Souza Castro; Pereira, Lívia Helena de Morais; Nunes, Altacílio Aparecido

doi:10.1590/s0037-86822010000100014

Cited by 107 publications

(118 citation statements)

References 16 publications

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“…Regarding the ethnicity of patients, in our study, Caucasians were the predominant race, which differs from previous findings in the literature 32,35,36 where Mulatos were the most prevalent affected population. It should be noted that many patients who are from different regions of the state and who are users of the HUJM in Cuiaba are predominantly Caucasians.…”

Section: Discussioncontrasting

confidence: 99%

“…Of the entire patient cohort, the age groups 14-33 and 34-53 years each represented one-third of the total patient population. This suggests that leprosy affects large number of individuals in the economically productive population, which causes high economic impacts due to their having to abstaining from work, caused by the development of permanent and physically disabling lesions 31,32 . Importantly, as these patients are not able to work, they have the right to seek sickness benefits and even disability retirement 33 .…”

Section: Discussionmentioning

confidence: 99%

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Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy

Rodrigues

Ribeiro

Berber³

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. Methods: Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level. Results: The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Significant differences were identified, which included hypochromic lesions predominantly in the BT clinical form (24%); diffuse-type lesions predominantly in the tuberculoid (TT) clinical form (28%); ill-defined lesion border dominance in lepromatous leprosy (LL) clinical forms (30%); an irregular lesion limit predominantly in LL clinical forms (32%); and a predominant Th1 immune response in the BT clinical form (41.7%). Conclusions: The evaluation of the immunological profile in leprosy patients may contribute to the more detailed diagnosis and possibly better characterization of the prognosis for these individuals.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy

Rodrigues

Ribeiro

Berber³

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…12,13 Although not signifi cant (p = 0.051), the results of this study suggest a higher level of education may contribute to the prevention of disabilities, an association which can be verifi ed with an increase in the number of cases analysed. Those with more time in the educational system, in addition to possibly having easier access to the health care system, may pay more attention to changes to their body, which may lead them to seek help earlier.…”

Section: Discussionmentioning

confidence: 54%

“…21 Disabilities and limitations in activities grow worse and become more frequent with age, irrespective of leprosy. 12,13,18 Professionals need to be aware of this fact and plan health care for this population bearing in mind the probable future need for further care.…”

Section: Discussionmentioning

confidence: 99%

Deficiências após a alta medicamentosa da hanseníase: prevalência e distribuição espacial

et al. 2012

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OBJECTIVE:To estimate the frequency of people with leprosy-related physical disabilities after release from multidrug treatment and to analyze their spatial distribution. METHODS:Descriptive cross-sectional study with 232 leprosy patients treated between 1998 and 2006. Physical disabilities were assessed using the World Health Organization disability grading and the eye-hand-foot (EHF) sum score. The residential address of patients and rehabilitation centers were geocoded. It was estimated the overall frequency of physical disability and frequency by disability grade (grade 0, grade 1, and grade 2) according to the WHO disability grading taking into consideration clinical and sociodemographic variables in the descriptive analysis. Student's t-test, chi-square test (χ2), and Fisher's test were used as appropriate at a 5% signifi cance level. RESULTS:Of the patients studied, 51.6% were female, mean age 54 years old (SD 15.7), 30.5% had less than 2 years of formal education, 43.5% were employed, and 26.9% were retired. Borderline leprosy was the most prevalent form of leprosy (39.9%). A total of 32% of these patients had disabilities according to the WHO disability grading and the EHF score. Disabilities increased with age (p = 0.029), they were more common in patients with multibacillary leprosy (p = 0.005) and poor self-rated physical health (p < 0.001). Those who required prevention/rehabilitation care traveled on average 5.5 km to the rehabilitation center. People with physical disabilities lived scattered across the city but they were mostly concentrated in the most densely populated and socioeconomically deprived area. CONCLUSIONS:There is a high frequency of people with leprosy-related disabilities after release from multidrug therapy. Prevention and rehabilitation actions should target uneducated and older patients, those who had multibacillary forms of leprosy and poor self-rated physical health. The travel distance to rehabilitation centers calls for reorganization of local care networks.

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“…This finding is similar to that observed by Monteiro et al 12 , who also found a predominance of low educational attainment among their study population. Low educational attainment affects treatment adherence and can make it difficult to interpret instructions about disability prevention 13 .…”

Section: Discussionmentioning

confidence: 99%

Assessment of the sensory and physical limitations imposed by leprosy in a Brazilian Amazon Population

Aben-Athar

Lima

Ishak

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Leprosy often results in sensory and physical limitations. This study aimed to evaluate these limitations using a quantitative approach in leprosy patients in Belém (Pará, Brazil). Methods: This epidemiological, cross-sectional study measured the sensory impairment of smell and taste through the use of a questionnaire and evaluated activity limitations of daily life imposed by leprosy through the Screening of Activity Limitation and Safety Awareness (SALSA) Scale. Data were collected from 84 patients and associations between the degree of disability and clinical and epidemiological characteristics were assessed. Results: The majority of patients were men (64.3%), married (52.4%), age 31-40 years old (26.2%), had primary education (50%), and were independent laborers (36.9%). The multibacillary operational classification (81%), borderline clinical form (57.1%), and 0 degrees of physical disability (41.7%) were predominant. SALSA scores ranged from 17 to 59 points, and being without limitations was predominant (53.6%). The risk awareness score ranged from 0 to 8, with a score of 0 (no awareness of risk) being the most common (56%). Evaluation of smell and taste sensory sensitivities revealed that 70.2% did not experience these sensory changes. Patients with leprosy reactions were 7 times more likely to develop activity limitations, and those who had physical disabilities were approximately four times more likely to develop a clinical picture of activity limitations. Conclusions: Most patients showed no sensory changes, but patients with leprosy reactions were significantly more likely to develop activity limitations. Finally, further studies should be performed, assessing a higher number of patients to confirm the present results.

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Perfil epidemiológico da hanseníase em um município brasileiro, no período de 2000 a 2006

Cited by 107 publications

References 16 publications

Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy

Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy

Deficiências após a alta medicamentosa da hanseníase: prevalência e distribuição espacial

Assessment of the sensory and physical limitations imposed by leprosy in a Brazilian Amazon Population

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