Perfil de sensibilidade e fatores de risco associados à resistência do Mycobacterium tuberculosis, em centro de referência de doenças infecto-contagiosas de Minas Gerais

Souza, Márcia Beatriz de; Antunes, Carlos Maurício de Figueiredo; Garcia, Guilherme Freire

doi:10.1590/s1806-37132006000500010

Cited by 14 publications

(16 citation statements)

References 13 publications

(11 reference statements)

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“…Along with the increase in the drug-resistance, another reasonable explanation for these findings is the increased capacity to detect drug-resistant TB cases in the state 17 . The demographic characteristics of the cases in São Paulo State and for the reference center of HCRP were similar to those reported in other Brazilian studies regarding age and sex 11 , 12 , 14 . …”

Section: Discussionsupporting

confidence: 79%

A Decade Trend of Multidrug Resistant Tuberculosis in São Paulo State, Brazil

Bollela

Puga

Moya

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this retrospective study was to review all the notified cases of multidrug-resistant tuberculosis (MDR-TB) in São Paulo State (Brazil), as well as to describe and discuss the clinical, microbiological and radiologic aspects in a single reference center, within the same state, from 2000 to 2012. There were 1,097 notifications of MDR-TB in São Paulo State over this period, 70% affecting men aged on average 38 years (10-77). There was a significant fall in the MDR-TB mortality rate from 30% to 8% (2000-2003 versus 2009-2012). The same trend was observed in the cases studied at the reference center. The number of notified cases increased and death rate reduced from 37.5% (2000-2005) to 3.4% (2006-2012). Among the 48 drug-resistant TB cases, 17 non-tuberculous Mycobacteria were isolated in the sputum culture of nine patients, without any clinical significance. TB and fungus co-infection was diagnosed in 15% (7/48) of these cases: three with confirmed chronic pulmonary aspergillosis and four with positive serological markers for paracoccidioidomycosis. Overall, the reports show that MDR-TB diagnosis and cure rates have increased, while the mortality rate has decreased significantly in São Paulo State including in the studied reference center.

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Section: Discussionsupporting

confidence: 79%

A Decade Trend of Multidrug Resistant Tuberculosis in São Paulo State, Brazil

Bollela

Puga

Moya

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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“…There were only few studies of risk factors for primary MDR-TB, although many studies of risk factors for MDR-TB were found 3–12. In this study, we found that the independent risk factors for primary MDR-TB were different from primary DS-TB in the multivariate analysis, although some risk factors were similar in the univariate analysis.…”

Section: Discussionmentioning

confidence: 43%

“…Except less fruit consumption, other risk factors for primary MDR-TB in our study were involved in risk factors for MDR-TB in previous studies 3–11. It is easy to understand that those with poor education, low income, and small living space more likely developed primary MDR-TB cases, because infectious disease and poverty often go hand in hand.…”

Section: Discussionmentioning

confidence: 64%

“…Although MDR-TB is initially associated with irregular anti-TB treatment,3–10 the person-to-person transmission of MDR-TB gets more and more common. Many studies in the 1990s indicated that nosocomial transmission of MDR-TB happened, and health workers or HIV/acquired immune deficiency syndrome (AIDS) patients were the easily infected groups 16–19.…”

Section: Discussionmentioning

confidence: 99%

“…Previous treatments for TB as a risk factor associated with MDR-TB were found in some surveys conducted in Brazil, Burkina Faso, Georgia, Spain, and Turkey 3–7. Other risk factors were previous use of fluoroquinolone and an injectable agent (other than streptomycin) in India,8,9 an initial treatment regimen that did not follow national guidelines in India,9 and treatment with INH and RFP for more than 180 days in China 10.…”

Section: Introductionmentioning

confidence: 99%

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Comparing Risk Factors for Primary Multidrug-Resistant Tuberculosis and Primary Drug-Susceptible Tuberculosis in Jiangsu Province, China: A Matched-Pairs Case-Control Study

Li¹,

Lü²,

Zu³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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To find out the reason why some people get infected directly with multidrug-resistant tuberculosis (MDR-TB), whereas some get infected with drug-susceptible tuberculosis (DS-TB), a 1:1:1 matched-pairs case-control study was conducted to identify predictors associated with primary MDR-TB and primary DS-TB against the control in Jiangsu Province, China. All three groups were geographically matched (by neighborhood) and matched on sex and age (±5 years). In total, 110 participants were enrolled in each of three matched groups. Conditional logistic regression analysis showed that predictors independently associated with primary MDR-TB were illiteracy or primary school education, annual per capita income ≤ US$2,000, per capita living space < 40 m2, and interval ≥ 7 days of eating fruits; predictors with primary DS-TB were body mass index ≤ 20 and feeling higher life pressure. This indicates that there are different predictors impacting the transmission range of primary MDR-TB and primary DS-TB in the general population.

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Successes and failures in the control of infectious diseases in Brazil: social and environmental context, policies, interventions, and research needs

et al. 2011

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Despite pronounced reductions in the number of deaths due to infectious diseases over the past six decades, infectious diseases are still a public health problem in Brazil. In this report, we discuss the major successes and failures in the control of infectious diseases in Brazil, and identify research needs and policies to further improve control or interrupt transmission. Control of diseases such as cholera, Chagas disease, and those preventable by vaccination has been successful through efficient public policies and concerted efforts from different levels of government and civil society. For these diseases, policies dealt with key determinants (eg, the quality of water and basic sanitation, vector control), provided access to preventive resources (such as vaccines), and successfully integrated health policies with broader social policies. Diseases for which control has failed (such as dengue fever and visceral leishmaniasis) are vector-borne diseases with changing epidemiological profiles and major difficulties in treatment (in the case of dengue fever, no treatment is available). Diseases for which control has been partly successful have complex transmission patterns related to adverse environmental, social, economic, or unknown determinants; are sometimes transmitted by insect vectors that are difficult to control; and are mostly chronic diseases with long infectious periods that require lengthy periods of treatment.

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Perfil de sensibilidade e fatores de risco associados à resistência do Mycobacterium tuberculosis, em centro de referência de doenças infecto-contagiosas de Minas Gerais

Abstract: In the present study, previous treatment for tuberculosis was found to be an independent risk factor for multidrug-resistant tuberculosis.

Cited by 14 publications

References 13 publications

A Decade Trend of Multidrug Resistant Tuberculosis in São Paulo State, Brazil

A Decade Trend of Multidrug Resistant Tuberculosis in São Paulo State, Brazil

Comparing Risk Factors for Primary Multidrug-Resistant Tuberculosis and Primary Drug-Susceptible Tuberculosis in Jiangsu Province, China: A Matched-Pairs Case-Control Study

Successes and failures in the control of infectious diseases in Brazil: social and environmental context, policies, interventions, and research needs

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